Ring Opening Functionalization of Thiolactone Homopolymers for ROS Scavenging [0.03%]
用于清除活性氧的硫内酯均聚物开环功能化研究
Aaron Priester,Forrest Kievit,Anthony J Convertine
Aaron Priester
In this research, we explored the synthesis and application of thiolactone acrylamide (TLA) polymers for neutralizing reactive oxygen species (ROS), produced as a result of traumatic brain injury (TBI). We synthesized well-defined TLA polym...
Ring-Opening Metathesis Polymerization of Levoglucosenone-Derived Enyne Monomers [0.03%]
由糠醛衍生的烯炔单体的开环元聚合
Alec B Pabarue,Xuelin Sui,Yilei Bu et al.
Alec B Pabarue et al.
Levoglucosenone (LGO) has emerged as a versatile synthon in target-oriented synthesis due to its availability from cellulose. While its functionality and chirality have found direct use as a small molecule building block, translation to pol...
Solution-like Water Transport Across Molecular to Macroscopic Length Scales in Crosslinked Poly(ethylene glycol diacrylate) Networks with Tailored Sidechains [0.03%]
具有功能侧链的交联聚（乙二醇二丙烯酸酯）网络中的类溶液输运行为：从分子尺度到宏观尺度
Thomas R Webber,Declan P Shannon,Leo W Gordon et al.
Thomas R Webber et al.
Poly(ethylene glycol) (PEG)-based materials, like PEG-diacrylate (PEGDA), are prized for their hydrophilic, inert properties, and leveraged in hydrogels and as membrane mimics. While network chemistry is often tuned for selective transport ...
Cristina-Maria Hirschbiegel,Ritabrita Goswami,Soham Chakraborty et al.
Cristina-Maria Hirschbiegel et al.
Synthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide bioorthogonal nanocatalysts. These 'polyzymes' catalyze the in situ generation of therapeutic agents without disrupting native biological processes. Th...
Brandon R Clarke,Gregory N Tew
Brandon R Clarke
Polymer networks remain an essential class of soft materials. Despite their use in everyday materials, connecting the molecular structure of the network to its macroscopic properties remains an active area of research. Much current research...
Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery [0.03%]
用作药物输送中PEG替代品的两性离子聚合物的生物可降解性研究
Ziwen Zhang,Haotian Sun,Justin Giannino et al.
Ziwen Zhang et al.
Poly(ethylene glycol) (PEG) is a highly biocompatible and water-soluble polymer that is widely utilized for biomedical applications. Unfortunately, the immunogenicity and antigenicity of PEG severely restrict the biomedical efficacy of pegy...
Lens epithelial cell response to polymer stiffness and polymer chemistry [0.03%]
lens上皮细胞对聚合物刚度和聚合物化学成分的反应
Hamid Hamedi,Spencer W Green,Raima Puri et al.
Hamid Hamedi et al.
Posterior capsule opacification (PCO) is the most common complication of cataract surgery, and intraocular lens (IOL) implantation is the standard of care for cataract patients. Induction of post-operative epithelial-mesenchymal transition ...
Removal of photoredox catalysts from polymers synthesized by organocatalyzed atom transfer radical polymerization [0.03%]
从有机催化的原子转移自由基聚合合成的聚合物中去除光氧化还原催化剂
Katherine A Chism,Daniel A Corbin,Garret M Miyake
Katherine A Chism
Organocatalyzed atom transfer radical polymerization (O-ATRP) is a method of producing polymers with precise structures under mild conditions using organic photoredox catalysts (PCs). Due to the unknown toxicity of PCs and their propensity ...
Synthesis and characterization of poly(ethylene glycol) bottlebrush networks via ring-opening metathesis polymerization [0.03%]
通过开环元聚合合成和表征聚乙二醇瓶刷网络结构聚集体
Brandon R Clarke,Gregory N Tew
Brandon R Clarke
Herein it is reported how the overlap concentration (C*) can be used to overcome crosslinking due to diol impurities in commercial PEG, allowing for the synthesize of bottlebrush polymers with good control over molecular weight. Additionall...
Paul Strasser,Oliver Plavcan,Edip Ajvazi et al.
Paul Strasser et al.
The control of chain-ends is fundamental in modern macromolecular chemistry for directed one-to-one bioconjugation and the synthesis of advanced architectures such as block copolymers or bottlebrush polymers and the preparation of advanced ...