Jonathan C M Wan,Nicholas McGranahan,Charles Swanton
Jonathan C M Wan
Intratumor heterogeneity poses a fundamental challenge across the cancer care continuum, from diagnosis to treatment resistance and metastasis. Over recent decades, multiregion and multiomic profiling of tissue, together with functional stu...
Insights from the ESMO Targeted Anticancer Therapies Asia Congress 2026 [0.03%]
2026年ESMO精准肿瘤疗法亚洲大会的见解
Vincenzo Giacco
Vincenzo Giacco
Fc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote antitumor immunity [0.03%]
经FC优化的GITR抗体可增强CD4T细胞和树突状细胞之间的交叉对话以促进抗肿瘤免疫反应
Yahel Avraham,Natasha Barth,Tzlil Yair Bar-On et al.
Yahel Avraham et al.
Targeting the stimulatory immune checkpoint glucocorticoid-induced TNFR-related protein (GITR) using agonistic monoclonal antibodies (mAbs) is a promising strategy for cancer immunotherapy that activates effector T cells and eliminates regu...
Tumoral extracellular vesicles and particles reprogram interstitial macrophages in the lung to promote vascular permeability and metastasis [0.03%]
肿瘤来源的细胞外囊泡和颗粒通过重新编程肺间质巨噬细胞促进血管通透性和转移发生
Shani Dror,Inbal Wortzel,Serena Lucotti et al.
Shani Dror et al.
The mechanisms by which tumor-derived extracellular vesicles and particles (EVPs) promote vascular permeability during premetastatic niche formation remain unclear. Here, we show that tumor EVPs rapidly induce vascular leakiness within 1 h ...
Author Correction: IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial [0.03%]
IDH1突变疫苗治疗新诊断的星形细胞瘤：多中心、单组、开放性、首个人体Ⅰ期NOA16试验最终分析
Lukas Bunse,Katharina Lindner,Antje Wick et al.
Lukas Bunse et al.
Published Erratum
Nature cancer. 2026 Aug 3. DOI:10.1038/s43018-026-01227-x 2026
Sarada Achyutuni,Jian Xu
Sarada Achyutuni
Retraction Note: Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance [0.03%]
撤回 notice: 通过靶向 LGR4 激活铁死亡可针对结直肠癌获得性耐药克服药物耐受性
Hao Zheng,Jinming Liu,Qi Cheng et al.
Hao Zheng et al.
Emily B Derrick,Paul A Beavis
Emily B Derrick
Dalpiciclib plus endocrine therapy in women with HR+/HER2- advanced breast cancer and visceral crisis: a multicenter, nonrandomized, phase 2 DARVIN trial [0.03%]
用于治疗激素受体阳性/HER2阴性晚期乳腺癌合并脏器危象女性患者的方法：达尔芬二期临床试验中多中心非随机Dalpiciclib联合内分泌治疗的研究
Hongnan Mo,Yuee Teng,Li Cai et al.
Hongnan Mo et al.
Visceral crisis in advanced breast cancer (ABC) represents a major challenge. Here we conducted a phase 2 study to evaluate dalpiciclib plus endocrine therapy (ET) in women with HR+/HER2- ABC experiencing visceral crisis. The primary endpoi...
Androgen loss contributes to neuroinflammation and promotes brain tumor growth [0.03%]
雄激素丢失促炎性细胞因子的产生并促进脑肿瘤生长
Heathcliff Dorado García
Heathcliff Dorado García