Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage [0.03%]
绝经引起的雌二醇和孕酮丢失增加小鼠软骨衰老标志物、基质分解和退行性变化
Gabrielle Gilmer,Hirotaka Iijima,Zachary R Hettinger et al.
Gabrielle Gilmer et al.
Female individuals who are post-menopausal present with higher incidence of knee osteoarthritis (KOA) than male counterparts; however, the mechanisms underlying this disparity are unknown. The most commonly used preclinical models lack huma...
Yahyah Aman
Yahyah Aman
GD3 ganglioside checkpoints in immune surveillance of senescent cells [0.03%]
gd3糖脂在衰老细胞免疫监视中的作用机制研究
Julia Majewska,Valery Krizhanovsky
Julia Majewska
George Andrew S Inglis
George Andrew S Inglis
Semaglutide alleviates knee osteoarthritis pain in persons with obesity [0.03%]
司美格鲁肽可缓解肥胖人群的膝骨关节炎疼痛
Yahyah Aman
Yahyah Aman
Publisher Correction: Cohort trends in intrinsic capacity in England and China [0.03%]
校正：英格兰和中国的固有功能资本趋势
John R Beard,Katja Hanewald,Yafei Si et al.
John R Beard et al.
Published Erratum
Nature aging. 2025 Jan 13. DOI:10.1038/s43587-025-00808-2 2025
Zane Koch,Adam Li,Daniel S Evans et al.
Zane Koch et al.
DNA methylation marks have recently been used to build models known as epigenetic clocks, which predict calendar age. As methylation of cytosine promotes C-to-T mutations, we hypothesized that the methylation changes observed with age shoul...
Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence [0.03%]
肠道微生物衍生的苯乙酰谷氨酰胺加速宿主细胞衰老
Hao Yang,Tongyao Wang,Chenglang Qian et al.
Hao Yang et al.
Gut microbiota plays a crucial role in the host health in the aging process. However, the mechanisms for how gut microbiota triggers cellular senescence and the consequent impact on human aging remain enigmatic. Here we show that phenylacet...
Byeong-Seong Kim,Inwoo Hwang,Hyo Rim Ko et al.
Byeong-Seong Kim et al.
The abnormal deposition of amyloid β (Aβ), produced by proteolytic cleavage events of amyloid precursor protein involving the protease γ-secretase and subsequent polymerization into amyloid plaques, plays a key role in the neuropathology...
Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration [0.03%]
通过调节mTOR依赖性星形胶质细胞状态转换来缓解神经退行性疾病
Liansheng Zhang,Zhengzheng Xu,Zhiheng Jia et al.
Liansheng Zhang et al.
Traditional approaches to studying astrocyte heterogeneity have mostly focused on analyzing static properties, failing to identify whether subtypes represent intermediate or final states of reactive astrocytes. Here we show that previously ...