Jie Yuan,Sohail S Hassan,Jiaojiao Wu et al.
Jie Yuan et al.
Extended reality (XR) refers to an umbrella of methods that allows users to be immersed in a three-dimensional (3D) or a 4D (spatial + temporal) virtual environment to different extents, including virtual reality (VR), augmented reality (AR...
B E Bouma,J F de Boer,D Huang et al.
B E Bouma et al.
Optical coherence tomography (OCT) is a non-contact method for imaging the topological and internal microstructure of samples in three dimensions. OCT can be configured as a conventional microscope, as an ophthalmic scanner, or using endosc...
Thomas R M Barends,Benjamin Stauch,Vadim Cherezov et al.
Thomas R M Barends et al.
With the advent of X-ray Free Electron Lasers (XFELs), new, high-throughput serial crystallography techniques for macromolecular structure determination have emerged. Serial femtosecond crystallography (SFX) and related methods provide poss...
Stefani N Thomas,Deborah French,Paul J Jannetto et al.
Stefani N Thomas et al.
Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass s...
Designing clinical trials for rare diseases: unique challenges and opportunities [0.03%]
罕见病临床试验的设计：独特的挑战与机遇
Chiara Pizzamiglio,Hilary J Vernon,Michael G Hanna et al.
Chiara Pizzamiglio et al.
Orphan drug development is a rapidly expanding field. Nevertheless, clinical trials for rare diseases can present inherent challenges. Optimal study design and partnerships between academia and industry are therefore required for the succes...
Mickaël Lelek,Melina T Gyparaki,Gerti Beliu et al.
Mickaël Lelek et al.
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging techniques that dramatically improve spatial resolution over standard, diffraction-limited microscopy techniques and can image biological structures at th...
Timothy M Wannier,Peter N Ciaccia,Andrew D Ellington et al.
Timothy M Wannier et al.
Recombination-mediated genetic engineering, also known as recombineering, is the genomic incorporation of homologous single-stranded or double-stranded DNA into bacterial genomes. Recombineering and its derivative methods have radically imp...
Bárbara B Mendes,João Conniot,Aviram Avital et al.
Bárbara B Mendes et al.
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented opportunity to overcome these drawbacks; owing to their tu...
Fabrizio Torricelli,Demetra Z Adrahtas,Zhenan Bao et al.
Fabrizio Torricelli et al.
Electrolyte-gated transistors (EGTs), capable of transducing biological and biochemical inputs into amplified electronic signals and stably operating in aqueous environments, have emerged as fundamental building blocks in bioelectronics. In...
Karen M Hampson,Raphaël Turcotte,Donald T Miller et al.
Karen M Hampson et al.
Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally proposed to correct for the blurring effect of atmospheric turbulence on images in ground-based telescopes and was instrumental in the work that re...