Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation [0.03%]
乳酸诱导线粒体钙摄取3通过促进中性粒细胞胞外陷阱形成加重心肌缺血再灌注损伤
Hongru Zhang,Lei Liu,Chuchu Shen et al.
Hongru Zhang et al.
Background: Ischemic heart disease is a leading cause of mortality and disability worldwide among cardiovascular conditions. Myocardial ischemia-reperfusion injury (MIRI) occurs following percutaneous coronary intervention, during which neu...
Ab Initio Lattice Quantum Chromodynamics Calculations of Parton Physics in the Proton: Large-Momentum Effective Theory versus Short-Distance Expansion [0.03%]
从头算晶格量子色动力学中的部分子物理计算：大动量有效理论与短距离展开式
Xiangdong Ji
Xiangdong Ji
Although equivalent in the infinite-momentum limit, large-momentum effective theory (LaMET) and short-distance operator product expansion (SDE) are 2 very different approaches to obtain parton distribution functions (PDFs) from coordinate-s...
Nitrite Reductases in Biomedicine: From Natural Enzymes to Artificial Mimics [0.03%]
生物医学中的亚硝酸盐还原酶：从天然酶到人工模拟物
Sai Zhu,Zhengbiao Liu,Bo Hu et al.
Sai Zhu et al.
Nitrite reductases (NiRs) are natural enzymes that facilitate the reduction of nitrite. They are essential for the microbial nitrogen cycle and play a vital role in regulating numerous physiological and pathological processes associated wit...
A Domain-Specific Pretrained Model for Detecting Malignant and Premalignant Ocular Surface Tumors: A Multicenter Model Development and Evaluation Study [0.03%]
针对眼部表面肿瘤恶性及癌前病变的专用预训练模型检测多中心模型开发与评估研究
Zhongwen Li,Yangyang Wang,Wei Qiang et al.
Zhongwen Li et al.
Malignant and premalignant ocular surface tumors (OSTs) can be sight-threatening or even life-threatening if not diagnosed and treated promptly. Artificial intelligence holds great promise for the early detection of these diseases. However,...
Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression [0.03%]
靶向作用于外显子环状OGT RNA/O-GlcNAc转移酶/叉头盒C1轴可抑制神经母细胞瘤进程中天冬酰胺和甘氨酸介导的铁死亡受抑现象
Qilan Li,Yang Cheng,Chunhui Yang et al.
Qilan Li et al.
The disruption of ferroptosis, an emerging form of programmed cell death, is crucial in the development and aggressiveness of tumors. Meanwhile, the mechanisms and treatments that control ferroptosis in neuroblastoma (NB), a prevalent extra...
Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging [0.03%]
溶菌酶通过调节肠道微生物群成为血管炎症衰老的关键调节因子
Chenyang Zhang,Xin Zhao,Hang Zhang et al.
Chenyang Zhang et al.
Vascular inflammatory aging is strongly associated with multimorbidity, including immunosenescence. Here, bioinformatic analysis indicated elevated expression of the lysozyme (LYZ) gene in age-dependent vascular diseases. Lyz1 deficiency le...
Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma [0.03%]
Sprouty 4棕榈酰化的双重调控：ZDHHC7和棕榈酰蛋白硫酯酶1在顺铂耐药性骨肉瘤治疗中的潜在策略
Tianlong Huang,Yifan Chen,Qiangqiang Zhao et al.
Tianlong Huang et al.
Background: Osteosarcoma (OS) is a primary malignant bone tumor predominantly affecting adolescents. Chemotherapeutic agents, such as cisplatin, are commonly used in OS treatment; however, drug resistance markedly undermines treatment effic...
Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction [0.03%]
磁驱动再生医学的力量：骨组织再生与功能重建
Chenxi Xu,Pengzhen Cheng,Junxiang Wang et al.
Chenxi Xu et al.
To improve the treatment outcomes for large bone defects and osteoporosis, researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation, biomaterial intervention, and biophysical stim...
Defective Endothelial Glutaminolysis Contributes to Impaired Angiogenesis and Poor Ischemic Tissue Repair in Diabetes [0.03%]
糖尿病患者的血管内皮谷氨酰胺代谢缺陷与缺血组织修复不良和血管生成障碍有关
Meina Zhao,Jiaheng Zhou,Yang Hu et al.
Meina Zhao et al.
It has been demonstrated that glutamine is a key player in boosting endothelial cell (EC) proliferation. However, despite its importance, the role of endothelial glutaminolysis in diabetes remains largely unexplored. Our research aimed to i...
Revolutionizing Autoimmune Kidney Disease Treatment with Chimeric Antigen Receptor-T Cell Therapy [0.03%]
CAR-T细胞疗法革新自身免疫性肾脏病治疗方式
Rui Gu,Jiayi Shen,Jiayu Zhang et al.
Rui Gu et al.
Autoimmune kidney diseases (AIKDs) depict a range of disorders involving immune-mediated damage to the kidneys, where conventional biologic therapies involving monoclonal antibodies often prove insufficient because of persistent autoreactiv...