Constructing Cell-Specific Causal Networks of Individual Cells for Depicting Dynamical Biological Processes [0.03%]
构造单细胞特定的因果网络以描述动态生物学过程
Xinzhe Huang,Luonan Chen,Xiaoping Liu
Xinzhe Huang
Causal inference is crucial in biological research, as it enables the understanding of complex relationships and dynamic processes that drive cellular behavior, development, and disease. Within this context, gene regulatory network (GRN) in...
A Review of Intense Electromagnetic Fields in Heavy-Ion Collisions: Theoretical Predictions and Experimental Results [0.03%]
强离子碰撞中的强电磁场：理论预言与实验进展综述
Diyu Shen,Jinhui Chen,Xu-Guang Huang et al.
Diyu Shen et al.
In heavy-ion collisions at relativistic energies, the incident nuclei travel at nearly the speed of light. These collisions deposit kinetic energy into the overlap region and create a high-temperature environment where hadrons "melt" into d...
Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma [0.03%]
基于肿瘤微环境的影像组学模型预测局部区域晚期鼻咽癌患者免疫治疗疗效及预后
Jie Sun,Xuewei Wu,Xiao Zhang et al.
Jie Sun et al.
Background: No robust biomarkers have been identified to predict the efficacy of programmed cell death protein 1 (PD-1) inhibitors in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). We aimed to develop radiomic model...
Unraveling the Role of the Microbiota in Cancer Immunotherapy: A New Frontier [0.03%]
揭秘微生物组在癌症免疫治疗中的作用：一个新的前沿领域
Shouliang Wang,Shun Li,Mengli Zhang et al.
Shouliang Wang et al.
Cancer immunotherapy has greatly changed the therapeutic landscape for metastatic malignancies. Nevertheless, due to immune-related adverse events, drug resistance, and other factors, cancer immunotherapy remains largely untapped. Recent re...
Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction [0.03%]
单细胞RNA测序及多组学分析揭示针刺减少美沙酮用量的临床效应
Yiming Chen,Baochao Fan,Jingchun Zeng et al.
Yiming Chen et al.
Opioid use disorders (OUDs) pose a substantial global health burden, with methadone maintenance treatment (MMT) widely adopted as an intervention; however, MMT is associated with immunosuppression, metabolic disturbances, and dysbiosis of t...
Processable Bio-Based Polybenzoxazine with Tunable Toughness and Dielectric Properties [0.03%]
一种具有可调力学性能和介电性能的可加工型生物基聚苯并噁嗪树脂
Jiale Li,Meng Liu,Yuan Liu et al.
Jiale Li et al.
There is remarkable demand for bio-based specialty resins such as benzoxazine thermosets, but they are brittle and difficult to process. This study reports the synthesis of a processable bio-based polybenzoxazine resin via the copolymerizat...
Vision Gaze-Driven Micro-Electro-Mechanical Systems Light Detection and Ranging Optimization [0.03%]
基于视觉注视驱动的微机电激光雷达优化技术
Shaotang Wei,Bo Gao,Junya Wang et al.
Shaotang Wei et al.
Micro-electro-mechanical systems (MEMS) light detection and ranging (LiDAR) systems are widely employed in diverse applications for their precise ranging and high-resolution imaging capabilities. However, conventional Lissajous scanning pat...
Advancements in Protein Kinase Inhibitors: From Discovery to Clinical Applications [0.03%]
蛋白激酶抑制剂的研发进展及临床应用
Salem Baldi,Nanbiao Long,Shu Ma et al.
Salem Baldi et al.
Protein kinases are key mediators of cellular signaling and control cell functions through the phosphorylation of target proteins. They have become major targets for therapeutic agents aimed at treating human diseases, particularly cancer. ...
Systemic IFN-I Synergizes with Topical TLR7/8 Agonists to Suppress Metastatic Tumors [0.03%]
系统性干扰素I与局部TLR7/8激动剂协同抑制转移性肿瘤
Haiting Xu,Chenghui Wang,Bo Xiao
Haiting Xu
Advancing targeted cancer immunotherapy is pivotal for overcoming distant metastasis and tumor relapse. The recent study in Nature Cancer by Sanlorenzo et al. demonstrates a breakthrough strategy combining systemic type I interferon with to...
Instant Energy Barrier Modulation in Bistable Robotic Grippers for Compliant Triggering and Powerful Grasping [0.03%]
基于双稳态的机器人 gripper 的瞬时能量屏障调节以实现柔顺触发光强抓取
Jie Zhang,Hao Yang,Chenyu He et al.
Jie Zhang et al.
Bistable structures, which leverage mechanical instability, have emerged as a promising paradigm in the development of robotic grippers, providing advantages including rapid response and low energy consumption. A critical limitation of exis...