Adjuvant therapy in adrenocortical carcinoma: prognostic factors and treatment options [0.03%]
肾上腺皮质癌的辅助治疗：预后因素和治疗选择
Ruaa Al-Ward,Celeste Zsembery,Mouhammed Amir Habra
Ruaa Al-Ward
Adrenocortical carcinoma (ACC) is a rare cancer with high recurrence rates and heterogeneous clinical behavior. The role of adjuvant therapy remains unclear because of the challenges in collecting high-quality data for a rare cancer. The cu...
Characterization of hyperlipidemia secondary to mitotane in adrenocortical carcinoma [0.03%]
肾上腺皮质癌导致的密妥坦继发性高脂血症的特点分析
Nadia Gagnon,Sophie Bernard,Martine Paquette et al.
Nadia Gagnon et al.
Background: This study examined the magnitude of changes and the time required to observe maximal changes in LDL-c, HDL-c, triglycerides (Tg) and non-HDL-c after the introduction of mitotane. ...
Pituitary carcinoma: reclassification and implications in the NET schema [0.03%]
垂体癌：在NET分型中的再分类及其影响
Sylvia L Asa,Shereen Ezzat
Sylvia L Asa
The entity known as pituitary carcinoma has been traditionally defined as a tumor of adenohypophysial cells that metastasizes systemically or craniospinally independent of the histological appearance of the lesion. Reported cases of pituita...
Molecular mechanisms involved in somatostatin receptor regulation in corticotroph tumors: the role of cytoskeleton and USP8 mutations [0.03%]
促肾上腺皮质激素分泌肿瘤中生长抑素受体调控的分子机制：细胞骨架和USP8突变的作用
Erika Peverelli,Donatella Treppiedi,Giovanna Mantovani
Erika Peverelli
Adrenocorticotropic hormone (ACTH)-secreting pituitary tumors mainly express somatostatin receptor 5 (SSTR5) since SSTR2 is downregulated by the elevated levels of glucocorticoids that characterize patients with Cushing's disease (CD). SSTR...
Kiyoshi Takagi,Mio Yamaguchi,Minoru Miyashita et al.
Kiyoshi Takagi et al.
Breast cancer is a hormone-dependent cancer, and sex steroids play a pivotal role in breast cancer progression. Estrogens are strongly associated with breast cancers, and the estrogen receptor (estrogen receptor α; ERα) is expressed in 70...
Low but not undetectable early postoperative nadir serum cortisol predicts sustained remission in Cushing's disease [0.03%]
低但可检测的术后早期皮质醇预测库欣病的持续缓解
Anna Stroud,Pearl Dhaliwal,Richard J Harvey et al.
Anna Stroud et al.
Objective: Transsphenoidal surgery (TSS) is the first-line treatment for Cushing's disease. The objectives of the study were to determine remission and recurrence rates after TSS for Cushing's disease, identify factors th...
Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells [0.03%]
低氧刺激人甲状旁腺嗜酸细胞的血管生成及代谢转换
K E Lines,M Stevenson,R Mihai et al.
K E Lines et al.
Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may also be important for parathyroid autotransplantation in patients, are, however,...
Investigating the clinical, pathological and molecular profile of oncocytic adrenocortical neoplasms: a case series and literature review [0.03%]
肾上腺 Oncocytic 腺瘤的临床、病理及分子特征研究：病例系列和文献综述
Eleanor Fewings,Serena Khoo Sert Kim,Alexey Larionov et al.
Eleanor Fewings et al.
Background: Malignant oncocytic adrenocortical neoplasms (OANs) are rare tumours with a distinctive biological behaviour compared to conventional adrenocortical carcinoma (ACC). The current prognostic systems overestimate...
Serum osteopontin can improve papillary thyroid cancer risk assessment of Bethesda III thyroid nodules: a preliminary study [0.03%]
骨基质蛋白抗原血清学检测改善III类Bethesda甲状腺结节的风险评估：初步研究
T U Kars,M Kulaksızoğlu,I Kılınç
T U Kars
Objective: Thyroid cancer can be detected in 5-10% of patients with thyroid nodules. Management may be a challenge if fine-needle aspiration biopsy yields Bethesda III findings. Most of these cases undergo surgery and are...
Adrenocortical cancer recurrence following initial transcutaneous biopsy: a rare demonstration of needle tract seeding [0.03%]
初始经皮穿刺后的肾上腺皮质癌复发：罕见的针道种植演示病例
Nada Younes,Isabelle Bourdeau,Harold Olney et al.
Nada Younes et al.
Summary: Needle tract seeding is a potential, albeit rare, complication following transcutaneous biopsies, leading to the seeding of tumor cells along the path of the needle. Biopsies of adrenal masses are not routinely r...