Age-Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice [0.03%]
小鼠髓系细胞随年龄变化及其对皮下黑色素瘤生长的影响
Kaitlyn M Landreth,Dylan D Thomas,Remi Nohoesu et al.
Kaitlyn M Landreth et al.
Background: Advancing age increases cancer risk due to DNA damage accumulation and a decline in immune function. While aging is known to reduce adaptive immunity, it also leads to an increase in immunosuppressive myeloid ...
Catherine Pham-Danis,Shi B Chia,Hannah A Scarborough et al.
Catherine Pham-Danis et al.
Background: Lung cancer is the leading cause of cancer death in the world. While cigarette smoking is the major preventable factor for cancers in general and lung cancer in particular, old age is also a major risk factor....
Gena M Dominique,Catherine Hammond,M Sharon Stack
Gena M Dominique
The gut microbiome changes with age and affects regions beyond the gut, including the ovarian cancer tumor microenvironment. In this review summarizing the literature on the gut microbiome in ovarian cancer and in aging, we note trends in t...
Allostatic load and risk of all-cause, cancer-specific, and cardiovascular mortality in older cancer survivors: an analysis of the National Health and Nutrition Examination Survey 1999-2010 [0.03%]
全国健康和营养检查调查（1999-2010）中的 allostatic 负荷与老年癌症幸存者的全因、癌症特异性和心血管疾病死亡率之间的关系：一项分析研究
Danting Yang,Meghann Wheeler,Shama D Karanth et al.
Danting Yang et al.
Background: Allostatic load has been linked to an increased risk of death in various populations. However, to date, there is no research specifically investigating the effect of allostatic load on mortality in older cance...
Immune checkpoint expression and relationships to anti-PD-L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice [0.03%]
老龄与年轻小鼠的免疫检查点表达及其对PD-L1免疫检查点抑制剂癌症免疫治疗疗效的影响关系
Myrna G Garcia,Yilun Deng,Clare Murray et al.
Myrna G Garcia et al.
Introduction: Aging is the biggest cancer risk, and immune checkpoint (IC) inhibition (ICI) is a revolutionary cancer immunotherapy approach. Nonetheless, there are limited preclinical/clinical data regarding aging effect...
Patterns of treatment in older patients with newly diagnosed advanced bladder cancer: A SEER dataset analysis [0.03%]
基于SEER数据库的新诊断晚期膀胱癌老年患者的治疗模式分析
Elizabeth R Kessler,Sarah J Schmiege,Megan Eguchi et al.
Elizabeth R Kessler et al.
Background: Bladder cancer is one of the top 10 cancers diagnosed in Americans with a median age of 73. This is the patient population that tends to be older with multiple medical conditions, and previously described vari...
The impact of Omicron pandemic and COVID-19 vaccination on the pancreatic adenocarcinoma patients [0.03%]
Omicron疫情影响及COVID-19疫苗接种对胰腺导管腺癌患者的影响
Ningzhen Fu,Yu Jiang,Zhiwei Xu et al.
Ningzhen Fu et al.
Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in enormous medical and economic burden worldwide during the past 3 years. The vaccination was deemed the effective option to prevent the severe sympto...
FOXO3 regulates a common genomic program in aging and glioblastoma stem cells [0.03%]
FOXO3在衰老和多形性胶质母细胞瘤干细胞中调节共同的基因组程序
Amanda J Audesse,Galina Karashchuk,Zachary A Gardell et al.
Amanda J Audesse et al.
Background: Glioblastoma (GBM) is an aggressive, age-associated malignant glioma that contains populations of cancer stem cells. These glioma stem cells (GSCs) evade therapeutic interventions and repopulate tumors due to ...
Another Wrinkle with Age: Aged Collagen and Intra-peritoneal Metastasis of Ovarian Cancer [0.03%]
卵巢癌腹腔内转移与老化胶原的关系
Elizabeth I Harper,Tyvette S Hilliard,Emma F Sheedy et al.
Elizabeth I Harper et al.
Background: Age is the most significant risk factor for ovarian cancer (OvCa), the deadliest gynecologic malignancy. Metastasizing OvCa cells adhere to the omentum, a peritoneal structure rich in collagen, adipocytes, and...
Dejana Braithwaite,Stephen Anton,Supriya Mohile et al.
Dejana Braithwaite et al.
Background: The intersection of cancer and aging is an emerging public health challenge in developed countries because of the aging and expansion of the population. ...