Germline genetic variants in pheochromocytoma/paraganglioma: single-center experience [0.03%]
pheochromocytoma/副神经节瘤的生殖细胞遗传变异：单中心经验
José V Lima Jr,Nilza M Scalissi,Kelly C de Oliveira et al.
José V Lima Jr et al.
Pheochromocytoma and paragangliomas (PPGLs) are rare neuroendocrine tumors carrying 25-40% pathogenic germline gene variants (PGVs). We evaluated clinical, laboratory, and germline molecular profile of 115 patients with pathologic (14 patie...
Endocrine Oncology: the home for translational research in cancer and hormones [0.03%]
内分泌肿瘤学：癌症与激素转化研究的前沿阵地
Justo P Castaño
Justo P Castaño
SAKK 21/12: a phase II trial of transdermal CR1447 in breast cancer patients [0.03%]
SAKK 21/12：乳腺癌患者的CR1447透皮给药Ⅱ期临床试验
Marcus Vetter,Karin M Rothgiesser,Qiyu Li et al.
Marcus Vetter et al.
Objective: CR1447, a novel transdermal formulation of 4-hydroxytestosterone, has aromatase-inhibiting and androgen receptor (AR)-modulating properties (IC504.4 nM) with antitumor effects against AR-positive tumor cells in...
Potential pitfalls in diagnosis of immunotherapy-induced hypothalamic-pituitary-adrenal axis abnormalities: a clinical case [0.03%]
免疫治疗诱导的下丘脑-垂体-肾上腺轴异常诊断中的潜在陷阱：临床病例报告
Yixi Bi,Safwaan Adam,Viktoria Chatzimavridou et al.
Yixi Bi et al.
Summary: Short synacthen tests (SST) are frequently used for assessing adrenocorticotropin hormone (ACTH) deficiency. In this study, we present the case of a 53-year-old man receiving immunotherapy for metastatic melanoma...
Hypoparathyroidism: an uncommon adverse effect of treatment with durvalumab [0.03%]
德瓦鲁单抗治疗的少见不良反应——低甲状旁腺素血症病例报告
Alexander Kreze,Matěj Homer,Tereza Barešová et al.
Alexander Kreze et al.
Summary: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies approved for the treatment of numerous cancer types. Toxicities induced by ICIs may affect any organ system and manifest as endocrinopathy. The main s...
Pheochromocytoma and paraganglioma: germline genetics and hereditary syndromes [0.03%]
pheochromocyt瘤和副神经节瘤：遗传学及遗传病综合征
Christie G Turin,Molly M Crenshaw,Lauren Fishbein
Christie G Turin
Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors arising from the adrenal medulla and extra-adrenal ganglia, respectively. Approximately 15-25% of PCC/PGL can become metastatic. Up to 30-40% of patients with PCC/...
Synchronous AML and pancreatic neuroendocrine neoplasm, both successfully treated with somatostatin analogs and decitabine [0.03%]
成功的使用生长抑素类似物和地西他滨同步治疗急性髓系白血病及胰腺神经内分泌肿瘤
Syed Ehsanullah,Nikolaos A Trikalinos
Syed Ehsanullah
Summary: Downregulation of tumor suppression genes by DNA hypermethylation has been proposed as a potential cause of neuroendocrine neoplasm (NEN) formation. In this report, we present a patient simultaneously diagnosed w...
Nathan J Graham,Joshua D Smith,Tobias Else et al.
Nathan J Graham et al.
Head and neck paragangliomas (HNPGLs) are slow-growing, vascular, typically benign tumors whose growth may induce significant lower cranial nerve deficits. While most tumors arise sporadically, a significant portion is associated with defin...
Tumour volume is a predictor of lymphovascular invasion in differentiated small thyroid cancer [0.03%]
分化型小甲状腺癌肿瘤体积是淋巴管血管侵犯的预测因素
Krishna Vikneson,Tariq Haniff,May Thwin et al.
Krishna Vikneson et al.
Objectives: For small thyroid cancers (≤2 cm), tumour volume may better predict aggressive disease, defined by lymphovascular invasion (LVI) than a traditional single measurement of diameter. We aimed to investigate the ...
Dopamine agonist therapy for prolactinomas: do we need to rethink the place of surgery in prolactinoma management? [0.03%]
多巴胺激动剂治疗泌乳素瘤：我们还需要重新考虑手术在泌乳素瘤治疗中的作用吗？
Sunita M C De Sousa
Sunita M C De Sousa
The current treatment paradigm for prolactinomas involves dopamine agonist (DA) therapy as the first-line treatment, with surgical resection reserved for cases where there is DA failure due to resistance or intolerance. This review highligh...