Rachel K MacKenzie,Parvathy Ravi Sankar,Andrew J Bendall
Rachel K MacKenzie
Background: Dlx5 and Dlx6 stimulate differentiation of diverse progenitors during embryonic development. Their actions as pro-differentiation transcription factors includes the up-regulation of differentiation markers but...
Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9 [0.03%]
CRISPR/Cas9基因编辑高效纠正 Yorkshire猪肾细胞中450kb的KIT结构变异
Ke Qin,Xinyu Liang,Guanjie Sun et al.
Ke Qin et al.
The white coat colour of Yorkshire and Landrace pig breeds is caused by the dominant white I allele of KIT, associated with 450-kb duplications and a splice mutation (G > A) at the first base in intron 17. To test whether genome editing can...
Generation and maintenance of acentric stable double minutes from chromosome arms in inter-species hybrid cells [0.03%]
异种杂交细胞中染色体臂衍生的非端粒稳定双微体的产生及维持
Noriaki Shimizu,Rita Kapoor,Shuhei Naniwa et al.
Noriaki Shimizu et al.
Background: Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis)...
Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells [0.03%]
压缩和拉伸通过miR-3198改变牙周韧带细胞中Osteoprotegerin的表达
Hiroyuki Kanzaki,Satoshi Wada,Yuuki Yamaguchi et al.
Hiroyuki Kanzaki et al.
Background: Osteoclasts play a critical role in bone resorption due to orthodontic tooth movement (OTM). In OTM, a force is exerted on the tooth, creating compression of the periodontal ligament (PDL) on one side of the t...
Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge [0.03%]
感染传染性支气管炎病毒后蛋鸡泄殖腔器官中参与线粒体生物合成和功能的基因可能不会表现出同步应答反应
Samiullah Khan,Juliet Roberts,Shu-Biao Wu
Samiullah Khan
Background: Egg formation takes place in the oviduct of laying hens over a 24 h period. Infectious bronchitis virus (IBV) causes pathological lesions in the chicken oviduct. In the current study, mitochondrial counts were...
Downregulation of lncRNA CCAT1 enhances 5-fluorouracil sensitivity in human colon cancer cells [0.03%]
lncRNA CCAT1表达沉默可增强人结肠癌细胞对氟尿嘧啶的敏感性
Chun Yang,Yong Pan,Shao Ping Deng
Chun Yang
Background: The purpose of this study was to determine the aberrant expression of the long noncoding RNA (lncRNA) colon cancer-associated transcript 1 (CCAT1) in 5-fluorouracil-resistant colonic neoplasm cells and to eluc...