Paulo Neves,Bo Hao,Santeri Aikonen et al.
Paulo Neves et al.
The Buchwald-Hartwig cross-coupling is a cornerstone of modern pharmaceutical synthesis, yet predictive modeling of its outcomes remains constrained by data quality and chemical space coverage. Electronic laboratory notebooks contain hetero...
Continual integration of single-cell multimodal data with MIRACLE [0.03%]
基于MIRACLE的单细胞多模态数据的端到端整合方法
Jiahao Zhou,Jing Wang,Shuofeng Hu et al.
Jiahao Zhou et al.
Single-cell sequencing has transformed our understanding of cellular heterogeneity, enabling the construction of multi-omics atlases through data integration. However, conventional atlas updates require full reintegration of all datasets, c...
Gina El Nesr
Gina El Nesr
SpatialFormer: universal spatial representation learning from subcellular molecular to multicellular landscapes [0.03%]
空间形式化表示学习：从亚细胞分子到多细胞景观的通用空间表征学习模型
Jun Wang,Yuanhua Huang,Ole Winther
Jun Wang
Understanding gene spatial expression and the organization of multicellular systems is vital for disease diagnosis and studying biological processes. However, existing models often struggle to integrate gene expression data with cellular sp...
Structure-alignment-driven cross-graph modeling for functional RNA design [0.03%]
基于结构对齐的跨图模型的功能RNA设计方法
Shengfan Wang,Jun Wang,Xiaojian Liu et al.
Shengfan Wang et al.
RNAs are critical for biological processes, and their functions are closely tied to their three-dimensional structures. The design of RNA sequences that fold into target three-dimensional structures is a complex challenge due to the dynamic...
Natnatee Dokmai
Natnatee Dokmai
Cross-task, explainable and real-time decoding of human emotion states by integrating gray and white matter intracranial neural activity [0.03%]
基于脑灰质和白质颅内神经活动的人类情绪解码
Yuxiao Yang,Wenjun Chen,Yuyang Chen et al.
Yuxiao Yang et al.
Decoding human emotion states from intracranial neural activity is key in developing affective brain-computer interfaces and new therapies for affective disorders. However, real-world application of decoding requires high performance that i...