Cellulose-Based Ultralong Room-Temperature Phosphorescence Nanomaterials with Tunable Color and High Quantum Yield via Nano-Surface Confining Effect [0.03%]
基于纳米表面限制效应的可调色高性能纤维素室温磷光纳米材料
Xin Zhang,Chunchun Yin,Jingxuan You et al.
Xin Zhang et al.
How to achieve multicolor organic room-temperature phosphorescence (RTP) is still challenging and striking. Herein, we discovered a new principle to construct eco-friendly color-tunable RTP nanomaterials based on the nano-surface confining ...
Comprehensive Metabolic Profiling and Genome-wide Analysis Reveal Therapeutic Modalities for Hepatocellular Carcinoma [0.03%]
全面的代谢谱分析和全基因组分析揭示了肝细胞癌的治疗模式
Feng Qi,Jia Li,Zhuoran Qi et al.
Feng Qi et al.
Understanding the details of metabolic reprogramming in hepatocellular carcinoma (HCC) is critical to improve stratification for therapy. Both multiomics analysis and cross-cohort validation were performed to investigate the metabolic dysre...
Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility [0.03%]
微管通过调节细胞核力学和染色质可及性促进肌动蛋白-myosin组装
Jiwen Geng,Zhefeng Kang,Qian Sun et al.
Jiwen Geng et al.
Cellular behaviors and functions can be regulated by mechanical cues from microenvironments, which are transmitted to nucleus through the physical connections of cytoskeletons in the cells. How these physical connections determine transcrip...
Single-Exosome Profiling Identifies ITGB3+ and ITGAM+ Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer [0.03%]
单个外泌体分析鉴定出ITGB3+和ITGAM+亚群作为结直肠癌早期诊断生物标志物和治疗靶点的潜力
Wei Guo,Yanling Cai,Xianming Liu et al.
Wei Guo et al.
Tumor metastasis is a hallmark of colorectal cancer (CRC), in which exosome plays a crucial role with its function in intercellular communication. Plasma exosomes were collected from healthy control (HC) donors, localized primary CRC and li...
Solving Strength-Toughness Dilemma in Superhard Transition-Metal Diborides via a Distinct Chemically Tuned Solid Solution Approach [0.03%]
通过独特的化学调节固溶体方法解决超硬过渡金属二硼化物的强度-韧性难题
Xinlei Gu,Chang Liu,Xinxin Gao et al.
Xinlei Gu et al.
Solid solution strengthening enhances hardness of metals by introducing solute atoms to create local distortions in base crystal lattice, which impedes dislocation motion and plastic deformation, leading to increased strength but reduced du...
Mass Spectrometry Imaging-Based Single-Cell Lipidomics Profiles Metabolic Signatures of Heart Failure [0.03%]
基于质谱成像的单细胞脂质组学描绘心力衰竭的代谢标志物
Jie Ren,Hao-Wen Li,Liang Chen et al.
Jie Ren et al.
Heart failure (HF), leading as one of the main causes of mortality, has become a serious public health issue with high prevalence around the world. Single cardiomyocyte (CM) metabolomics promises to revolutionize the understanding of HF pat...
3D-Printed Janus Piezoelectric Patches for Sonodynamic Bacteria Elimination and Wound Healing [0.03%]
用于声动力杀菌和伤口愈合的3D打印Janus压电贴片
Danqing Huang,Yi Cheng,Guopu Chen et al.
Danqing Huang et al.
Management of infected wounds has raised worldwide concerns. Attempts in this field focus on the development of intelligent patches for improving the wound healing. Here, inspired by the cocktail treatment and combinational therapy stratage...
Combined Photoredox Catalysis for Value-Added Conversion of Contaminants at Spatially Separated Dual Active Sites [0.03%]
空间分离双活性位点联合光红氧化催化的高附加值转化污染物反应
Jieyuan Li,Ruimin Chen,Kaiwen Wang et al.
Jieyuan Li et al.
As 2 indispensable counterparts in one catalysis system, the independent reduction and oxidation reactions require synergetic regulation for cooperatively promoting redox efficiency. Despite the current success in promoting the catalytic ef...
Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease [0.03%]
通过脑膜淋巴管途径输送仿生脂质体用于帕金森病的靶向治疗
Jing Liu,Duyang Gao,Dehong Hu et al.
Jing Liu et al.
Targeted therapy of Parkinson's disease is an important challenge because of the blood-brain barrier limitation. Here, we propose a natural killer cell membrane biomimetic nanocomplex (named BLIPO-CUR) delivered via the meningeal lymphatic ...
Site-Selective Polyolefin Hydrogenolysis on Atomic Ru for Methanation Suppression and Liquid Fuel Production [0.03%]
位点选择性聚烯烃氢解Ru催化剂用于甲烷化抑制和液体燃料生产
Mingyu Chu,Xianpeng Wang,Xuchun Wang et al.
Mingyu Chu et al.
Catalytic hydrogenolysis of end-of-life polyolefins can produce value-added liquid fuels and therefore holds great promises in plastic waste reuse and environmental remediation. The major challenge limiting the recycling economic benefit is...