Ruochen Qiao,Dasheng Li,Long Wang et al.
Ruochen Qiao et al.
Cell-based therapeutics hold immense promise for clinical intervention, yet their practical translation is severely bottlenecked by suboptimal delivery kinetics, safety risks, and low patient adherence. This review provides a comprehensive ...
Xiaolu Han,Jun Zhang,Jiahui Bai et al.
Xiaolu Han et al.
Emerging and re-emerging infectious diseases ranging from the 1918 H1N1 influenza pandemic to the recent SARS-CoV-2 and monkeypox virus outbreaks continue to pose profound threats to global public health. These crises underscore the critica...
A New Fluorine-18-Fluoroethyltyrosine Positron-Emission-Tomography/Magnetic-Resonance-Based Tumor Resection Plan Improved the Prognosis of Glioblastoma Patients. A Multicenter Validated Study [0.03%]
一项多中心验证研究：新的18F-FET-PET/MR肿瘤切除计划可改善胶质母细胞瘤患者的预后
Ye Cheng,Xiaolong Wu,Bixiao Cui et al.
Ye Cheng et al.
Background: Glioblastoma, IDH-wild-type, is a highly invasive tumor, and prognosis largely depends on the extent of resection. Contrast-enhanced (CE) MRI often underestimates tumor borders, resulting in incomplete resection. Prospective mul...
Metabolic Reprogramming and Immunometabolic Dysregulation in Diabetic Kidney Disease: From Pathogenesis to Precision Multi-target Therapies [0.03%]
糖尿病肾病中的代谢重组与免疫代谢失调：从发病机制到精准多靶点治疗
Ziyue Zhang,Yilun Qu,Xiaochen Wang et al.
Ziyue Zhang et al.
Diabetic kidney disease, the leading cause of end-stage kidney disease worldwide, involves complex interactions beyond classical hemodynamic and oxidative stress pathways. Recent advances emphasize metabolic reprogramming in renal cells-cha...
HO-1 Up-regulation and PINK1/Parkin-Mediated Mitophagy Contribute to the Anti-tumor Effects of Metochalcone in Colorectal Cancer [0.03%]
HO-1上调和PINK1/Parkin介导的线粒体自噬协同促进metochalcone在结直肠癌中的抗肿瘤作用
Pingting Chen,Junsha An,Mingyu Han et al.
Pingting Chen et al.
Colorectal cancer (CRC) remains a global health challenge with rising incidence in younger populations and limited efficacy of current chemotherapies. In this study, we investigated the anti-tumor mechanisms of metochalcone (MET), a natural...
Zhe Liu,Oscar Gonzalez,Minli You et al.
Zhe Liu et al.
Cancer-related lymphedema is a chronic progressive side effect of cancer treatments followed by lymph node dissection or radiotherapy. Clinicians often identify lymphedema through limb swelling, while the disease begins earlier than that. L...
FKBP5 Orchestrates a Biphasic Microglial Response in Spinal Cord Injury by Sequentially Activating the GPR84/IL-1β Pathway and the LDHA-Lactylation-FXYD5/LGALS1 Axis [0.03%]
FKBP5通过依次激活GPR84/IL-1β通路和LDHA乳酰化/FXYD5/LGALS1轴在脊髓损伤中协调小胶质细胞的双相反应
Haotian Li,Jing Wang,Daohui Li et al.
Haotian Li et al.
Spinal cord injury often causes permanent disability because the body's own repair mechanisms are limited, and the molecules that control damage and healing are not fully understood. One such molecule, FK506-binding protein 5 (FKBP5), is kn...
Thermally Induced Reassembly of Ginger Extracellular Vesicles for Oral Therapy of Intestinal Inflammation [0.03%]
热响应姜外泌体的智能重建用于口腔治疗肠道炎症
Linhai Hou,Jie Cao,Shengjie Gao et al.
Linhai Hou et al.
Plant-derived extracellular vesicles are promising candidates for oral drug delivery, yet their clinical translation is hindered by limited targeting precision and inconsistent systemic absorption. While surface engineering can enhance tiss...
Xiangdong Ji,Gerald A Miller,Chen Yang
Xiangdong Ji
The strong interaction is the fundamental force that holds quarks and the gluon force carriers together to form protons and neutrons and also binds the atomic nucleus. The theory governing quark-gluon interactions is quantum chromodynamics ...
Antimicrobial Nanozymes: Structure-Activity-Guided Design, Synergy, and Applications [0.03%]
抗菌纳米酶：结构-活性导向设计、协同效应及应用
Yuan Liu,Kaili Guo,Jingnan Shi et al.
Yuan Liu et al.
Nanozymes are emerging as versatile antimicrobial agents to tackle drug-resistant infections and biofilm-associated persistence. In this review, we present an integrated framework that links natural enzyme-mediated host defense to the ratio...