Holly N Thomas
Holly N Thomas
Healthy aging in individuals born after assisted reproductive technology is a research area for the future [0.03%]
辅助生殖技术供胚生育者的健康老龄化是未来研究领域之一
Anna Sophie Lebech Kjaer,Maria Linander Vestager,Rikke Beck Jensen et al.
Anna Sophie Lebech Kjaer et al.
IL-23R is a senescence-linked circulating and tissue biomarker of aging [0.03%]
IL-23R是一个与衰老相关的循环组织生物标志物
Chase M Carver,Sonia L Rodriguez,Elizabeth J Atkinson et al.
Chase M Carver et al.
Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells, ca...
Martine Elbejjani,Adina Zeki Al Hazzouri,Kaylie Moropoulos et al.
Martine Elbejjani et al.
Plasma proteomics identify biomarkers and undulating changes of brain aging [0.03%]
血浆蛋白质组学鉴定脑衰老的生物标志物和波动变化
Wei-Shi Liu,Jia You,Shi-Dong Chen et al.
Wei-Shi Liu et al.
Proteomics enables the characterization of brain aging biomarkers and discernment of changes during brain aging. We leveraged multimodal brain imaging data from 10,949 healthy adults to estimate brain age gap (BAG), an indicator of brain ag...
Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions [0.03%]
老龄大脑的微小RNA谱系及其对神经精神疾病的遗传贡献
Selina M Vattathil,Ekaterina S Gerasimov,Se Min Canon et al.
Selina M Vattathil et al.
MicroRNAs (miRNAs) play a crucial role in regulating gene expression and influence many biological processes. Despite their importance, understanding of how genetic variation affects miRNA expression in the brain and how this relates to bra...
Anna Kriebs
Anna Kriebs
George Andrew S Inglis
George Andrew S Inglis
Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend [0.03%]
基于AgeXtend平台的可解释人工智能在寻找抗衰老物质方面的作用
Sakshi Arora,Aayushi Mittal,Subhadeep Duari et al.
Sakshi Arora et al.
Aging involves metabolic changes that lead to reduced cellular fitness, yet the role of many metabolites in aging is unclear. Understanding the mechanisms of known geroprotective molecules reveals insights into metabolic networks regulating...
A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging [0.03%]
一种嵌合肽促进了损伤、纤维化、肿瘤发生和衰老中衰老细胞的免疫监视
Xinliang Ming,Ze Yang,Yuqiao Huang et al.
Xinliang Ming et al.
The accumulation of senescent cells can lead to tissue degeneration, chronic inflammatory disease and age-related tumorigenesis. Interventions such as senolytics are currently limited by off-target toxicity, which could be circumvented by i...