Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas [0.03%]
结构不平等与大脑体积和网络动态在美洲的衰老和痴呆中的关联
Agustina Legaz,Florencia Altschuler,Raul Gonzalez-Gomez et al.
Agustina Legaz et al.
Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is u...
John R Beard,Katja Hanewald,Yafei Si et al.
John R Beard et al.
To understand how the health of older adults today compares to that of previous generations, we estimated intrinsic capacity and subdomains of cognitive, locomotor, sensory, psychological and vitality capacities in participants of the Engli...
C P Ryan,D L Corcoran,N Banskota et al.
C P Ryan et al.
Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effec...
Perspectives on biomarkers of reproductive aging for fertility and beyond [0.03%]
生殖衰老生物标志物的展望：从生育到更广泛的健康问题
Si Wang,Jie Ren,Ying Jing et al.
Si Wang et al.
Reproductive aging, spanning an age-related functional decline in the female and male reproductive systems, compromises fertility and leads to a range of health complications. In this Perspective, we first introduce a comprehensive framewor...
Julia L Balough,Shweta S Dipali,Karen Velez et al.
Julia L Balough et al.
The female reproductive axis is one of the first organ systems to age, which has consequences for fertility and overall health. Here, we provide a comprehensive overview of the biological process of female reproductive aging across reproduc...
Emerging therapeutic strategies to mitigate female and male reproductive aging [0.03%]
缓解生殖衰老的新兴治疗策略
Yasmyn E Winstanley,Jennifer S Stables,Macarena B Gonzalez et al.
Yasmyn E Winstanley et al.
People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this con...
Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause [0.03%]
探讨雌激素缺乏和衰老对绝经期机体稳态的影响
Celine Camon,Michael Garratt,Stephanie M Correa
Celine Camon
Sex hormone signaling declines during aging, from early midlife through menopause, as a consequence of reduced circulating estrogens and decreased receptiveness to these hormones in target tissues. Estrogens preserve energy homeostasis and ...
Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring [0.03%]
生殖特征的遗传学及其与健康、长寿和后代的关系
Stefania Benonisdottir,Vincent J Straub,Augustine Kong et al.
Stefania Benonisdottir et al.
Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shift...
Healthy longevity requires bridging reproductive medicine, aging research and public engagement [0.03%]
生殖医学、衰老研究和公众参与相融合才能实现健康长寿
Zhongwei Huang;NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE)
Zhongwei Huang;NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE)