RBM39 upregulation promotes ostium re-obstruction after endoscopic endonasal dacryocystorhinostomy (En-DCR) [0.03%]
RBM39上调促进经鼻内镜 dacryocystorhinostomy (En-DCR) 术后再狭窄
Jinjie Liu,Jinzhi Zhao,Xiaoyu Zhu et al.
Jinjie Liu et al.
Purpose: Chronic dacryocystitis, characterized by epiphora, is primarily treated with dacryocystorhinostomy (DCR), yet postoperative anastomotic re-obstruction remains a significant cause of failure. This study aimed to i...
From microscope to model: rotating signaling dynamics and cluster size in Dictyostelium discoideum aggregates [0.03%]
从显微镜到模型：Dictyostelium discoideum聚集体中的旋转信号动态和集群大小关系研究
Sanchi Saitia,Yi-Chieh Lai,Man-Ho Tang et al.
Sanchi Saitia et al.
Background: When starved, Dictyostelium discoideum cells form clusters that, when constrained in height, exhibit clear collective rotational motion. During this collective rotation, cells secrete and relay the chemoattrac...
A goat-derived gamma-tubulin antibody for triple-channel imaging of primary cilia [0.03%]
用于初级纤毛三重通道成像的来源于山羊的gamma-微管蛋白抗体
Eliza Karapetian,Christoph Gerhardt,Natalia Lemanska et al.
Eliza Karapetian et al.
Background: Primary cilia are essential sensory organelles, and their dysfunction leads to a broad spectrum of diseases known as ciliopathies. Immunofluorescence imaging of ciliary substructures is a key tool in cilia res...
Hypoxia-pretreated exosomes promote enterocutaneous fistula healing via regulating inflammation and tissue repair [0.03%]
缺氧预处理外泌体通过调节炎症和组织修复促进肠瘘愈合
Yankui Liu,Beini Zhu,Hongbin Liu et al.
Yankui Liu et al.
Background: Enterocutaneous fistula (ECF) is an abnormal pathological passage. This study aims to investigate the role and mechanism of action of gelatin sponges loaded with hypoxic exosomes (GS-Hypo-Exos) in the treatmen...
Jana Rohe,Arsila Palliyulla Kariat Ashraf,Melina Kehl et al.
Jana Rohe et al.
Background: Renal cyst formation, as observed in autosomal dominant polycystic kidney disease (ADPKD), is a life-threatening condition with no effective cure yet. The molecular mechanisms underlying primary cilia dysfunct...
Differential phosphorylation of PHIP phosphopeptides with implications in insulin signaling [0.03%]
PHIP磷酸肽的差异性磷酸化及其在胰岛素信号转导中的作用
Ayadathil Sujina,Amal Fahma,Suhail Subair et al.
Ayadathil Sujina et al.
Background: PHIP (PH Interacting Protein) is an Insulin Receptor Substrate 1 (IRS1) interactor protein that binds to acetylated IRS1 through its bromodomain. Due to its involvement in insulin signaling pathway, it is impl...
Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions [0.03%]
TAK-242对急性炎性条件下骨髓间充质干细胞成骨作用的免疫调节效应
Mahsa Ghiasvand,Maryam Talebi Jouybari,Mahmood Talkhabi et al.
Mahsa Ghiasvand et al.
Background: Bone regeneration involves a complex series of stages that need proper regulation of the acute inflammatory response. Toll-like receptor 4 (TLR4) is expressed in cells necessary for bone metabolism and modulat...
Alcohol exposure induces ferroptosis-dominated programmed cell death in esophageal epithelial cells [0.03%]
酒精暴露可诱导食道上皮细胞发生铁死亡为主的程序性细胞死亡
Dongxue Wang,Zhenyu Jiang,Zhiyi Meng et al.
Dongxue Wang et al.
Chemoradiotherapy-induced Th17/IL-17 signaling correlates with therapeutic tolerance and early recurrence in cervical carcinoma [0.03%]
宫颈癌的化学放射诱导的Th17/IL-17信号与治疗耐受和早期复发相关性研究
Fanglei Cao,Na Li
Fanglei Cao
This study investigates the role of Th17 cells and IL-17 signaling in mediating therapeutic resistance and early recurrence in cervical carcinoma. Th17 cells were generated in vitro, and cervical carcinoma cells were subsequently exposed to...
Telomere-to-telomere characterization of rDNA chromosome in the myxomycete Didymium iridis [0.03%]
轮虫霉Dictyditella iridis rDNA染色体的端到端解析
Arif Khan,Tor Erik Jørgensen,Lars Martin Jakt et al.
Arif Khan et al.
Background: The ribosomal DNA (rDNA) of the myxomycete Didymium iridis is located on a linear, multi-copy, non-Mendelian chromosome. Efforts to determine the complete sequence by short-read sequencing technologies have be...