Evolution of Therapy for ANCA-Associated Vasculitis with Kidney Involvement [0.03%]
抗中性粒细胞胞浆抗体相关血管炎肾脏损害的治疗进展
Arun Rajasekaran,Dana V Rizk
Arun Rajasekaran
ANCA-associated vasculitis (AAV) belongs to a group of small vessel systemic vasculitides characterized by granulomatous and neutrophilic inflammation of various tissues. Patients often have circulating autoantibodies targeting neutrophilic...
Local Inflammation But Not Kidney Cell Infection Associated with High APOL1 Expression in COVID-Associated Nephropathy [0.03%]
与高APOL1表达相关的局部炎症而非肾脏细胞感染在新冠相关性肾病中的作用
Jane K Nguyen,Zhenzhen Wu,Jose Agudelo et al.
Jane K Nguyen et al.
In coronavirus disease-19 biopsies, detection of severe acute respiratory syndrome coronavirus 2 was rare with no evidence of viral replication, whereas autopsy tissue failed quality control.In patients with FSGS, apolipoprotein L1 expressi...
Occupational Heat Stress Recommendation Compliance Attenuates AKI Risk Compared with a Work-Rest Ratio-Matched, Positive Control Scenario [0.03%]
与工作休息比匹配的阳性对照方案相比，职业性中暑危险度管理可降低急性肾损伤风险
Hayden W Hess,Tyler B Baker,Macie L Tarr et al.
Hayden W Hess et al.
Occupational heat stress recommendations attenuate AKI risk compared with a work–rest ratio–matched positive control scenario.Heat-induced AKI risk is strongly related to peak core temperature.The peak change in serum creatinine largely p...
Charlotte Thomas,Rafia Ali,Isabel Park et al.
Charlotte Thomas et al.
Key Points: Patients testing positive for platelet factor 4 antibodies have a >50% higher odds of developing severe AKI compared with those who test negative.The relationship between platelet factor 4 antibodies and seve...
A Nef Precursor or Benign Counterpart: High Prevalence of Healthy Subjects with Antibody Reactivity to the C3-Convertase [0.03%]
Nef前体或良性对应物：补体C3转化酶抗体阳性的健康人群的高发率
Christopher T Culek,Carla M Nester
Christopher T Culek
There are two anticonvertase antibody populations—Nephritic Factors which cause complement dysregulation and C3CAbs which do not.C3CAbs are highly prevalent in the healthy adult population (>95% prevalence).C3CAbs suggest a direction of st...
Elliot Koranteng Tannor,Sampson Antwi
Elliot Koranteng Tannor
Spatial Heterogeneity of Glomerular Phenotypes Affects Kidney Biopsy Findings [0.03%]
肾小球表型的空间异质性影响肾脏活检结果
Jennifer A Schaub,Christopher L O&#x;Connor,Meghan Dailey et al.
Jennifer A Schaub et al.
Key Points: Glomeruli with pathologic changes are not homogeneously distributed throughout the kidney cortex.Biopsies that do not include the kidney capsule may underdetect glomeruli with pathologic changes.Location of g...
Gender Disparities in Nephrology Trials: A Meta-Analysis of Enrollment Trends between 2000 and 2021 [0.03%]
肾病试验中的性别差异：2000年至2021年入组趋势的meta分析
Qandeel H Soomro,Angela McCarthy,Amalya M Charytan et al.
Qandeel H Soomro et al.
Key Points: Women are under-represented in high-impact nephrology trials.Trends remain consistent over the past 20 years and on the basis of target condition.Addressing the imbalanced enrollment of women in trials could ...
Meta-Analysis
Kidney360. 2023 Nov 1;4(11):1545-1553. DOI:10.34067/KID.0000000000000281 2023
Association of Plant-Based Protein Intake with Cognitive Function in Adults with CKD [0.03%]
基于植物的蛋白质摄入与CKD成人认知功能的关系
Luis Perez,Zhiying You,Jessica Kendrick
Luis Perez
Key Points: Higher plant protein intake was associated with higher cognitive scores in people with kidney disease.Future trials are needed to determine whether increasing plant protein intake improves measures of cogniti...
Pathways Project Pragmatic Lessons Learned: Integrating Supportive Care Best Practices into Real-World Kidney Care [0.03%]
路径优化项目的经验教训：在现实肾脏疾病护理中融入最佳支持性治疗方案
Alvin H Moss,Glenda Harbert,Annette Aldous et al.
Alvin H Moss et al.
Key Points: A multisite quality improvement project using the Institute for Healthcare Improvement learning collaborative structure helped kidney care teams identify seriously ill patients and implement supportive care b...