Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy [0.03%]
褪黑素通过调节自噬减少1型糖尿病小鼠的肺损伤
Jafar Rezaie,Mojtaba Jahanghiri,Reza Mosaddeghi- Heris et al.
Jafar Rezaie et al.
Background: In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells [0.03%]
机械牵张导致血管平滑肌细胞来源的胞外囊泡中的洞穴蛋白-1含量增加及矿化潜能提高
Mohammad Shaver,Kassandra Gomez,Katherine Kaiser et al.
Mohammad Shaver et al.
Background: Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural compo...
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis [0.03%]
前列腺癌中组合疗法的优化：紫杉醇和萝卜硫素诱导的凋亡协同效应的作用机制研究
Tito N Habib,Mohammed O Altonsy,Salah A Ghanem et al.
Tito N Habib et al.
Background: Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance compared to monotherapy. This study explores the potential of...
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells [0.03%]
巨噬细胞诱导的A549细胞中TonEBP/NFAT5表达与顺铂耐药性和迁移有关
Hee Ju Song,Young Hwan Kim,Han Na Choi et al.
Hee Ju Song et al.
Background: Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal carcinoma and colon cancer cells. However, the role of this transcripti...
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC [0.03%]
CTC与Shh和Nrf2一起是HNSCC的潜在诊断标志物
Md Mizanur Rahman,Muhammad Mosaraf Hossain,Shafiqul Islam et al.
Md Mizanur Rahman et al.
Background: The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considera...
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis [0.03%]
通过蛋白质组规模的网络分析在残基水平上优先处理布鲁氏锥虫编辑体蛋白相互作用界面
Naghmeh Poorinmohammad,Reza Salavati
Naghmeh Poorinmohammad
Background: Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge due to drug resistance. While identifying novel drug targets is vital, the process is d...
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function [0.03%]
SAP130的类泛素化调节其与FAF1的相互作用及其蛋白稳定性及转录抑制功能
Chang-Han Chen,Hung-Wei Lin,Meng-Fang Huang et al.
Chang-Han Chen et al.
Background: Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...
Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder [0.03%]
Dec1的丢失抑制酒精诱导的肝脏脂质蓄积和生物钟紊乱
Fuyuki Sato,Ujjal K Bhawal,Kosuke Oikawa et al.
Fuyuki Sato et al.
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC1, a basic helix-loop-helix tra...
Association between plasma L-carnitine levels and mitochondrial DNA copy number [0.03%]
左卡尼汀水平与线粒体DNA拷贝数关系的研究
Mingyue Li,Keming Yang,Immaculata De Vivo et al.
Mingyue Li et al.
Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy number (mtDNAcn) is considered a b...
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells [0.03%]
EMI1基因沉默对人乳腺癌细胞增殖和侵袭的影响
Ying Kuang,Shengwen Huang,Shifan Tang et al.
Ying Kuang et al.
Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The present study investigated the effects of the decreased expression...