The androgen receptor amino-terminal domain: structure, function and therapeutic potential [0.03%]
雄激素受体氨基末端结构域：构象，功能及治疗潜能
Irene Hunter,Craig Jamieson,Iain J McEwan
Irene Hunter
Signalling by the steroid hormone testosterone involves the androgen receptor (AR), a structurally dynamic protein. The amino-terminal domain of the AR makes up more than half of the protein and has been found to be intrinsically disordered...
Anthony J McGoron,Jose M Garcia,Burulça Uluvar et al.
Anthony J McGoron et al.
Radioactive iodine (RAI) treatment is an established therapeutic tool for 'differentiated thyroid cancers'. The therapeutic effectiveness is linked to the preservation of the iodine-concentrating ability of the neoplastic tissue, a unique, ...
Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits [0.03%]
小肠神经内分泌肿瘤的手术规划：肠系膜肿瘤病灶的概念
Romain L&#x;Huillier,Gilles Poncet,Arnaud Pasquer et al.
Romain L&#x;Huillier et al.
The mesenteric extension of small neuroendocrine tumors is the surgical limiting factor because of the risk of postoperative short bowel syndrome due to superior mesenteric artery involvement. Recent pathological studies have shown that thi...
Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers [0.03%]
通过数学建模改进神经内分泌肿瘤的治疗：从其他内分泌癌中获得的经验
John Metzcar,Rachael Guenter,Yafei Wang et al.
John Metzcar et al.
Neuroendocrine tumors (NETs) occur sporadically or as part of rare endocrine tumor syndromes (RETSs) such as multiple endocrine neoplasia 1 and von Hippel-Lindau syndromes. Due to their relative rarity and lack of model systems, NETs and RE...
The natural course of cystic pancreatic neuroendocrine tumours in MEN1 [0.03%]
多重内分泌腺瘤病中胰腺囊性神经内分泌肿瘤的自然进程
Eline N M van Vliembergen,Carolina R C Pieterman,Annenienke C van de Ven et al.
Eline N M van Vliembergen et al.
Pancreatic neuroendocrine tumours (PanNETs) significantly impact life expectancy in multiple endocrine neoplasia type 1 (MEN1). Both solid and cystic pancreatic lesions are observed in MEN1, yet limited research has been focused on cystic l...
Aripiprazole use as a cause of dopamine agonist failure in the treatment of prolactinomas [0.03%]
阿立哌唑致泌乳素瘤多巴胺激动剂治疗失效病例报告
Edward Mignone,Alistair K Jukes,Rowan Valentine et al.
Edward Mignone et al.
Prolactinomas are the most common hypersecretory pituitary adenoma. The traditional first-line therapy is dopamine agonists (DAs), which are highly effective and tolerated in the majority of cases. However, DAs have the potential for psychi...
NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations [0.03%]
2024年NET模型会议白皮书：神经内分泌肿瘤研究模型的现状及未来展望
Po Hien Ear,Ilaria Marinoni,Talya Dayton et al.
Po Hien Ear et al.
Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and ...
Treatment with BRAF/MEK: inhibitors in mutant BRAF V600E papillary craniopharyngioma [0.03%]
BRAF/V600E突变的垂体乳头状颅咽管瘤的BRAF/MEK抑制剂治疗
Eva Marie Erfurth,Peter Siesjö,Pia C Sundgren et al.
Eva Marie Erfurth et al.
Summary: Craniopharyngiomas (CPs) are rare brain epithelial tumours arising in the suprasellar region, infiltrating adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity. Papillary ...
Expression of MMP-2, MMP-9 and TIMP-2 in pituitary tumors and their relationship with cavernous sinus invasion [0.03%]
基底节区脑出血的血管病因学及临床特点分析
Ane Caroline Thé B Freire,Raquel S Jallad,Rafael L Batista et al.
Ane Caroline Thé B Freire et al.
Objective: To evaluate the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-2 (TIMP-2) in pituitary tumors and investigate their correlation with circulating plasma protein...
A rare case of bladder paraganglioma treated successfully with robotic partial cystectomy [0.03%]
机器人辅助下膀胱部分切除术成功治疗一例罕见的膀胱副神经节瘤患者
Kalyan M Shekhda,Jessal M Palan,Christo B Albor et al.
Kalyan M Shekhda et al.
Bladder paragangliomas are rare extra-adrenal urological tumors that account for around 0.05% of bladder cancers. Their diagnosis is often delayed because of the rarity of these tumors. There is a risk of an intraoperative hypertensive cris...