Differentiation of Wharton's jelly-derived mesenchymal stromal cells into hepatocyte-like cells using a refined method [0.03%]
使用改进方法将沃顿胶来源的间充质基质细胞分化为肝样细胞
Afsoon Afshari,Negar Azarpira,Sara Pakbaz
Afsoon Afshari
Background: The production of functional hepatocyte cells in enough quantities is of paramount importance for the replacement of lost hepatocytes. In this investigation, a series of 7-mimic microRNAs was harnessed to indu...
Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave's disease and control [0.03%]
基于单细胞RNA测序评估XCI偏移并证明XCI逃逸区：女性Grave's病与正常对照比较
In-Cheol Baek,Soo Yeun Sim,Byung-Kyu Suh et al.
In-Cheol Baek et al.
Background: The reactivation and loss of mosaicism hypothesis due to X chromosome inactivation (XCI) skewing and escape could influence gender differences in autoimmune diseases. XCI selectively inactivates one of the two...
Comparative Study
BMC molecular and cell biology. 2025 Jan 31;26(1):8. DOI:10.1186/s12860-025-00533-z 2025
Method for determining of cytotoxicity based on the release of fluorescent proteins [0.03%]
基于荧光蛋白释放的细胞毒性测定方法
Dmitry Lifanov,Dulamsuren Zorigt,Evgenya Shabalina et al.
Dmitry Lifanov et al.
This paper describes a method for determining the cytotoxicity of chemical compounds based on the detection of fluorescent proteins-in this case, green fluorescent protein (GFP) and red fluorescent protein (RFP), which are released into the...
BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression [0.03%]
BRAF通过调控circPSD3/miR-526b/RAP2A轴抑制乳头状甲状腺癌进展
Chuang Li,Xiaojuan Zhao,Jingge Zhao et al.
Chuang Li et al.
Background: Papillary thyroid carcinoma (PTC) is a common malignant tumor. BRAFV600E mutation has become a common molecular event in PTC pathogenesis. Circular RNA PSD3 (circPSD3) is known to be highly expressed in PTC. H...
The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) [0.03%]
转录因子Atoh1促进人牙髓干细胞的牙原性分化
Camila Sabatini,Huey-Jiun Lin,Galib Ovik et al.
Camila Sabatini et al.
Background: Bioengineering of human teeth for replacement is an appealing regenerative approach in the era of gene therapy. Developmentally regulated transcription factors hold promise in the quest because these transcrip...
Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis [0.03%]
摩尔灵诱导的凋亡抵抗与YAP/TAZ瞬时激活相关
Hoyeon Lee,Sang Woo Cho,Hyo Sun Cha et al.
Hoyeon Lee et al.
Background: The Hippo signaling pathway involves a kinase cascade that controls phosphorylation of the effector proteins YAP and TAZ, leading to regulation of cell growth, tissue homeostasis, and apoptosis. Morusin, a com...
Functional significance of some common oxytocin receptor SNPs involved in complex human traits [0.03%]
与复杂人类性状相关的常见催产素受体SNP的功能意义
Suk Ling Ma,Michael Thomas Bowen,Mark R Dadds
Suk Ling Ma
Background: Oxytocin function is associated with a range of human traits and is often indexed by common polymorphisms of the receptor gene OXTR. Little is known however about the functional significance of these polymorph...
Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes [0.03%]
小鼠卵母细胞从NSN到SN过渡期间的转录组和DNA甲基化谱分析
Hannah Demond,Soumen Khan,Juan Castillo-Fernandez et al.
Hannah Demond et al.
Background: During the latter stages of their development, mammalian oocytes under dramatic chromatin reconfiguration, transitioning from a non-surrounded nucleolus (NSN) to a surrounded nucleolus (SN) stage, and concomit...
Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome [0.03%]
致命和非致死型赖恩综合征家系的Fam20c敲入小鼠模型
Mengnan Chen,Dongmei Sun,Siu-Pok Yee et al.
Mengnan Chen et al.
Background: Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia or non-lethal hypophosphatemia rickets. However, it is only hypophosphatemia rickets tha...
Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis [0.03%]
单细胞RNA测序在骨关节炎软骨细胞亚群中鉴定血红蛋白的表达
Zhihao Zhang,Ting He,Hongwen Gu et al.
Zhihao Zhang et al.
In recent years, chondrocytes have been found to contain hemoglobin, which might be an alternative strategy for adapting to the hypoxic environment, while the potential mechanisms of that is still unclear. Here, we report the expression cha...