Riccardo Levato,Oksana Dudaryeva,Carlos Ezio Garciamendez-Mijares et al.
Riccardo Levato et al.
Light-based vat-polymerization bioprinting enables computer-aided patterning of 3D cell-laden structures in a point-by-point, layer-by-layer or volumetric manner, using vat (vats) filled with photoactivatable bioresin (bioresins). This coll...
Julienne L Carstens,Santhoshi N Krishnan,Arvind Rao et al.
Julienne L Carstens et al.
Much like solving a game of Clue, understanding physiological mysteries involves answering who, what, when, and where. Multi-omics approaches delve into cellular and molecular identities (the who and what), while longitudinal data collectio...
Tianqi Yang,Siyuan Wang
Tianqi Yang
Correct organization of higher-order genome folding is essential for the regulation of gene expression, DNA replication and other genomic functions. Technological advances in high-throughput sequencing-based methods have allowed for systema...
Shuying Chen,Xiangang Huang,Yonger Xue et al.
Shuying Chen et al.
mRNA vaccines have emerged as a revolutionary tool to generate rapid and precise immune responses against infectious diseases and cancers. Compared with conventional vaccines such as inactivated viruses, viral vectors, protein subunits or D...
Shaopeng Liu,Judith S Rodriguez,Viorel Munteanu et al.
Shaopeng Liu et al.
Metagenomics has revolutionized our understanding of microbial communities, offering unprecedented insights into their genetic and functional diversity across Earth's diverse ecosystems. Beyond their roles as environmental constituents, mic...
Hui Li,Kuangwen Hsieh,Pak Kin Wong et al.
Hui Li et al.
Bacterial infections and antimicrobial resistance are a major cause for morbidity and mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where physicians empirically treat suspected bacterial infections wi...
Brillouin microscopy [0.03%]
布里渊显微镜
Irina Kabakova,Jitao Zhang,Yuchen Xiang et al.
Irina Kabakova et al.
The field of Brillouin microscopy and imaging was established approximately 20 years ago, thanks to the development of non-scanning high-resolution optical spectrometers. Since then, the field has experienced rapid expansion, incorporating ...
Top-down proteomics [0.03%]
自上而下蛋白质组学
David S Roberts,Joseph A Loo,Yury O Tsybin et al.
David S Roberts et al.
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is essential to unravel the intricacies of biological system...
Sulfur fluoride exchange [0.03%]
硫氟交换反应
Joshua A Homer,Long Xu,Namitharan Kayambu et al.
Joshua A Homer et al.
Sulfur Fluoride Exchange (SuFEx) is a click reaction par excellence that has revolutionized multiple research fields. In this Primer, we delve into the essential elements of SuFEx operation, catalysis, and SuFExable connective hubs. We also...
Liesbeth Minnoye,Georgi K Marinov,Thomas Krausgruber et al.
Liesbeth Minnoye et al.
Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied characteristic of the eukaryotic genome. As active regulatory DNA elements are generally 'accessible', the genome-wide profiling of chromatin accessib...