MiR-335-5p Escaped from CircKIAA0586 Adsorption Contributes to Mechanical Overloading-Induced Cartilage Degeneration by Targeting Lymphoid-Specific Helicase [0.03%]
circKIAA0586吸附的miR-335-5p逃逸通过靶向淋巴特异性解旋酶参与机械过载诱导的软骨退行性变
Haoyu Xie,Yuheng Lu,Jianying Pan et al.
Haoyu Xie et al.
Mechanical overload is a critical contributor to cartilage degeneration in osteoarthritis (OA) pathogenesis. Circular RNA (circRNA) is expected to provide a long-lasting therapy for OA. However, the involvement of the circRNA-associated com...
Isobutyrate Confers Resistance to Inflammatory Bowel Disease through Host-Microbiota Interactions in Pigs [0.03%]
异丁酸通过猪的宿主-微生物群相互作用赋予对炎症性肠病的抵抗力
Xiuyu Fang,Haiyang Liu,Junling Liu et al.
Xiuyu Fang et al.
Supplementation with short-chain fatty acids (SCFAs) is a potential therapeutic approach for inflammatory bowel disease (IBD). However, the therapeutic effects and mechanisms of action of isobutyrate in IBD remain unclear. Clinical data ind...
The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson's Disease [0.03%]
帕金森病发病部位发现噬菌体及其意义
Yun Zhao,Changxian Xiong,Bingwei Wang et al.
Yun Zhao et al.
Background: A century ago, a mystery between a virus and Parkinson's disease (PD) was described. Owing to the limitation of human brain biopsy and the challenge of electron microscopy in observing virions in human brain tissue, it has been ...
Perfusion Parameter Map Generation from 3 Phases of Computed Tomography Perfusion in Stroke Using Generative Adversarial Networks [0.03%]
基于生成对抗网络的卒中CT灌注参数图生成研究
Cuidie Zeng,Xiaoling Wu,Fusheng Ouyang et al.
Cuidie Zeng et al.
Computed tomography perfusion (CTP) plays a crucial role in guiding reperfusion therapy and patient selection for acute ischemic stroke (AIS) through perfusion parameter maps of the brain; however, its widespread use is limited by the compl...
Marine N-3 Fatty Acids Mitigate Hyperglycemia in Prediabetes by Improving Muscular Glucose Transporter 4 Translocation and Glucose Homeostasis [0.03%]
海洋N-3脂肪酸通过改善肌肉葡萄糖转运蛋白4易位和血糖稳态来缓解糖尿病前期的高血糖症状
Haoyu Li,Pan Zhuang,Xiaohui Liu et al.
Haoyu Li et al.
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been proposed to benefit cardiometabolic health. However, the relationship between the intake of DHA and EPA and type 2 diabetes (T2D) risk remains equivocal, and the effects o...
Erratum to "Aggravated Ulcerative Colitis via circNlgn-Mediated Suppression of Nuclear Actin Polymerization" [0.03%]
"circNlgn介导的核内肌动蛋白聚合抑制加重溃疡性结肠炎"一文的勘误通告
William W Du,Chi Zhou,Hui Yang et al.
William W Du et al.
[This corrects the article DOI: 10.34133/research.0441.]. Copyright © 2025 William W. Du et al.
Published Erratum
Research (Washington, D.C.). 2025 Apr 29:8:0684. DOI:10.34133/research.0684 2025
Leiming Xie,Jinbo Liu,Zhen Yang et al.
Leiming Xie et al.
Microrobotic swarms hold great promise for the revolution of cancer treatment. The coordination of miniaturized microrobots offers a unique approach to treating cancers at the cellular level with enhanced delivery efficiency and environment...
Discovery of a Novel Selective PAK1/HDAC6/HDAC10 Inhibitor ZMF-25 that Induces Mitochondrial Metabolic Breakdown and Autophagy-Related Cell Death in Triple-Negative Breast Cancer [0.03%]
发现选择性PAK1/HDAC6/HDAC10抑制剂ZMF-25可诱导三阴性乳腺癌细胞线粒体代谢紊乱及自噬相关性细胞死亡
Jin Zhang,Xiaoling Cheng,Gang Chen et al.
Jin Zhang et al.
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and addressing its intrinsic heterogeneity has emerged as a valuable avenue for novel clinical treatment strategy. Here, we put forward an innovative strateg...
Alanine Derived from Ruminococcus_E bovis Alleviates Energy Metabolic Disorders during the Peripartum Period by Providing Glucogenic Precursors [0.03%]
产丁酸肠球菌来源的丙氨酸通过提供生糖前体缓解围产期能量代谢紊乱
Fanlin Kong,Shuo Wang,Yijia Zhang et al.
Fanlin Kong et al.
Peripartum dairy cows commonly experience energy metabolism disorders, which lead to passive culling of postpartum cows and a decrease in milk quality. By using ketosis peripartum dairy cows as a model, this study aims to elucidate the meta...
Low-Intensity Pulsed Ultrasound Promotes Oligodendrocyte Maturation and Remyelination by Down-regulating the Interleukin-17A/Notch1 Signaling Pathway in Mice with Ischemic Stroke [0.03%]
低强度脉冲超声通过下调白细胞介素-17A/诺特定点信号通路促进缺血性卒鼠少突胶质细胞成熟和脱髓鞘组织的再髓化修复
Jingjing Wang,Yuxiao Gao,Bin Wang et al.
Jingjing Wang et al.
Increasing evidence indicates that oligodendrocyte (OL) numbers and myelin as a dynamic cellular compartment perform a key role in the maintenance of neuronal function. Inhibiting white matter (WM) demyelination or promoting remyelination h...