Evolution of H5N1 Cross-Species Transmission: Adaptive Mutations Driving Avian-to-Human Infection [0.03%]
H5N1跨种间传播的进化：驱动禽流感传人的适应性突变
Wenxin Man,Lin Du,Ying Liu et al.
Wenxin Man et al.
First detected in poultry in China in 1996, the H5N1 avian influenza virus has evolved into a significant global public health hazard, primarily owing to its high pathogenicity and potential for interspecies transmission. While primarily af...
Metabolomic Signatures of Prediabetes in Mexican Americans: The Role of Genetics and Macronutrients [0.03%]
墨西哥美国人大规模代谢组学研究中空腹血糖受损者的遗传和膳食因素分析
Shinhye Chung,Charles Evans,Charles F Burant et al.
Shinhye Chung et al.
Prediabetes is one of the main health concerns in public health, and various etiological factors contribute to its onset. This study aimed to evaluate genetic associations and gene-macronutrient interaction with prediabetes-related metaboli...
From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes [0.03%]
从基因组化石到功能元件：假基因的演变故事
Mengyao Sun,Yanni Ma,Jia Yu
Mengyao Sun
Pseudogenes, as important products of genomic evolution, play unique regulatory roles in species adaptation. This review systematically summarizes the major types, functions, and regulatory mechanisms of metazoans pseudogenes, with a partic...
Zhiwu Dan,Yunping Chen,Wenchao Huang
Zhiwu Dan
Heterosis, the universal phenomenon in which F1 hybrids exhibit superior performance compared to their parental lines, is widely exploited in modern agriculture for improving crop yield, yet its genetic mechanisms remain incompletely unders...
Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy [0.03%]
DNA损伤修复的细胞放射增敏及优化放疗诱导的旁观者效应的分子机制研究
Anqi Lin,Jinyue He,Aimin Jiang et al.
Anqi Lin et al.
The DNA Damage Repair (DDR) signaling pathway serves as a crucial molecular hub that regulates chemotherapy efficacy, offering significant translational value in the field of precision oncology. This review systematically analyzes the molec...
Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing [0.03%]
基于直接RNA纳米孔测序的RNA修饰检测研究进展
Yaran Liu,Yang Li,Qiang Sun
Yaran Liu
RNA modifications add a dynamic and versatile regulatory layer to gene expression, influencing RNA stability, splicing, translation, and cellular responses. Despite their importance, traditional detection methods-such as antibody-based enri...
The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges (Advanced Genetics 4/06) [0.03%]
健康与疾病下的人类呼吸道病毒组：相互作用、失调及方法论挑战(高级遗传学4/06)
Xiaoxuan Yao,Xiaohui Zou,Bin Cao
Xiaoxuan Yao
The Dual Landscape of the Respiratory Virome The bronchial tree is the lung's forest, hosting a complex microbial world. This cover art captures the delicate balance of the respiratory virome. On one side, lush foliage signifies a diverse, ...
The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges [0.03%]
健康与疾病状态下的呼吸道病毒组：互作、失调与技术挑战
Xiaoxuan Yao,Xiaohui Zou,Bin Cao
Xiaoxuan Yao
The human respiratory virome is an underexplored component of the microbiome that includes diverse DNA and RNA viruses such as eukaryotic viruses, bacteriophages, and archaeal viruses. Recent advances in metagenomics have revealed the compl...
Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single-Cell Transcriptomics [0.03%]
通过孟德尔随机化和单细胞转录组学鉴定猫硫醚H和代谢特征作为潜在的肺癌生物标志物
Chenghu Song,Weici Liu,Zhao He et al.
Chenghu Song et al.
Lung cancer is a major global malignancy with debated roles for cathepsin H (CTSH), a lysosomal protease, and underexplored regulation by metabolites. We analyzed lung cancer incidence and hyperglycemia-related mortality trends (1990-2021) ...
Rare Structural Variants Uncovered by Optical Genome Mapping in Multisystem Inflammatory Syndrome in Children (MIS-C) [0.03%]
儿童多系统炎症综合征(MIS-C)中超罕见结构变异的光学基因组测序检测结果分析
Catherine A Brownstein,Caspar I van der Made,Kristin Cabral et al.
Catherine A Brownstein et al.
Multisystem inflammatory syndrome in children (MIS-C) is a pediatric complication of SARS-CoV-2 infection characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. In a single-center prospective cohort study, op...