A Scalable, High-Efficiency, Low-Energy-Spread Laser Wakefield Accelerator Using a Tri-Plateau Plasma Channel [0.03%]
一种采用三段平坦区域等离子体通道的可扩展、高效率和低能量展宽的激光尾场加速器
Shuang Liu,Fei Li,Shiyu Zhou et al.
Shuang Liu et al.
The emergence of multi-petawatt laser facilities is expected to push forward the maximum energy gain that can be achieved in a single stage of a laser wakefield acceleration (LWFA) to tens of giga-electron volts, which begs the question-is ...
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism [0.03%]
线粒体自噬通过激活谷胱甘肽代谢促进毛发再生
Dehuan Wang,Jingwei Jiang,Mengyue Wang et al.
Dehuan Wang et al.
Mitophagy maintains tissue homeostasis by self-eliminating defective mitochondria through autophagy. How mitophagy regulates stem cell activity during hair regeneration remains unclear. Here, we found that mitophagy promotes the proliferati...
Bioinspired Zwitterionic Block Polymer-Armored Nitric Oxide-Generating Coating Combats Thrombosis and Biofouling [0.03%]
受生物启发的两性离子嵌段聚合物武装的生成一氧化氮涂层以对抗血栓和生物污染
Qing Ma,Wentai Zhang,Xiaohui Mou et al.
Qing Ma et al.
Thrombosis and infection are 2 major complications associated with central venous catheters (CVCs), resulting in substantial mortality and morbidity. The concurrent long-term administration of antibiotics and anticoagulants to address these...
Swarming Magnetic Fe3O4@Polydopamine-Tannic Acid Nanorobots: Integrating Antibiotic-Free Superficial Photothermal and Deep Chemical Strategies for Targeted Bacterial Elimination [0.03%]
聚集的磁性Fe3O4@多巴胺-单宁酸纳米机器人：集成无抗生素的表面光热和深度化学策略用于靶向消除细菌
Luying Si,Shuming Zhang,Huiru Guo et al.
Luying Si et al.
Micro/nanorobots (MNRs) are envisioned to provide revolutionary changes to therapies for infectious diseases as they can deliver various antibacterial agents or energies to many hard-to-reach infection sites. However, existing MNRs face sub...
Wei Yang,Hua Yue,Guihong Lu et al.
Wei Yang et al.
Oxidation modulators regarding antioxidants and reactive oxygen species (ROS) inducers have been used for the treatment of many diseases. However, a systematic review that refers to delivery system for divergent modulation of oxidative leve...
Highly Accurate and Efficient Deep Learning Paradigm for Full-Atom Protein Loop Modeling with KarmaLoop [0.03%]
基于KarmaLoop的高精度高效全原子蛋白质环建模方法
Tianyue Wang,Xujun Zhang,Odin Zhang et al.
Tianyue Wang et al.
Protein loop modeling is a challenging yet highly nontrivial task in protein structure prediction. Despite recent progress, existing methods including knowledge-based, ab initio, hybrid, and deep learning (DL) methods fall substantially sho...
Yong Luo,Yongchao Song,Jing Wang et al.
Yong Luo et al.
Cell culture as the cornerstone of biotechnology remains a labor-intensive process requiring continuous manual oversight and substantial time investment. In this work, we propose an integrated mini-pillar platform for in situ monitoring of ...
Liquid Biopsy Instrument for Ultra-Fast and Label-Free Detection of Circulating Tumor Cells [0.03%]
一种用于快速无标记检测循环肿瘤细胞的液体活检仪器
Shu Zhu,Zhixian Zhu,Chen Ni et al.
Shu Zhu et al.
Rapid diagnosis and real-time monitoring are of great important in the fight against cancer. However, most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive. Here, we describe CytoExam, an au...
Integrated Cross-Scale Manipulation and Modulable Encapsulation of Cell-Laden Hydrogel for Constructing Tissue-Mimicking Microstructures [0.03%]
基于细胞的水凝胶微结构模块化封装及跨尺度操控构建技术
Yanfeng Zhao,Xinyi Dong,Yang Li et al.
Yanfeng Zhao et al.
Engineered microstructures that mimic in vivo tissues have demonstrated great potential for applications in regenerative medicine, drug screening, and cell behavior exploration. However, current methods for engineering microstructures that ...
Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System [0.03%]
抵抗素通过内源大麻素系统在人体中调节炎症和胰岛素抵抗
Han-Mo Yang,Joonoh Kim,Baek-Kyung Kim et al.
Han-Mo Yang et al.
Resistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insu...