Lin Chen,Zhou-Xian Pan,Zi-Qi Ma et al.
Lin Chen et al.
The understanding of type 2 inflammatory diseases is undergoing a paradigm shift from "immune imbalance" toward "immune-metabolic crosstalk". Energy metabolism not only fuels immune responses but also fundamentally dictates the functional p...
AI-Powered Discovery of Rosmarinic Acid as a Novel Ferroptosis Inhibitor for Ulcerative Colitis via Targeting the ALOX15-VDAC1 Axis [0.03%]
基于人工智能发现石松内酯通过靶向ALOX15-VDAC1轴抑制类风湿关节炎铁死亡作用机制研究
Guixuan Fang,Jingli Ao,Xiao Li et al.
Guixuan Fang et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited mechanism-based therapies, and ferroptosis-an iron-dependent lipid peroxidation-driven cell death-has emerged as a critical pathogenic event. Using a machine learn...
Small-Molecule Boron-10-Enriched Carriers with Exceptional Aqueous Solubility for Enhanced Boron Neutron Capture Therapy of Malignant Tumors [0.03%]
一种用于恶性肿瘤增强型硼中子俘获治疗的小分子富集硼-10载带剂，具有优异的水溶性
Tongyin Xiong,Xiangdi Yang,Tingting Li et al.
Tongyin Xiong et al.
Boron neutron capture therapy (BNCT) enables localized tumor ablation while minimizing damage to surrounding tissues, offering advantages for treating anatomically challenging sites. However, current boron carriers, such as sodium borocapta...
Spatiotemporal Deep Video-Phenomapping Decodes Microvascular Rarefaction in Middle-Aged and Elder Renovascular Hypertension: A Multi-Modal Study Integrating Spatial Transcriptomics and Mitochondrial Pyroptosis [0.03%]
时空深度视频表型映射解码中老年肾血管性高血压微血管稀疏：空间转录组学和线粒体焦亡的多模态整合研究
Lingjie Ju,Ri Ji,Hong Meng et al.
Lingjie Ju et al.
In middle-aged and older atherosclerotic renal artery stenosis (ARAS), the anatomical severity of stenosis is a poor surrogate for microvascular competence, and the renal benefit of revascularization is unpredictable. We developed Renal-Vid...
Bioinspired Ruthenium Arene Complex with Pseudo-Vacant Coordination Sites as Efficient Small-Molecular Antioxidant Enzyme Mimics for Preventing Vascular Restenosis [0.03%]
模拟酶抗氧化剂防治血管内膜增生的类金属酶分子及其应用
Haojie Xu,Yichen Cai,Wei Geng et al.
Haojie Xu et al.
With the ongoing progress in coronary interventional therapy, the progression of atherosclerosis is no longer solely governed by its natural course. Postprocedural neointimal hyperplasia and plaque formation markedly increase the risk of ca...
Neural Regulation of Cardiac Arrhythmias: From the Brain-Heart Axis to Emerging Precision Therapies [0.03%]
心脏心律失常的神经调节：从脑心轴到新兴的精准治疗方法
Yudong Xia,Yu Han,Tao Yu et al.
Yudong Xia et al.
Historically, cardiac arrhythmias have been interpreted as intrinsic ion channel disorders of the cardiomyocyte. However, the field is currently undergoing a fundamental paradigm shift, recognizing the brain-heart axis as the ultimate arbit...
N6-Methyladenosine on Key Messenger RNAs Governs Reproductive Development and Metabolic Adaptation in Human Blood Fluke [0.03%]
钉螺关键信使RNA上的N6-甲基腺苷调控血吸虫的生殖发育及代谢适应性
Bikash Ranjan Giri,Zihao Zhang,Lu Liu et al.
Bikash Ranjan Giri et al.
Schistosomiasis, a neglected tropical disease, affects more than 250 million people worldwide. The pathology and transmission of schistosomiasis rely on the parasite's extended survival and massive egg output. While N6-methyladenosine (m6A)...
Additive-Free Contact-Electro-Catalysis/Vacuum Ultraviolet System for Rapid Mitigation of Antimicrobial-Resistance-Associated Contaminants in Water [0.03%]
一种无添加的接触电催化/真空紫外系统用于快速去除水中的抗菌药物抗性污染物
Weixin Li,Xinyu Xing,Kai Yang et al.
Weixin Li et al.
The widespread occurrence of antimicrobial-resistance-associated contaminants in natural and engineered water systems poses a major threat to environmental and public health. Conventional contact-electro-catalysis (CEC) can generate interfa...
Predicting 1-Year Renal Outcomes in Patients with Diabetic Kidney Disease in CKD Stages 3 to 4: A Multimodal Machine Learning Approach Fusing Clinical Composites and Pathology Images [0.03%]
融合临床综合指标和病理图像的多模态机器学习方法预测3至4期糖尿病肾病患者1年内的肾脏预后
Xiangmeng Li,Jinyu Liu,Erjina Huo et al.
Xiangmeng Li et al.
Patients with diabetic kidney disease (DKD) at chronic kidney disease (CKD) stages 3 to 4 are at high risk for rapid renal function decline within 1 year. However, owing to the multifactorial complexity of the disease, effective prognostic ...
Zhichao Deng,Ruofei Zhang,Yuanyuan Zhu et al.
Zhichao Deng et al.
Antioxidant nanozymes regulate reactive oxygen species homeostasis by mimicking the core catalytic functions of natural antioxidant enzymes, including superoxide dismutase-, catalase-, and glutathione peroxidase-like activities. The clinica...