Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis [0.03%]
trabecular-like支架通过CAV1-HIF-1α轴介导的流体剪切应力诱导的代谢重编程调控成骨的作用
Wang Gong,Jing Zhang,Xinyun Liu et al.
Wang Gong et al.
The structural design of bone scaffolds determines the local fluid mechanical microenvironment; however, how such cues program stem cell metabolism to drive osteogenesis remains unclear. In this study, Voronoi-based trabecular-like scaffold...
EpiMII: Structure-Aware Graph Neural Networks for MHC-II Epitope Generation [0.03%]
基于结构的图神经网络用于MHC-II表位生成
Jiayi Yuan,Xiaowei Xu,Ze-Yu Sun et al.
Jiayi Yuan et al.
Major histocompatibility complex class II (MHC-II) neoantigens play a critical role in immunotherapy, either as direct effectors or through their influence on CD8+ T cells. However, only a small fraction of tumor DNA mutations qualify as fu...
Switchable Ultralong Chiral Signal Transmission and Gate Tunability in Organic Chiral Semiconductor [0.03%]
手性有机半导体中的超长距离手性信号传输及 gate 调控作用
Renjie Hu,Xiaoying Niu,Xiangqian Lu et al.
Renjie Hu et al.
Chiral structures have substantial potential for spin information utilization because of their distinctive spatial symmetry-breaking features and the consequent strong spin-charge correlation. One of the limitations in the development of ch...
Rejuvenated Hematopoietic Stem and Progenitor Cell-Engineered CAR-Armored Natural Killer T Cells for Malignant Pleural Mesothelioma [0.03%]
用于恶性胸膜间皮瘤的年轻化造血干细胞和工程CAR装甲自然杀伤T细胞
Yan-Ruide Li,Yichen Zhu,Zhe Li et al.
Yan-Ruide Li et al.
Malignant pleural mesothelioma (MPM) is a rare and highly aggressive malignancy arising from the pleural lining, characterized by a dismal prognosis and limited therapeutic options. Mesothelin (MSLN)-directed chimeric antigen receptor (CAR)...
DNA Nanotechnology-Enabled Precise Regulation of Nanozymes and Their Applications [0.03%]
基于DNA纳米技术的纳米酶活性精准调控及其应用研究进展
Zishuo Liu,Yuanbo Zhao,Haoxiang Chen et al.
Zishuo Liu et al.
Nanozymes overcome key limitations of natural enzymes, including poor environmental tolerance, high production costs, and batch-to-batch variability, with their enhanced physicochemical stability and controllable catalytic performance, thus...
Chimeric Antigen Receptor T Cells as Living Therapeutics Targeting Senescence and Age-Related Diseases [0.03%]
嵌合抗原受体T细胞作为针对衰老和与年龄有关的疾病的活疗法
Qingyi Shao,Danlei Chen,Wenxia Shao et al.
Qingyi Shao et al.
The aging of the global population exacerbates the burden of age-related diseases; however, therapies that can intervene in fundamental aging processes are lacking. Senescent cells drive chronic inflammation and multitissue dysfunction thro...
Ag-CuO Nanozymes Superior to Commercial Silver-Based Dressings: Synergistic Antibacterial Therapy via PTS-Mediated Starvation and Cuproptosis-Like Death [0.03%]
优于市售银制敷料的Ag-CuO纳米酶：通过PTS介导的饥饿和类似铜死亡的协同抗菌疗法
Shuo Zhang,Dongliang Yang,Yunfeng Zheng et al.
Shuo Zhang et al.
Burn wounds are prone to infection, and traditional antibiotics cannot be used locally due to bacterial resistance. As a clinical first-line use of silver ion dressings, their use is often limited due to potential toxic side effects and hig...
Experimentally Validated Quantum-Secure Federated Learning over a Multi-user Quantum Network [0.03%]
实验验证的量子安全多方用户量子网络联邦学习
Zhi-Ping Liu,Xiao-Yu Cao,Hao-Wen Liu et al.
Zhi-Ping Liu et al.
Federated learning enables decentralized, privacy-preserving training but remains vulnerable to privacy leakage in the quantum era. Quantum federated learning (QFL) offers a promising path toward enhanced security and efficiency. However, a...
Natural Flavonoids Genistein and Baicalein as Well-Tolerated Radiosensitizers to Enhance the Efficacy of 177Lu-PSMA617 in Prostate Cancer: In Vitro and In Vivo Studies [0.03%]
天然类黄酮染料木黄酮和黄芩素作为耐受性良好的放射增敏剂，可增强177 Lu-PSMA617在前列腺癌中的疗效：体内外研究
Congjie He,Yuting Shao,Ying Bao et al.
Congjie He et al.
The efficacy of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy in metastatic castration-resistant prostate cancer is limited by tumor heterogeneity and intrinsic radioresistance. This study investigates 2 natural fla...
A Low-Profile Self-Stealth Programmable Metasurface with In-Band and Out-of-Band RCS Reduction [0.03%]
一种具有带内和带外RCS减缩的低剖面自适应可编程超表面
Yajie Mu,Jiaqi Han,Lihao Zhu et al.
Yajie Mu et al.
Programmable metasurfaces show great application potential in many fields, so studying their radar cross-section reduction (RCSR) characteristics is very important. Metasurfaces based on polarization conversion and artificial magnetic condu...