Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging [0.03%]
单细胞测序鉴定出毛细胞SLC35F1缺乏是灵长类 Cochlear 衰老的标志
Guoqiang Sun,Xiaolong Fu,Yandong Zheng et al.
Guoqiang Sun et al.
Cochlear aging causes substantial hearing impairment in older adults, yet primate-specific mechanisms remain poorly characterized. Our comprehensive analysis combining single-cell and histopathological profiling in aging Macaca fascicularis...
David Furman,Johan Auwerx,Anne-Laure Bulteau et al.
David Furman et al.
Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration o...
Yahyah Aman
Yahyah Aman
Shuying Chen,Qian Chen,Xinru You et al.
Shuying Chen et al.
Aging is characterized by a gradual decline of cellular and physiological functions over time and an increased risk of different diseases. RNA therapeutics constitute an emerging approach to target the molecular mechanisms of aging and age-...
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease [0.03%]
慢性肾脏病早期血管衰老的复发性体细胞突变和早老素表达
Gwladys Revêchon,Anna Witasp,Nikenza Viceconte et al.
Gwladys Revêchon et al.
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well under...
Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice [0.03%]
在5xFAD小鼠中增强微胶质细胞中的血管紧张素转换酶(ACE)可预防阿尔茨海默病
Andrew R Gomez,Hyae Ran Byun,Shaogen Wu et al.
Andrew R Gomez et al.
Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influenc...
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors [0.03%]
基于血液的表观遗传学时钟可预测死亡率并关联临床、免疫和生活方式因素
Matías Fuentealba,Laure Rouch,Sophie Guyonnet et al.
Matías Fuentealba et al.
Age-related decline in intrinsic capacity (IC), defined as the sum of an individual's physical and mental capacities, is a cornerstone for promoting healthy aging by prioritizing maintenance of function over disease treatment. However, asse...
Xueqing Jia,Zuyun Liu
Xueqing Jia