Ernest M Wright,Donald D F Loo
Ernest M Wright
Dennis Brown
Dennis Brown
Dingguo Zhang,Jackson C Colson,Chunhua Jin et al.
Dingguo Zhang et al.
Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL/6J mice w...
Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks [0.03%]
内在运动能力和线粒体DNA导致相反的血管相关风险
Shaunak Roy,Jonnelle M Edwards,Jeremy C Tomcho et al.
Shaunak Roy et al.
Exercise capacity is a strong predictor of all-cause morbidity and mortality in humans. However, the associated hemodynamic traits that link this valuable indicator to its subsequent disease risks are numerable. Additionally, exercise capac...
Steven R Vigna,Rodger A Liddle
Steven R Vigna
Rainelli Koumangoye,Lisa Bastarache,Eric Delpire
Rainelli Koumangoye
Among the electroneutral Na+-dependent chloride transporters, NKCC1 had until now evaded identification as a protein causing human diseases. The closely related SLC12A transporters, NKCC2 and NCC have been identified some 25 years ago as re...
Annette C Dolphin
Annette C Dolphin
Voltage-gated calcium channels are the principal conduits for depolarization-mediated Ca2+ entry into excitable cells. In this review, the biophysical properties of the relevant members of this family of channels, those that are present in ...
Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection [0.03%]
针对SARS-CoV-2病毒感染的口腔冲洗液清除病毒包膜潜在作用分析
Valerie B O&#x;Donnell,David Thomas,Richard Stanton et al.
Valerie B O&#x;Donnell et al.
Emerging studies increasingly demonstrate the importance of the throat and salivary glands as sites of virus replication and transmission in early COVID-19 disease. SARS-CoV-2 is an enveloped virus, characterized by an outer lipid membrane ...
A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection [0.03%]
COVID-19的病理生理模型：呼吸道感染情况下上皮钠转运的重要性不容忽视
Martina Gentzsch,Bernard C Rossier
Martina Gentzsch
The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding ...
Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts [0.03%]
受损的心肌能量学导致失代偿衰竭心脏的机械功能障碍
Rachel Lopez,Bahador Marzban,Xin Gao et al.
Rachel Lopez et al.
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynthe...