Kaitlyn H Hajdarovic,Doudou Yu,Lexi-Amber Hassell et al.
Kaitlyn H Hajdarovic et al.
Alterations in metabolism, sleep patterns, body composition, and hormone status are all key features of aging. While the hypothalamus is a well-conserved brain region that controls these homeostatic and survival-related behaviors, little is...
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking [0.03%]
增强表观遗传钟可靠性的计算解决方案：临床试验和纵向跟踪的启示
Albert T Higgins-Chen,Kyra L Thrush,Yunzhang Wang et al.
Albert T Higgins-Chen et al.
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show technical noise produces deviations up to 9 years between replicates for six prominent epige...
Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila [0.03%]
Drosophila神经元诱导BNIP3介导的线粒体自噬延缓全身衰老
Edward T Schmid,Jung-Hoon Pyo,David W Walker
Edward T Schmid
The effects of aging on the brain are widespread and can have dramatic implications on the overall health of an organism. Mitochondrial dysfunction is a hallmark of brain aging, but, the interplay between mitochondrial quality control, neur...
Alexandre Trapp,Csaba Kerepesi,Vadim N Gladyshev
Alexandre Trapp
DNA methylation dynamics emerged as a promising biomarker of mammalian aging, with multivariate machine learning models ('epigenetic clocks') enabling measurement of biological age in bulk tissue samples. However, intrinsically sparse and b...
Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries [0.03%]
脑淀粉样血管病与胶质淋巴转运下降和颈部动脉延时溶质引流相关性研究
Xinan Chen,Xiaodan Liu,Sunil Koundal et al.
Xinan Chen et al.
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease [0.03%]
APOE等位基因对正常衰老和阿尔茨海默病中胶质细胞转录组的影响
Alberto Serrano-Pozo,Zhaozhi Li,Ayush Noori et al.
Alberto Serrano-Pozo et al.
The roles of APOEε4 and APOEε2-the strongest genetic risk and protective factors for Alzheimer's disease-in glial responses remain elusive. We tested the hypothesis that APOE alleles differentially impact glial responses by investigating ...
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease [0.03%]
支持布美他尼通过计算复用用于APOE4相关性阿尔茨海默病的实验和真实世界证据
Alice Taubes,Phil Nova,Kelly A Zalocusky et al.
Alice Taubes et al.
The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-rel...
Cassandra J McGill,Bérénice A Benayoun
Cassandra J McGill
While investigating sex-differences in T-cell aging, Mkhikian et al., identified a role for excessive IL-7 signaling and N-glycan branching in age-related mouse and human female T-cell dysfunction. These findings point to the increasingly-r...
Xu Zhang,Leena Habiballa,Zaira Aversa et al.
Xu Zhang et al.
Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are prone to senesce has not been methodically examined. Herei...
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity [0.03%]
单个人体心肌细胞中的体细胞性突变揭示了与年龄相关的DNA损伤和普遍的氧化基因毒性
Sangita Choudhury,August Yue Huang,Junho Kim et al.
Sangita Choudhury et al.
The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and cha...