Host-Defense-Peptide-Mimicking β-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously [0.03%]
一种干扰群体感应并同时杀死单个细菌的宿主防御肽模拟β肽聚合物的双模抗菌剂作用机制研究
Wanlin Li,Ximian Xiao,Yuchen Qi et al.
Wanlin Li et al.
Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but their clinical applications are limited by proteolytic instability, high-cost, and comp...
Natural Morin-Based Metal Organic Framework Nanoenzymes Modulate Articular Cavity Microenvironment to Alleviate Osteoarthritis [0.03%]
基于天然莫尔宁的金属有机框架纳米酶调节关节腔微环境以缓解骨关节炎
Jinhong Cai,Lian-Feng Liu,Zainen Qin et al.
Jinhong Cai et al.
Osteoarthritis (OA) is always characterized as excessive reactive oxygen species (ROS) inside articular cavity. Mimicking natural metalloenzymes with metal ions as the active centers, stable metal organic framework (MOF) formed by natural p...
Zhihan Lv
Zhihan Lv
This work aims to explore the impact of Digital Twins Technology on industrial manufacturing in the context of Industry 5.0. A computer is used to search the Web of Science database to summarize the Digital Twins in Industry 5.0. First, the...
Rational Design of Biological Crystals with Enhanced Physical Properties by Hydrogen Bonding Interactions [0.03%]
氢键作用力增强物理性质的生物晶体理性设计
Hui Yuan,Bin Xue,Dingyi Yang et al.
Hui Yuan et al.
Hydrogen bonds are non-covalent interactions and essential for assembling supermolecules into ordered structures in biological systems, endowing crystals with fascinating physical properties, and inspiring the construction of eco-friendly e...
Metal-Phenolic Network-Facilitated "Foe-to-Friend" Conversion of Melittin for Cancer Immunotherapy with Boosted Abscopal Effect [0.03%]
金属-酚类网络介导的蜂毒素抗癌免疫治疗中的“敌”变“友”转化及远处效应增强作用
Yuxin Guo,Xinping Zhang,Shao-Zhe Wang et al.
Yuxin Guo et al.
As a naturally occurring cytolytic peptide, melittin (Mel) has strong cytolytic activity and is a potent therapeutic peptide for cancer therapy. However, the serious hemolytic activity of Mel largely impedes its clinical applications. In th...
Trends and Potential of Machine Learning and Deep Learning in Drug Study at Single-Cell Level [0.03%]
单细胞水平药物研究中的机器学习与深度学习的发展趋势及潜在价值
Ren Qi,Quan Zou
Ren Qi
Cancer treatments always face challenging problems, particularly drug resistance due to tumor cell heterogeneity. The existing datasets include the relationship between gene expression and drug sensitivities; however, the majority are based...
Neural Network Accelerated Investigation of the Dynamic Structure-Performance Relations of Electrochemical CO2 Reduction over SnO x Surfaces [0.03%]
基于SnO x 表面电化学CO2还原的结构性能动态关联性的神经网络加速研究
Lulu Li,Zhi-Jian Zhao,Gong Zhang et al.
Lulu Li et al.
Heterogeneous catalysts, especially metal oxides, play a curial role in improving energy conversion efficiency and production of valuable chemicals. However, the surface structure at the atomic level and the nature of active sites are still...
SARS-CoV-2 Spike Protein Post-Translational Modification Landscape and Its Impact on Protein Structure and Function via Computational Prediction [0.03%]
基于计算预测的SARS-CoV-2刺突蛋白翻译后修饰图谱及其对蛋白质结构和功能的影响
Buwen Liang,Yiying Zhu,Wenhao Shi et al.
Buwen Liang et al.
To elucidate the role of post-translational modifications (PTMs) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein's structure and virulence, we generated a high-resolution map of 87 PTMs using liquid chromatogra...
Nanostructured Conductive Polypyrrole for Antibacterial Components in Flexible Wearable Devices [0.03%]
用于柔性可穿戴设备的纳米结构导电聚吡咯抗菌成分
Yuzheng Wu,Dezhi Xiao,Pei Liu et al.
Yuzheng Wu et al.
The power generated by flexible wearable devices (FWDs) is normally insufficient to eradicate bacteria, and many conventional antibacterial strategies are also not suitable for flexible and wearable applications because of the strict mechan...
One-Pot Protolignin Extraction by Targeted Unlocking Lignin-Carbohydrate Esters via Nucleophilic Addition-Elimination Strategy [0.03%]
通过亲核加成-消除策略靶向解锁木聚糖中酯键的一锅法提取原生木质素
Yuhan Lou,Xinyue Sun,Yanyan Yu et al.
Yuhan Lou et al.
Protolignin extraction can facilitate structure elucidation and valorization of lignin in biorefinery, but is rather challenging due to the complex chemical bonds present. Here, we developed the in situ generated NH3-reline (IGNR) system to...