Molecular Thermal Motion Modulated Room-Temperature Phosphorescence for Multilevel Encryption [0.03%]
分子热运动调节的室温磷光多级加密信息存储材料
Jiaqiang Zhao,Guojuan Yan,Wei Wang et al.
Jiaqiang Zhao et al.
The stimulus-responsive room-temperature phosphorescence (RTP) materials have become an increasingly significant topic in the fields of bioimaging, sensing, and anticounterfeiting. However, this kind of materials is scarce to date, especial...
Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death [0.03%]
半胱天冬酶-1和Gasdermin D在NLRP1b炎性小体诱导的细胞死亡中为具有不同调控策略的理想靶点
Xiang Li,Peipei Zhang,Zhiyong Yin et al.
Xiang Li et al.
Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-...
Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept [0.03%]
基于分布与代谢的药物发现：一种钾离子竞争性酸阻滞剂的概念验证研究
Ming-Shu Wang,Yi Gong,Lin-Sheng Zhuo et al.
Ming-Shu Wang et al.
Conventional methods of drug design require compromise in the form of side effects to achieve sufficient efficacy because targeting drugs to specific organs remains challenging. Thus, new strategies to design organ-specific drugs that induc...
Xiaoxuan Zhang,Guopu Chen,Lijun Cai et al.
Xiaoxuan Zhang et al.
Micromotors have demonstrated values in drug delivery, and recent attempts focus on developing effective approaches to generate functional micromotors to improve this area. Here, with the integration of microfluidic droplet printing and wet...
Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network [0.03%]
基于结构的深度图神经网络蛋白质可共价修饰半胱氨酸位点的映射与预测
Hongyan Du,Dejun Jiang,Junbo Gao et al.
Hongyan Du et al.
Covalent ligands have attracted increasing attention due to their unique advantages, such as long residence time, high selectivity, and strong binding affinity. They also show promise for targets where previous efforts to identify noncovale...
Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice [0.03%]
使用病毒受体结合域给药的小鼠模型评估SARS-CoV-2中和纳米抗体
Song Liu,Guanghui Li,Lei Ding et al.
Song Liu et al.
Due to the rapid spread of coronavirus disease 2019 (COVID-19), there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease. The isolated nanobody Nb11-59 binds to the severe acute r...
Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson's Disease [0.03%]
超小配位聚合物用于缓解ROS介导的炎症并实现帕金森病神经保护
Guowang Cheng,Xueliang Liu,Yujing Liu et al.
Guowang Cheng et al.
Parkinson's disease (PD) is the second most common neurodegenerative disease globally, and there is currently no effective treatment for this condition. Excessive accumulation of reactive oxygen species (ROS) and neuroinflammation are major...
Letao Yang,Lin Y Hung,Yuefei Zhu et al.
Letao Yang et al.
Tremendous progress has been made in the past decade regarding our understanding of the gut microbiome's role in human health. Currently, however, a comprehensive and focused review marrying the two distinct fields of gut microbiome and mat...
Reconfigurable Mechanochromic Patterns into Chameleon-Inspired Photonic Papers [0.03%]
变色龙启发的光子纸中的可重构机械发光图案化技术
Dongpeng Yang,Yang Hu,Dekun Ma et al.
Dongpeng Yang et al.
Photonic crystal (PC) patterns have shown wide applications in optical devices, information encryption, anticounterfeiting, etc. Unfortunately, it is still a great challenge to reconfigure the PC patterns once fabricated. Herein, a new stra...
Helper T Cell (CD4+) Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity [0.03%]
靶向辅助T细胞（CD4+）的他克莫司输送精准调控同种异体体液免疫响应
Jia Shen,Chang Liu,Pengpeng Yan et al.
Jia Shen et al.
Antibody-mediated rejection (ABMR) is a major cause of dysfunction and loss of transplanted kidney. The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells. However, the prognosis of patient...