Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn's disease-associated Escherichia coli [0.03%]
乳酸菌和裂殖酵母对克罗恩病相关大肠杆菌诱导的结肠细胞炎性作用的影响
Samira Alipour,Hossein Halimi,Nastaran Asri et al.
Samira Alipour et al.
Background: Adherent-invasive Escherichia coli (AIEC) is linked to intestinal inflammation in inflammatory bowel disease (IBD). Arthrospira platensis and Lactobacillus helveticus exhibit anti-inflammatory properties indiv...
Sex alters thyroid hormone's effect on protein O-GlcNAcylation in the aged mouse heart [0.03%]
性行为改变甲状腺激素对老年小鼠心脏蛋白质O-连接的N-乙酰氨基葡萄糖修饰的影响
Aaron K Olson,Wei Zhong Zhu,Dolena Ledee
Aaron K Olson
Background: The aging heart undergoes physiological changes, many of which are sex dependent and encompass differential responses to cardiac stress. However, much about the molecular changes that occur within the aging he...
Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells [0.03%]
短链3-羟基酰基辅酶A脱氢酶(SCHAD)蛋白互作伙伴的筛选及与角蛋白8在胰岛β细胞中相互作用研究
Kelly Velasco,Janniche Torsvik,Johanna L St-Louis et al.
Kelly Velasco et al.
Background: Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a ubiquitously expressed mitochondrial enzyme with a role in the degradation of fatty acids. Because the protein also is a negative regulator of insulin s...
TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV disease [0.03%]
HIV感染者中TRAIL（DR5）受体及调变TRAIL途径：HIV疾病进展中的关键机制
Sarah Ratkovich-Gonzalez,Mariana Del Rocio Ruiz-Briseño,Judith Carolina De Arcos-Jiménez et al.
Sarah Ratkovich-Gonzalez et al.
Background: HIV infection is mainly described by depletion of CD4+ T-cells; however, this not only occurs in infected cells, also arise in uninfected immunological cells through the bystander effect. Extrinsic cell death,...
Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis [0.03%]
RNase A样和胰蛋白酶样丝氨酸蛋白酶的保守结构拓扑：基于序列的折叠分析
K M Ahsanul Kabir,Takuya Takahashi,Takeshi Kikuchi
K M Ahsanul Kabir
Background: Protein folding is a complex process in which amino acid sequences encode the information required for a polypeptide chain to fold into its functional three-dimensional (3D) structure. Many proteins share comm...
The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness [0.03%]
FMNL2佛mlin2蛋白在黑色素瘤细胞适应基底硬度变化过程中发挥重要作用
Joshua D Clugston,Sarah Fox,James L Harden et al.
Joshua D Clugston et al.
Background: Cells constantly sense and respond to changes in their local environment to adapt their behaviour and morphology. These external stimuli include chemical and mechanical signals, and much recent work has reveal...
PYGO2 regulates IL10 and plays immunosuppressive role through ESCC progression [0.03%]
PYGO2调节IL10并通过抑制食管癌进展发挥免疫抑制作用
Fereshteh Ahmadian Shalchi,Nayyerehalsadat Hosseini,Fatemeh Nourmohammadi et al.
Fereshteh Ahmadian Shalchi et al.
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive carcinomas of the gastrointestinal tract, is the sixth most common cause of cancer-related death. Wnt pathway plays a pivotal role in cell ...
N-actylcysteine inhibits diethyl phthalate-induced inflammation via JNK and STAT pathway in RAW264.7 macrophages [0.03%]
N-乙酰半胱氨酸通过RAW264.7巨噬细胞中的JNK和STAT途径抑制邻苯二甲酸二正丁酯引起的炎症反应
Jin Hee Kim,Jae Hoon Lee,Yoon Jung Koo et al.
Jin Hee Kim et al.
Background: Phthalates are plasticizers that cause inflammation in several cell types and adversely affect the health of humans and animals. Nacetylcysteine (NAC) has been shown to exert antioxidant effects in various dis...
Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells [0.03%]
犬肠类器官作为研究上皮细胞MHC II类分子表达的平台
Meg Nakazawa,Itsuma Nagao,Yoko M Ambrosini
Meg Nakazawa
Backgrounds: The interplay between intestinal epithelial cells (IECs), the immune system, and the gut microbiome is pivotal for maintaining gastrointestinal homeostasis and mediating responses to ingested antigens. IECs, ...
Quantitative phosphoproteomics reveals that nestin is a downstream target of dual leucine zipper kinase during retinoic acid-induced neuronal differentiation of Neuro-2a cells [0.03%]
定量磷酸蛋白质组学揭示了巢蛋白是视网酸诱导的神经母细胞瘤2a细胞神经分化过程中双亮氨酸拉链激酶的下游靶点
Guillaume St-Cyr,Daniel Garneau,Nicolas Gévry et al.
Guillaume St-Cyr et al.
Background: Dual leucine zipper kinase (DLK) is critical for neurite outgrowth in the developing nervous system and during nerve regeneration, but the underlying mechanisms remain largely unknown. To address this issue, w...