Hui Li,Kuangwen Hsieh,Pak Kin Wong et al.
Hui Li et al.
Bacterial infections and antimicrobial resistance are a major cause for morbidity and mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where physicians empirically treat suspected bacterial infections wi...
Brillouin microscopy [0.03%]
布里渊显微镜
Irina Kabakova,Jitao Zhang,Yuchen Xiang et al.
Irina Kabakova et al.
The field of Brillouin microscopy and imaging was established approximately 20 years ago, thanks to the development of non-scanning high-resolution optical spectrometers. Since then, the field has experienced rapid expansion, incorporating ...
Top-down proteomics [0.03%]
自上而下蛋白质组学
David S Roberts,Joseph A Loo,Yury O Tsybin et al.
David S Roberts et al.
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is essential to unravel the intricacies of biological system...
Sulfur fluoride exchange [0.03%]
硫氟交换反应
Joshua A Homer,Long Xu,Namitharan Kayambu et al.
Joshua A Homer et al.
Sulfur Fluoride Exchange (SuFEx) is a click reaction par excellence that has revolutionized multiple research fields. In this Primer, we delve into the essential elements of SuFEx operation, catalysis, and SuFExable connective hubs. We also...
Liesbeth Minnoye,Georgi K Marinov,Thomas Krausgruber et al.
Liesbeth Minnoye et al.
Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied characteristic of the eukaryotic genome. As active regulatory DNA elements are generally 'accessible', the genome-wide profiling of chromatin accessib...
Jessica C Hsu,Zhongmin Tang,Olga E Eremina et al.
Jessica C Hsu et al.
Medical imaging, which empowers the detection of physiological and pathological processes within living subjects, has a vital role in both preclinical and clinical diagnostics. Contrast agents are often needed to accompany anatomical data w...
Christine Grienberger,Andrea Giovannucci,William Zeiger et al.
Christine Grienberger et al.
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal activity in the intact brain. It is based on the principle that, when neurons fire action potentials, intracellular calcium levels rise, which can be detec...
Gabriela Romero,Jimin Park,Florian Koehler et al.
Gabriela Romero et al.
Weak magnetic fields offer nearly lossless transmission of signals within biological tissue. Magnetic nanomaterials are capable of transducing magnetic fields into a range of biologically relevant signals in vitro and in vivo. These nanotra...
M C DeRosa,A Lin,P Mallikaratchy et al.
M C DeRosa et al.
The introduction of the in-vitro evolution method known as SELEX (Systematic Evolution of Ligands by Exponential enrichment) more than 30 years ago led to the conception of versatile synthetic receptors known as aptamers. Offering many bene...
Valentina Emiliani,Emilia Entcheva,Rainer Hedrich et al.
Valentina Emiliani et al.
Optogenetic techniques have been developed to allow control over the activity of selected cells within a highly heterogeneous tissue, using a combination of genetic engineering and light. Optogenetics employs natural and engineered photorec...