Atom probe tomography [0.03%]
原子探针层析术
Baptiste Gault,Ann Chiaramonti,Oana Cojocaru-Mirédin et al.
Baptiste Gault et al.
Atom probe tomography (APT) provides three-dimensional compositional mapping with sub-nanometre resolution. The sensitivity of APT is in the range of parts per million for all elements, including light elements such as hydrogen, carbon or l...
Paul Rees,Huw D Summers,Andrew Filby et al.
Paul Rees et al.
Imaging flow cytometry combines the high throughput nature of flow cytometry with the advantages of single cell image acquisition associated with microscopy. The measurement of large numbers of features from the resulting images provides ri...
Colinda L G J Scheele,David Herrmann,Erika Yamashita et al.
Colinda L G J Scheele et al.
Tissues are heterogeneous with respect to cellular and non-cellular components and in the dynamic interactions between these elements. To study the behaviour and fate of individual cells in these complex tissues, intravital microscopy (IVM)...
Ulrich Blache,Eden M Ford,Byunghang Ha et al.
Ulrich Blache et al.
Cells' local mechanical environment can be as important in guiding cellular responses as many well-characterized biochemical cues. Hydrogels that mimic the native extracellular matrix can provide these mechanical cues to encapsulated cells,...
Volume electron microscopy [0.03%]
体视学法
Christopher J Peddie,Christel Genoud,Anna Kreshuk et al.
Christopher J Peddie et al.
Life exists in three dimensions, but until the turn of the century most electron microscopy methods provided only 2D image data. Recently, electron microscopy techniques capable of delving deep into the structure of cells and tissues have e...
Zixuan Zhao,Xinyi Chen,Anna M Dowbaj et al.
Zixuan Zhao et al.
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissect...
Mendelian randomization [0.03%]
孟德尔随机化研究
Eleanor Sanderson,M Maria Glymour,Michael V Holmes et al.
Eleanor Sanderson et al.
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and ...
Peptidomics [0.03%]
肽组学
Roland Hellinger,Arnar Sigurdsson,Wenxin Wu et al.
Roland Hellinger et al.
Peptides are biopolymers, typically consisting of 2-50 amino acids. They are biologically produced by the cellular ribosomal machinery or by non-ribosomal enzymes and, sometimes, other dedicated ligases. Peptides are arranged as linear chai...
Christoph Bock,Paul Datlinger,Florence Chardon et al.
Christoph Bock et al.
CRISPR screens are a powerful source of biological discovery, enabling the unbiased interrogation of gene function in a wide range of applications and species. In pooled CRISPR screens, various genetically encoded perturbations are introduc...
Rosana S Molina,Gordon Rix,Amanuella A Mengiste et al.
Rosana S Molina et al.