Long-Term Cigarette Smoke Exposure Promotes Neutrophil Ferroptosis Resistance, Inducing Neutrophil Extracellular Trap Formation and Driving Glucocorticoid Resistance in Chronic Obstructive Pulmonary Disease [0.03%]
长期吸烟暴露促进慢性阻塞性肺疾病中性粒细胞铁死亡抵抗、诱导中性粒细胞胞外陷阱形成并引起糖皮质激素耐药性
Lu Wang,Lijie Zhu,Ying Tang et al.
Lu Wang et al.
Glucocorticoid resistance increases the frequency of acute exacerbations and the risk of death in chronic obstructive pulmonary disease (COPD) patients with a history of long-term heavy smoking. In this study we aimed to investigate the rol...
Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables [0.03%]
太赫兹单极刺激包络对细胞膜通讯相关变量影响的研究
Wenfei Bo,Rong Che,Feng Jia et al.
Wenfei Bo et al.
The development of terahertz science and technology has shown new application prospects in artificial intelligence. Terahertz stimulation can lead to information communication of cells. Terahertz unipolar picosecond pulse train stimulation ...
Luteolin Nanomedicine with Stimulus-Driven Traceless Release for Targeting Treatment of Atherosclerosis by Enhancing Lipid Efflux [0.03%]
一种用于治疗动脉粥样硬化的纳米药物，能响应刺激无痕微量释放黄芩苷以增强脂质外流作用
Songzan Chen,Zhaojing Wang,Zhida Shen et al.
Songzan Chen et al.
Atherosclerotic plaques pose a substantial risk for life-threatening cardiovascular complications due to their propensity to trigger acute clinical events. Foam cell formation, resulting from dysregulated lipid homeostasis, serves as a pivo...
The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells [0.03%]
共凝集蛋白复合体在干细胞命运决定过程中的功能和机制研究
Jianghong Xiang,Yihan Lai,Zuping He
Jianghong Xiang
Stem cells have important applications in both regenerative and reproductive medicine. The cohesin complex comprises 4 core subunits, namely, SMC1, SMC3, RAD21, and STAG, and notably, it plays pivotal roles in controlling the fate determina...
Machine Learning-Assisted Development of Injectable, Mechanically Robust, and Energy Metabolism-Modulating Brushite Cements [0.03%]
机器学习辅助开发可注射、机械坚固且能调节能量代谢的刷石水泥
Dachuan Liu,Jiaxu Shi,Youhao Ni et al.
Dachuan Liu et al.
In orthopedic minimally invasive surgeries (MIS) such as percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP), calcium phosphate cements (CPCs) are an attractive alternative to bioinert polymethyl methacrylate (PMMA) due to ...
IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1-STAT1-IDO Axis and Tryptophan Metabolic Orchestration [0.03%]
通过JAK1-STAT1-IDO轴和色氨酸代谢的调节，IL-27通过调节间充质干细胞的免疫可塑性来增强狼疮性肾炎的治疗
Cheng Zhou,Shunlai Shang,Jing Zhao et al.
Cheng Zhou et al.
Lupus nephritis is recognized as a common and severe complication of systemic lupus erythematosus, without an optimal therapeutic strategy currently available. While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy var...
E3 Ligase Rbx1 Orchestrates Thymus Development and Fate Determination of αβ-γδ T Cells [0.03%]
E3泛素连接酶Rbx1调控胸腺发育及αβ-γδT细胞命运决定
Di Wu,Qiuxu Chen,Mingjia Tan et al.
Di Wu et al.
T lymphocytes consist of αβ and γδ T cells, which mature and differentiate from the same progenitor cells in the thymus. Cullin-RING ligases (CRLs), the largest family of ubiquitin ligases, require neddylation on the scaffold protein Cu...
SpatConv Enables the Accurate Prediction of Protein Binding Sites by a Pretrained Protein Language Model and an Interpretable Bio-spatial Convolution [0.03%]
基于预训练的蛋白质语言模型和可解释生物空间卷积的精确预测蛋白质结合位点（SpatConv）
Mingming Guan,Jiyun Han,Shizhuo Zhang et al.
Mingming Guan et al.
Protein interactions with molecules, such as other proteins, peptides, or small ligands, play a critical role in biological processes, and the identification of protein binding sites is crucial for understanding the mechanisms underlying di...
Nanomaterial Adjuvants for Veterinary Vaccines: Mechanisms and Applications [0.03%]
用于兽医疫苗的纳米材料佐剂：机制和应用
Li He,Ruliang Pan,Rui Liang et al.
Li He et al.
Safe and effective veterinary vaccines prevent infectious diseases and reduce morbidity. In this field, nanovaccines based on nanomaterials are emerging, showing great potential as innovative alternatives to conventional vaccines. This pape...
Gravitational Equivalence Theorem and Double-Copy for Kaluza-Klein Graviton Scattering Amplitudes [0.03%]
卡拉布拉-克莱因引力子散射幅的等价定理与双算符理论
Yan-Feng Hang,Hong-Jian He
Yan-Feng Hang
We analyze the structure of scattering amplitudes of the Kaluza-Klein (KK) gravitons and of the KK gravitational Goldstone bosons in the compactified 5d general relativity (GR). Using a general R ξ gauge fixing, we study the geometr...