Targeting ApoE-KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice [0.03%]
靶向ApoE-KCC2信号可救治小鼠的GABA能突触功能障碍和类似抑郁的行为
Chengyuan Xu,Jing Liu,Mengru Guo et al.
Chengyuan Xu et al.
Apolipoprotein E (ApoE) has been implicated in neurodegenerative diseases; however, its function and underlying mechanisms in depression remain elusive. In this study, we employed chronic social defeat stress (CSDS) to establish a mouse mod...
A Multifunctional Fe-EGCG@RSL3 Nanomedicine Synergizes Ferroptosis Induction and Tumor Microenvironment Remodeling for Enhanced Bladder Cancer Immunotherapy [0.03%]
具有多重功能的Fe-EGCG@RSL3纳米药物协同促进铁死亡诱导和肿瘤微环境重塑以增强膀胱癌免疫治疗
Chengjunyu Zhang,Sen Liu,Jianhui Zhang et al.
Chengjunyu Zhang et al.
Ferroptosis has promising potential for augmenting antitumor effects, but monotherapy with ferroptosis inducers in vivo has been reported to have limited efficacy in tumor management. The development of synergistic strategies with targeted ...
Immersion Phase Separation 3-Dimensional Printing for Strain-Stiffening Hydrogel Scaffolds [0.03%]
用于制备应变硬化的水凝胶支架的浸相分离三维打印技术
Muyuan Chai,Haolin Bu,Rui Zheng et al.
Muyuan Chai et al.
Strain-stiffening hydrogels, which mimic the nonlinear mechanical behavior of biological tissues such as skin, arteries, and cartilage, hold transformative potential for biomedical applications. This study introduces immersion phase separat...
Mechanisms Underlying the Impact of Interleukin Family on Acute Kidney Injury: Pathogenesis, Progression, and Therapy [0.03%]
细胞因子家族调控急性肾损伤的机制：发病机制、进展和治疗
Yuwei Ji,Zhenkai Zhao,Yan Yang et al.
Yuwei Ji et al.
Acute kidney injury (AKI) is a clinical syndrome with high mortality, and its pathogenesis involves complex inflammatory regulatory mechanisms. As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in the ...
Skeleton-Forming Responses of Reef-Building Corals under Ocean Acidification [0.03%]
珊瑚骨骼形成对海洋酸化的响应机制研究
Yixin Li,Hongwei Zhao,Yunpeng Zhao et al.
Yixin Li et al.
Ocean acidification is becoming more prevalent and may contribute to coral reef degradation, yet our understanding of its role in global reef decline remains limited. Therefore, there is an urgent need to study the impact of reduced pH leve...
Tingwen Xiang,Chuan Yang,Langlang Xie et al.
Tingwen Xiang et al.
Tryptophan (Trp), an essential amino acid, performs as a precursor for synthesizing various bioactive molecules primarily metabolized through the kynurenine (Kyn), serotonin, and indole pathways. The diverse metabolites were deeply implicat...
Structural Characteristics and Recent Advances in Thermoelectric Binary Indium Chalcogenides [0.03%]
二元铟硫属化合物热电材料的结构特征及最新进展
Yasong Wu,Binjie Zhou,Lu Liu et al.
Yasong Wu et al.
Thermoelectric (TE) materials have garnered widespread research interest owing to their capability for direct heat-to-electricity conversion. Binary indium-based chalcogenides (In-X, X = Te, Se, S) stand out in inorganic materials by virtue...
Nanoelectrochemical Monitoring of pH-Regulated Reactive Oxygen and Nitrogen Species Homeostasis in Macrophages Lysosomes during Phagocytosis [0.03%]
巨噬细胞溶酶体在吞噬作用过程中pH调节的活性氧和活性氮稳态的纳米电化学监测
Yu-Ting Qi,Rui-Xue Gao,Ying Chen et al.
Yu-Ting Qi et al.
Macrophages participate in the immune system by recognizing and engulfing foreign bodies inside phagosomes, which fuse with lysosomes in their cytoplasm to form mature phagolysosomes. Lysosomes have an acidic interior and generate and relea...
Velocity-Constraint Kalman Filtering for Enhanced Bubble Tracking in Motion-Compensated Ultrasound Localization Microscopy [0.03%]
基于运动补偿的超声定位显微成像中增强气泡追踪的速度约束卡尔曼滤波方法
Yifei Zhu,Lingyin Jiang,Qi Zhang et al.
Yifei Zhu et al.
Ultrasound localization microscopy (ULM) is a novel imaging technique that overcomes the diffraction limit to achieve super-resolution imaging at the 10-μm scale. Despite its remarkable progress, challenges persist in enhancing the precisi...
One-Degree-of-Freedom Mechanical Metamaterials with Arbitrary Prescribability and Rapid Reprogrammability of Force-Displacement Curves [0.03%]
具备任意力位移曲线的自由度力学 metamaterials 及其快速重构能力
Hui Li,Wei Li,Huixin Yang et al.
Hui Li et al.
Mechanical metamaterials, by introducing porous structures into the materials, can achieve complex nonlinear responses through the large deformation of structures, which support a new generation of impact energy absorption and vibration dam...