Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states [0.03%]
转录组分析揭示骨骼肌再生相关的干细胞状态随小鼠寿命而改变
Lauren D Walter,Jessica L Orton,Ioannis Ntekas et al.
Lauren D Walter et al.
In aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We co...
Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson's disease risk [0.03%]
外显子组测序在亚洲人群中鉴定出影响帕金森病风险的低频和罕见编码变异
Elaine Gy Chew,Zhehao Liu,Zheng Li et al.
Elaine Gy Chew et al.
Parkinson's disease (PD) is an incurable, progressive and common movement disorder that is increasing in incidence globally because of population aging. We hypothesized that the landscape of rare, protein-altering variants could provide fur...
Dysregulation of endogenous retroviruses triggers aging and senescence [0.03%]
内源性逆转录病毒调控异常引发衰老和细胞衰老
Jill A Kreiling
Jill A Kreiling
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial [0.03%]
烟酰胺核糖对慢性阻塞性肺疾病气道炎症影响的随机、双盲、安慰剂对照试验
Kristoffer L Norheim,Michael Ben Ezra,Indra Heckenbach et al.
Kristoffer L Norheim et al.
Chronic obstructive pulmonary disease (COPD) is a progressive, incurable disease associated with smoking and advanced age, ranking as the third leading cause of death worldwide. DNA damage and loss of the central metabolite nicotinamide ade...
Randomized Controlled Trial
Nature aging. 2024 Dec;4(12):1772-1781. DOI:10.1038/s43587-024-00758-1 2024
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection [0.03%]
空间转录组学和蛋白质组学揭示COVID-19感染引起的全脑变化
Ting Zhang,Yunfeng Li,Liuliu Pan et al.
Ting Zhang et al.
Understanding the pathophysiology of neurological symptoms observed after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing outcomes and therapeutics. To date, small sample sizes and narrow mol...
Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging [0.03%]
ATF3通过激活与衰老相关内源性反转录病毒驱动干扰素信号在机体衰老中的作用
Jian Mao,Qian Zhang,Yang Zhuang et al.
Jian Mao et al.
Reactivation of endogenous retroviruses (ERVs) has been proposed to be involved in aging. However, the mechanism of reactivation and contribution to aging and age-associated diseases is largely unexplored. In this study, we identified a sub...
Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing [0.03%]
清除高表达p21的衰老细胞可加速创面愈合
Nathan S Gasek,Pengyi Yan,Junyu Zhu et al.
Nathan S Gasek et al.
While senescent cells have detrimental roles in several contexts, they are highly heterogeneous. p16 highly expressing senescent cells have been reported to exert beneficial functions in wound healing. Here we use Xenium spatial transcripto...
Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability [0.03%]
基于临床概率调整的血浆生物标志物在阿尔茨海默病诊断中的应用研究
Joseph Therriault,Shorena Janelidze,Andréa Lessa Benedet et al.
Joseph Therriault et al.
Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers pr...
Chronic social stress induces p16-mediated senescent cell accumulation in mice [0.03%]
慢性社会压力可诱发小鼠p16介导的衰老细胞蓄积
Carey E Lyons,Jean Pierre Pallais,Seth McGonigle et al.
Carey E Lyons et al.
Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology underlying this phenomenon remains unclear. Here we assessed the effect of chronic stress on cellular senescence-a hallmark of aging. Exposure to...