Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication in vitro [0.03%]
尼克柳霉素的脂质纳米颗粒制剂（纳米NCM）能有效抑制体外SARS-CoV-2的复制
Guankui Wang,Hanmant Gaikwad,Mary K McCarthy et al.
Guankui Wang et al.
As exemplified by the COVID-19 pandemic, highly infective respiratory viruses can spread rapidly in the population because of lack of effective approaches to control viral replication and spread. Niclosamide (NCM) is an old anthelminthic dr...
SPECIFIC MOLECULAR RECOGNITION AS A STRATEGY TO DELINEATE TUMOR MARGIN USING TOPICALLY APPLIED FLUORESCENCE EMBEDDED NANOPARTICLES [0.03%]
基于 topical 应用的载荧光嵌体纳米颗粒的肿瘤特异性分子识别及其在术中精准切除的应用研究
Shawn Barton,Bo Li,Michael Siuta et al.
Shawn Barton et al.
The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging pr...
Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury [0.03%]
靶向NF-κB的纳米药物可缓解关节损伤后的急性疼痛
Huimin Yan,Xin Duan,Kelsey H Collins et al.
Huimin Yan et al.
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and...
Cellular Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging and Super-resolution Microscopy [0.03%]
利用荧光寿命成像和超分辨率显微镜研究Sn-2磷脂酰胆碱前药的细胞转运
Dolonchampa Maji,Jin Lu,Pinaki Sarder et al.
Dolonchampa Maji et al.
While the in vivo efficacy of Sn-2 phosphatidylcholine prodrugs incorporated into targeted, non-pegylated lipid-encapsulated nanoparticles was demonstrated in prior preclinical studies, the microscopic details of cell prodrug internalizatio...
Nanoparticle-Encapsulated Doxorubicin Demonstrates Superior Tumor Cell Kill in Triple Negative Breast Cancer Subtypes Intrinsically Resistant to Doxorubicin [0.03%]
纳米颗粒封装的多柔比星可有效杀死三阴性乳腺癌亚型肿瘤细胞且其对后者的固有抗药性较低
Aimee E Krausz,Brandon L Adler,Joy Makdisi et al.
Aimee E Krausz et al.
The effect of size and release kinetics of doxorubicin-nanoparticles on anti-tumor efficacy was evaluated in a panel of human cancer cell lines, including triple-negative breast cancer (TNBC) cells that frequently demonstrate resistance to ...