Recent Development of the Laser Interferometer for Taiji Space Gravitational Wave Detection [0.03%]
太极空间引力波探测的激光干涉仪最新进展
Heshan Liu,Juan Wang,Wei Tao et al.
Heshan Liu et al.
In this study, we have designed a full-function interferometer OB (optical bench) for the Taiji program and, for the first time, provided detailed parameter specifications for its interferometer system. Additionally, we constructed a first-...
Deep Eutectic Solvents Ignition-Triggered Interfacial Fusion for Structural-Grade Lignocellulosic Boards [0.03%]
深吴氏溶剂触发的界面融合制备高性能木质素纤维板
Huiru Yue,Cheng Zuo,Xinyi Hui et al.
Huiru Yue et al.
Lignocellulosic structural boards are often regarded as sustainable materials, yet most still depend on fossil-derived thermoset resins that generate volatile emissions, form weak and irreversible bonded interfaces, and complicate circular ...
Biomimetic Mammary Gland Organoid-on-a-Chip for Producing Selected Human Milk Components [0.03%]
仿生乳 gland 类器官芯片技术生产选择性人乳成分
Xiang Lin,Yi Cheng,Junqi Zhao et al.
Xiang Lin et al.
Milk is an essential nutritional source for human health, yet developing efficient and sustainable indoor dairy production systems to produce milk-associated components remains a major challenge. Here, we propose a biomimetic mammary gland-...
CircRAD23B-208aa Promotes Gastric Cancer Progression by Activating the Unfolded Protein Response through PDIA5 SUMOylation [0.03%]
Circular RNA CircRAD23B-208a通过PDIA5的SUMO化促进胃癌进程
Yuli Chen,Jiahao Guo,Ziwei Li et al.
Yuli Chen et al.
Gastric cancer (GC) remains a lethal malignancy with limited therapeutic options and poor prognosis. In this study, we employed integrated RNA sequencing and ribosome nascent-chain complex sequencing analyses to identify a coding circular R...
Revealing G4 Structures as Drug Targets: Exploring the Potential of Novel Therapeutic Agents [0.03%]
揭示G4结构作为药物靶点：探索新型治疗剂的潜力
Ying Che,Yi Peng,Xiaolong Pan et al.
Ying Che et al.
G-quadruplex (G4) structures represent noncanonical secondary formations found in DNA and RNA. Recent research reveals that G4s are abnormally enriched in various cancers, with closely linked to malignancy, metastatic potential, and prognos...
Evolution of 3D-Printed Microneedles toward Closed-Loop Theranostic Platforms [0.03%]
基于3D打印的微针向封闭式诊疗平台的发展
Chuan Yang,Xinxin Yan,Yue Hou et al.
Chuan Yang et al.
Advancements in biomedical interfaces increasingly demand technologies that can seamlessly bridge the gap between biological tissues and therapeutic systems. Microneedle (MN) technology has emerged as a minimally invasive platform for trans...
David Stegner
David Stegner
TNM-Accountable Whole-Body 3-Dimensional Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Report Drafting in Lung Cancer Cohorts via Structured Impressions and Organ-wise Exemplar Synthesis [0.03%]
基于结构化描述和分器官示例合成的肺癌队列中的TNM问责制全身三维氟脱氧葡萄糖正电子发射/X线计算机断层成像报告起草研究
Hang Wang,Xingyu Xie,Entao Liu et al.
Hang Wang et al.
Whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is central to lung cancer staging, yet report drafting remains time intensive and error sensitive, as a single mislocalized finding can alte...
M2 Macrophages Attenuate AQP2+ Collecting Duct Cell Apoptosis via the TRAF1-TRAF2 Complex to Suppress Randall's Plaque Formation [0.03%]
M2型巨噬细胞通过TRAF1-TRAF2复合体抑制AQP2+集合管细胞凋亡以抑制Randall plaque形成
Liang Tang,Zhangcheng Liao,Meng Gao et al.
Liang Tang et al.
Calcium oxalate (CaOx) kidney stones are common and recur frequently, yet effective pharmacological prevention is limited. Randall's plaques (RPs), calcium deposits on renal papillae, act as anchoring sites for CaOx crystal growth, but the ...
Dual-Mechanism Aptamer-Drug Complex Overcomes Paclitaxel Resistance in Ovarian Cancer via Structural Constraint and Telomerase Inhibition [0.03%]
基于结构约束和端粒酶抑制的双机制寡核苷酸-药物复合物克服卵巢癌紫杉醇耐药性
Yuan Ma,Zefeng Chen,Xinyang Shen et al.
Yuan Ma et al.
Paclitaxel resistance and poor tumor selectivity remain significant challenges in epithelial ovarian cancer therapy. To overcome these challenges, we engineered PSaA360, a structurally constrained aptamer-drug conjugate with a dual-function...