Hannah Walters
Hannah Walters
Transposable element 5mC methylation state of blood cells predicts age and disease [0.03%]
血液细胞的转座元件5mC甲基化状态可预测年龄和疾病
Francesco Morandini,Jinlong Y Lu,Cheyenne Rechsteiner et al.
Francesco Morandini et al.
Transposable elements (TEs) are DNA sequences that expand selfishly in the genome, possibly causing severe cellular damage. While normally silenced, TEs have been shown to activate during aging. DNA 5-methylcytosine (5mC) is one of the main...
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging [0.03%]
蛋白质或异亮氨酸限制对生命后期生理和分子衰老特征的影响
Chung-Yang Yeh,Lucas C S Chini,Jessica W Davidson et al.
Chung-Yang Yeh et al.
Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are unknown. Here we investigate the conseq...
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity [0.03%]
年龄相关CD8+tissue resident记忆T细胞减少导致抗肿瘤免疫功能下降
Siyu Pei,Xiuyu Deng,Ruirui Yang et al.
Siyu Pei et al.
Aging compromises antitumor immunity, but the underlying mechanisms remain elusive. Here, we report that aging impairs the generation of CD8+ tissue resident memory T (TRM) cells in nonlymphoid tissues in mice, thus compromising the antitum...
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer [0.03%]
健康乳腺组织的全面单细胞衰老图谱揭示了衰老和癌症共有的表观基因组和转录组特征
Brittany L Angarola,Siddhartha Sharma,Neerja Katiyar et al.
Brittany L Angarola et al.
Aging is the greatest risk factor for breast cancer; however, how age-related cellular and molecular events impact cancer initiation is unknown. In this study, we investigated how aging rewires transcriptomic and epigenomic programs of mous...
A mortality timer based on nucleolar size triggers nucleolar integrity loss and catastrophic genomic instability [0.03%]
基于核仁大小的死亡计时器触发核仁完整性丧失和灾难性基因组不稳定性的产生
J Ignacio Gutierrez,Jessica K Tyler
J Ignacio Gutierrez
Genome instability is a hallmark of aging, with the highly repetitive ribosomal DNA (rDNA) within the nucleolus being particularly prone to genome instability. Nucleolar enlargement accompanies aging in organisms ranging from yeast to mamma...
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses [0.03%]
单核多组学分析揭示卵巢衰老的分子和遗传机制
Chen Jin,Xizhe Wang,Jiping Yang et al.
Chen Jin et al.
The ovary is the first organ to age in the human body, affecting both fertility and overall health. However, the biological mechanisms underlying human ovarian aging remain poorly understood. Here we present a comprehensive single-nuclei mu...
Shirley Genah,Enrico Velardi
Shirley Genah