Characterisation of a GNAS variant linked to cortisol-producing adrenocortical adenoma [0.03%]
GNAS变异体与皮质醇产生肾上腺腺瘤的特征化研究
Aqfan Jamaluddin,Rachael Wyatt,Andreea Pasaliu et al.
Aqfan Jamaluddin et al.
Objective: Adrenocortical adenomas are frequent in the general population and can be associated with autonomous cortisol excess, increasing morbidity and mortality. Altered cAMP/PKA signalling is common in sporadic cortis...
Octreotide infusion pump in patients with functional neuroendocrine tumors and refractory hormonal syndrome [0.03%]
长效奥曲肽输液泵在难治性功能性神经内分泌肿瘤患者中的应用研究
Kalyan Mansukhbhai Shekhda,Eleni Armeni,Dalvinder Mandair et al.
Kalyan Mansukhbhai Shekhda et al.
Objective: To evaluate clinical outcomes, safety and survival measures of octreotide infusion pump (OIP) therapy in patients with metastatic neuroendocrine tumors (NETs) and refractory hormonal syndrome. ...
Validity of geographic-level social determinant of health metrics in pancreatic neuroendocrine tumors [0.03%]
胰腺神经内分泌肿瘤中地理水平的健康社会决定因素指标的有效性
Andrea Gillis,Brendon Herring,Rachael Guenter et al.
Andrea Gillis et al.
Various social determinants of health (SDOH) metrics, also known as area-based social measures, are utilized to evaluate access to cancer care and to explain disparities in outcomes. Little prior work has compared the validity of these vari...
Clinical characteristics and prognosis of histological subtypes of papillary thyroid carcinoma in pediatric patients [0.03%]
儿童乳头状甲状腺癌不同组织学类型的特点及预后分析
Junko Akaishi,Kiminori Sugino,Tetsuo Kondo et al.
Junko Akaishi et al.
The purpose of this study was to clarify the clinicopathological features and prognosis of histological subtypes of papillary thyroid carcinoma (PTC) in the pediatric population treated at a single institution. A total of 153 PTC patients ...
Emergency and routine presentation of neuroendocrine neoplasia in England: determinants of late presentation and survival outcomes [0.03%]
英国神经内分泌肿瘤急性和常规诊疗：晚期诊断的决定因素及生存结果分析
Marie Line El Asmar,Mohamed Mortagy,Benjamin E White et al.
Marie Line El Asmar et al.
Objective: The time from onset of symptoms of neuroendocrine neoplasia (NEN) to diagnosis ranges between 5 and 7 years. Risk factors associated with this and the difference in overall survival (OS) between routine and eme...
HHLA2: a potential biomarker and therapeutic target in endocrine-related cancer [0.03%]
HHLA2：与内分泌相关的癌症生物标志物和治疗靶点
Christiane Gruetzmacher,Bruna Sousa Pessoa,Flora Ladeira Craveiro et al.
Christiane Gruetzmacher et al.
Purpose: Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2), a member of the B7 family, is widely expressed across human cancers and is emerging as a promising immune checkpoint target for therapeuti...
Prospective cohort of pre-diagnosis hormone exposure and post-diagnosis sex hormone levels with survival outcomes: Alberta Endometrial Cancer Cohort Study [0.03%]
绝经前激素暴露和诊断后性激素水平与生存结果的前瞻性队列研究：艾伯塔子宫内膜癌队列研究
Jamie L Benham,Renée L Kokts-Porietis,Jessica McNeil et al.
Jamie L Benham et al.
Purpose: To examine the associations between pre-diagnosis exogenous hormone exposure and endogenous sex hormone levels shortly after diagnosis with survival outcomes in endometrial cancer survivors. ...
Mark A Jara,Luciana Audi Castroneves
Mark A Jara
Medullary thyroid carcinoma (MTC) is a rare cancer of the thyroid's calcitonin-producing C cells. This review covers recent advances in MTC treatment, emphasizing surgical and systemic therapies. For localized MTC, surgery remains the prima...
Oral cancer cells secrete stress neurotransmitter and proliferate in response to tobacco carcinogen NNK [0.03%]
口腔癌细胞分泌应激神经递质并响应烟草致癌物NNK而增殖
Flávia Alves Verza,Ana Lívia Santos-Sousa,Sandra Helena Penha Oliveira et al.
Flávia Alves Verza et al.
Purpose: Although there is a growing body of evidence showing the effects of stress-related catecholamines on oral cancer progression, to date there are no studies that have investigated whether oral squamous cell carcino...
Acute severe hypocalcaemia after initiation of a selective RET-inhibitor in medullary thyroid cancer [0.03%]
髓样甲状腺癌使用选择性RET抑制剂后出现急性严重低钙血症
Leslie Cheng,Syeda Khadijah Ghaznavi,Jessica Stevens et al.
Leslie Cheng et al.
Medullary thyroid cancer (MTC) is a rare subtype of thyroid cancer originating from parafollicular C-cells of the thyroid. Tyrosine kinase inhibitors are used to treat patients with advanced MTC. Selpercatinib is a highly selective RET inhi...