Light-Activated Nucleic Acid Amplification Systems Using Photo-Caged DNA Polymerase or Primers [0.03%]
基于紫外光激活的核酸扩增系统及其在单分子核酸测序中的应用研究
Yang Wu,Meng Wu,Yukun Tian et al.
Yang Wu et al.
Precise control over nucleic acid amplification is essential for achieving reliable, quantitative, high-throughput, and multiplexed molecular diagnostics, particularly in point-of-care and field settings. However, conventional isothermal am...
Feature Cover: Light-Activated Nucleic Acid Amplification Systems Using Photo-Caged DNA Polymerase or Primers (Advanced Genetics 2/07) [0.03%]
封面故事：光活化核酸扩增系统使用光阻DNA聚合酶或引物
Yang Wu,Meng Wu,Yukun Tian et al.
Yang Wu et al.
Light-Activated Nucleic Acid Amplification: Making Molecular Diagnostics "Start on Light" The cover artwork illustrates a light-triggered nucleic acid amplification platform in which dormant photo-caged DNA polymerases or primers are rapidl...
Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons [0.03%]
遗传性骨病的范畴 review：病理、症状、诊断、治疗及新视野
Colin Jones,Ambalangodage C Jayasuriya
Colin Jones
Genetic bone diseases are a rare group of afflictions suffered by the general population. However, their rarity should not diminish research efforts to help patients understand and treat their diseases. This review summarizes the pathology,...
Compact Cas12 Systems for Multiplex Engineering of Plant Abiotic-Stress Networks [0.03%]
用于植物非生物胁迫网络多重工程的精简Cas12系统
Samar G Thabet,Khairiah Mubarak Alwutayd,Amr Elkelish et al.
Samar G Thabet et al.
Compact CRISPR-Cas12 platforms, particularly miniature and hypercompact effectors such as Cas12f, Cas12j/CasPhi, and Cas12lambda, are emerging as delivery-efficient tools for plant genome engineering because their reduced coding size facili...
Locus-Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder [0.03%]
精神分裂症和双相情感障碍的DAOA基因位点特异性遗传关联
Madiha Khalid,Muhammad Mukhtar,Muhammad Saqlain et al.
Madiha Khalid et al.
DAOA gene has been implicated in both schizophrenia (SZ) and bipolar disorder (BD), where genetic variants were associated with each disorder individually. However, the common variants shared between SZ and BD within this gene remain undere...
Mapping Meiotic Recombination DNA Double-Strand Breaks (DSBs) Hotspots -Methodological Advances and Challenges [0.03%]
绘图：方法学进展与挑战
Jianqiang Bao
Jianqiang Bao
Programmed DNA double-strand breaks (DSBs) initiate meiotic recombination at discrete genomic hotspots, and their precise mapping is crucial for understanding the molecular regulation of genome stability and evolution. A variety of genome-w...
PDMSA: A Web-Based Tool for Pan-Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers [0.03%]
PDMSA：一种基于网络的工具，用于使用DNA甲基化水平作为生物标志物的泛癌症生存分析
Weiwei Guo,Ying Shi,Shanshan Wu et al.
Weiwei Guo et al.
DNA methylation levels are intimately associated with tumor development, progression, and therapeutic outcomes. Accurate analysis of the relationship between DNA methylation levels and tumor prognosis facilitates comprehensive investigation...
Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress [0.03%]
抗氧化是机械应力下不同物种的共同防御策略
Feixiang Zhu,Kai Huang
Feixiang Zhu
Mechanical stress, a ubiquitous physical stimulus, triggers oxidative stress through mechanotransduction in diverse organisms, driving the evolution of antioxidant defense systems. This perspective deciphers the molecular evolutionary princ...
From Disease-Specific Models to Broad Clinical Utility: A Perspective on AI Hybrid Ensemble Frameworks [0.03%]
从特定疾病的模型到广泛临床应用：AI混合集成框架展望
Haonan Zhang,Ge Zhang,Chaoyang Yu et al.
Haonan Zhang et al.
Artificial intelligence (AI) has advanced predictive modeling in medicine, yet many models remain disease-specific and difficult to generalize across clinical settings. Key challenges include the trade-off between interpretability and accur...
Front Cover: PDMSA: A Web-Based Tool for Pan-Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers (Advanced Genetics 2/07) [0.03%]
封面故事：PDMSA：基于web的泛癌生存分析工具（利用dna甲基化水平作为生物标志物）(《_advanced genetics》第7期，总第2期)
Weiwei Guo,Ying Shi,Shanshan Wu et al.
Weiwei Guo et al.
A Pan-Cancer Survival Analysis Web Tool The cover art, illustrating the work of Guo et al. (article e00069), presents a cherry blossom tree as a metaphor for data-driven precision oncology. The divided background contrasts favorable prognos...