Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3 [0.03%]
Piezo1介导的铁死亡通过激活转录因子3调控溶质载体成员7A11转录活性从而抑制小鼠衰老创面愈合
Chen Jin,Du-Piao Zhang,Zhen Lin et al.
Chen Jin et al.
Ferroptosis plays a role in wound healing during the maturation of senescent endothelial cells. This study explores the modulation of ferroptosis in senescent human umbilical vein endothelial cells (HUVECs) and wound-healing processes by Pi...
Emotional and Directional Enabled Programmable Flexible Haptic Interface for Enhanced Cognition in Disabled Community [0.03%]
用于残疾人群认知增强的可编程柔性触觉接口（情感和方向感知）
Yuhan Liu,Liuyang Han,Siqi Lv et al.
Yuhan Liu et al.
Advanced haptic feedback interfaces are essential for human-machine interaction, particularly in assistive technologies that offer versatile commands, simplify navigation, and enhance emotional interactions for individuals with visual and h...
Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment [0.03%]
自然杀伤细胞免疫检查点及其在癌症治疗中的靶向作用
Anqi Lin,Pengxi Ye,Zhengrui Li et al.
Anqi Lin et al.
Natural killer (NK) cells, serving as pivotal mediators of innate immunity, play an important role in antitumor immunity. Immune checkpoint can be expressed on the surface of NK cells and meticulously regulates their activation states and e...
Deciphering the Physical Binding Mechanism of Enzyme-Photosensitizer Facilitates Catalysis-Augmented Photodynamic Therapy [0.03%]
揭示酶-光敏剂物理结合机制可增强催化增效光动力治疗
Bingqing Jia,Yang Liu,Xudong Geng et al.
Bingqing Jia et al.
Enzyme-photosensitizer (PS) conjugates hold great promise for clinical treatment of cancer and infectious diseases via catalysis-augmented photodynamic therapy (PDT). Compared to covalent coupling, physical binding utilizing noncovalent int...
Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies [0.03%]
抗vinculin自身抗体揭示了自身免疫性podocytopathy的新机制
Hanyan Meng,Dongjie Wang,Chen Zheng et al.
Hanyan Meng et al.
Background: Emerging evidence suggests that autoantibodies targeting podocytes are potential contributors to idiopathic nephrotic syndrome (INS); however, the specific mechanisms remain unclear. This study aims to explore the pathogenic rol...
Magnetic Cell-Mimetic Droplet Microrobots with Division and Exocytosis Capabilities [0.03%]
具备分裂和胞吐能力的磁性类细胞微液滴机器人
Shimin Yu,Weiwei Zhang,Yongzhi Feng et al.
Shimin Yu et al.
The first challenge in building a living robotic system inspired by life evolution is how to replicate the original form of life-the cell. However, current microrobots mimic cell motion control but fail to replicate the functional biologica...
Carbon Emission Based Predictions of Anthropogenic Impacts on Groundwater Storage at Typical Basins in 2050 [0.03%]
基于碳排放的典型流域2050年人为影响下地下水储量预测
Ying Zhao,Jiabin Ma,Yuelei Li et al.
Ying Zhao et al.
Understanding the impacts of anthropogenic activities on groundwater is crucial for its management and utilization. However, predicting anthropogenic impacts on groundwater remains challenging due to their complexity. As any anthropogenic a...
Wenhui Jiang,Changhong Liu,Wei Liu et al.
Wenhui Jiang et al.
As a critical global public health concern, food safety has prompted substantial strategic advancements in detection technologies to safeguard human health. Integrated intelligent sensing systems, incorporating advanced information percepti...
Meta-transcriptomics Reveals Dysbiosis of the Respiratory Microbiome in Older Adults with Long COVID [0.03%]
元转录组学揭示了长期新冠老年患者呼吸道微生物群的失调现象
Meng&#x;en Liao,Jianpeng Cai,Feng Zhu et al.
Meng&#x;en Liao et al.
Limited research has investigated the connection between long COVID (LC) and the respiratory microbiome, particularly in older adults. This study aimed to characterize the respiratory microbiome of older LC patients (with an average age of ...
CX3CR1+ Monocytes/Macrophages Promote Regional Immune Injury in Mesangial Proliferative Glomerulonephritis through Crosstalk with Activated Mesangial Cells [0.03%]
趋化因子受体CX3CR1阳性单核/巨噬细胞通过与活化的系膜细胞相互作用促进增殖性系膜肾小球肾炎的局部免疫损伤
Jie Zhang,Qingyun Fang,Yiyu Huang et al.
Jie Zhang et al.
Mesangial proliferative glomerulonephritis (MsPGN) is the most common glomerulonephritis pathological type, including IgA nephropathy (IgAN), in which regional immune injury leads to disease progression without targeted treatment approaches...