Zixuan Zhao,Xinyi Chen,Anna M Dowbaj et al.
Zixuan Zhao et al.
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissect...
Mendelian randomization [0.03%]
孟德尔随机化研究
Eleanor Sanderson,M Maria Glymour,Michael V Holmes et al.
Eleanor Sanderson et al.
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and ...
Peptidomics [0.03%]
肽组学
Roland Hellinger,Arnar Sigurdsson,Wenxin Wu et al.
Roland Hellinger et al.
Peptides are biopolymers, typically consisting of 2-50 amino acids. They are biologically produced by the cellular ribosomal machinery or by non-ribosomal enzymes and, sometimes, other dedicated ligases. Peptides are arranged as linear chai...
Christoph Bock,Paul Datlinger,Florence Chardon et al.
Christoph Bock et al.
CRISPR screens are a powerful source of biological discovery, enabling the unbiased interrogation of gene function in a wide range of applications and species. In pooled CRISPR screens, various genetically encoded perturbations are introduc...
Rosana S Molina,Gordon Rix,Amanuella A Mengiste et al.
Rosana S Molina et al.
Jie Yuan,Sohail S Hassan,Jiaojiao Wu et al.
Jie Yuan et al.
Extended reality (XR) refers to an umbrella of methods that allows users to be immersed in a three-dimensional (3D) or a 4D (spatial + temporal) virtual environment to different extents, including virtual reality (VR), augmented reality (AR...
B E Bouma,J F de Boer,D Huang et al.
B E Bouma et al.
Optical coherence tomography (OCT) is a non-contact method for imaging the topological and internal microstructure of samples in three dimensions. OCT can be configured as a conventional microscope, as an ophthalmic scanner, or using endosc...
Thomas R M Barends,Benjamin Stauch,Vadim Cherezov et al.
Thomas R M Barends et al.
With the advent of X-ray Free Electron Lasers (XFELs), new, high-throughput serial crystallography techniques for macromolecular structure determination have emerged. Serial femtosecond crystallography (SFX) and related methods provide poss...
Stefani N Thomas,Deborah French,Paul J Jannetto et al.
Stefani N Thomas et al.
Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass s...
Designing clinical trials for rare diseases: unique challenges and opportunities [0.03%]
罕见病临床试验的设计：独特的挑战与机遇
Chiara Pizzamiglio,Hilary J Vernon,Michael G Hanna et al.
Chiara Pizzamiglio et al.
Orphan drug development is a rapidly expanding field. Nevertheless, clinical trials for rare diseases can present inherent challenges. Optimal study design and partnerships between academia and industry are therefore required for the succes...