Omega-3 Fatty Acids Regulate Mammary Gland Lipogenesis and Development via Gαs-Mediated cAMP-EPAC Signaling Pathway [0.03%]
ω-3多不饱和脂肪酸通过Gαs介导的cAMP-EPAC信号通路调节乳腺脂质生成和发育
Baofeng Li,Senlin Su,Siyu Yuan et al.
Baofeng Li et al.
G protein-coupled receptor 120 (GPR120) plays a pivotal role in regulating lactation, yet its underlying mechanisms remain unclear. In mouse models, GPR120 expression in the mammary gland increases markedly during lactation. Under inflammat...
Microbubble-Templated Immunoactive Metal-Phenolic Capsules for Drug Delivery and Enhanced Cancer Immunotherapy [0.03%]
微气泡模板免疫活性金属-酚胶囊用于药物输送及增强癌症免疫治疗
Xin Tan,Xiaojing Wu,Renwang Sheng et al.
Xin Tan et al.
Advanced drug delivery systems integrating immunomodulatory functions can improve cancer therapy. Herein, we develop a novel metal-phenolic capsule for synergistic drug delivery and immunomodulation. Specifically, a stable metal-phenolic ne...
Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1 [0.03%]
DAURISOL通过靶向LRP1调节TBK1依赖的Ⅰ型干扰素通路从而增强抗肿瘤免疫反应
Borui Tang,Yuting Wang,Liping Li et al.
Borui Tang et al.
A promising therapeutic approach in oncology involves immune checkpoint blockade (ICB), which stimulates anti-tumor immune responses. Nevertheless, the effectiveness of this treatment in clinical settings remains limited, underscoring the n...
Temperature-Responsive Microrobot for High-Temperature Sensing in Constrained Environments [0.03%]
用于狭小空间高温感应的温度响应微机器人
Shaobo Ding,Junmin Liu,Jiaxu Dong et al.
Shaobo Ding et al.
Temperature measurement in confined environments has long been a substantial challenge. Due to poor accessibility to constrained space, and low visibility, conventional thermometry and existing nanoscale thermometers struggle to achieve eff...
Memristor-Based Artificial Neural Networks for Hardware Neuromorphic Computing [0.03%]
基于忆阻器的人工神经网络硬件神经形态计算
Boyan Jin,Zhenlong Wang,Tianyu Wang et al.
Boyan Jin et al.
Artificial neural networks have long been studied to emulate the cognitive capabilities of the human brain for artificial intelligence (AI) computing. However, as computational demands intensify, conventional hardware based on transistor an...
Artificial Intelligence-Powered Insights into Polyclonality and Tumor Evolution [0.03%]
人工智能驱动的多克隆性及肿瘤进化分析解读
Hong Zhao,Trey Ideker,Stephen T C Wong
Hong Zhao
Recent studies have revealed that polyclonality-where multiple distinct subclones cooperate during early tumor development-is a critical feature of tumor evolution, as demonstrated by Sadien et al. and Lu et al. in Nature (October 2024). Th...
Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools [0.03%]
利用先进的基因编辑工具精准修正导致视网膜退行性疾病的PDE6B-L659P突变并实现最小的旁观者效应编辑
Zhiquan Liu,Siyu Chen,Yang Sun
Zhiquan Liu
Recently developed base editing (BE), prime editing (PE), and click editing (CE) technologies enable precise and efficient genome editing with minimal risk of double-strand breaks and associated toxicity. However, their effectiveness in cor...
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury [0.03%]
新生启发的重新编程小胶质细胞程序性细胞死亡增强成人脊髓损伤修复
Beibei Yu,Yongfeng Zhang,Yujie Yang et al.
Beibei Yu et al.
In adult mammals, programmed cell death (PCD) facilitates tissue remodeling and regeneration in spinal cord injury (SCI), but excessive activation impedes SCI repair. However, no comprehensive pan-PCD atlas exists that encompasses diverse c...
Self-Powered Microsystem for Ultra-Fast Crash Detection via Prestressed Triboelectric Sensing [0.03%]
预应力摩擦发电的微系统实现超快碰撞预警功能
Yiqun Wang,Yuhan Wang,Xinzhi Liu et al.
Yiqun Wang et al.
Reliable detection of high-g shocks in extreme impact scenarios, such as automobile collisions, is essential for ensuring occupant safety. Conventional shock sensors based on piezoresistive or capacitive mechanisms often underperform in hig...
Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study [0.03%]
2021至2050年全球外周动脉疾病负担预测：基于人口的队列研究
Liling Deng,Chenzhen Du,Lu Liu et al.
Liling Deng et al.
Vascular disease is the leading cause of death worldwide. Predicting the burden of vascular disease and identifying modifiable key risk factors are critical for developing effective prevention strategies. This study aimed to project the glo...