A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection [0.03%]
COVID-19的病理生理模型：呼吸道感染情况下上皮钠转运的重要性不容忽视
Martina Gentzsch,Bernard C Rossier
Martina Gentzsch
The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding ...
Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts [0.03%]
受损的心肌能量学导致失代偿衰竭心脏的机械功能障碍
Rachel Lopez,Bahador Marzban,Xin Gao et al.
Rachel Lopez et al.
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynthe...
Katherine E Shipman,Ora A Weisz
Katherine E Shipman
Dent disease (DD) is a rare kidney disorder caused by mutations in the Cl-/H+ exchanger ClC-5. Extensive physiologic characterization of the transporter has begun to illuminate its role in endosomal ion homeostasis. Nevertheless, we have ye...
The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome [0.03%]
Cantú 综合征中钾通道功能增强引起高输出性心肌肥大的机制
Conor McClenaghan,Yan Huang,Scot J Matkovich et al.
Conor McClenaghan et al.
Dramatic cardiomegaly arising from gain-of-function (GoF) mutations in the ATP-sensitive potassium (KATP) channels genes, ABCC9 and KCNJ8, is a characteristic feature of Cantú syndrome (CS). How potassium channel over-activity results in c...
Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy [0.03%]
负荷诱导肥大过程中卫星细胞与肌纤维之间的融合独立通信
Kevin A Murach,Ivan J Vechetti Jr,Douglas W Van Pelt et al.
Kevin A Murach et al.
The "canonical" function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation via fusion to support increased transcriptional output. In recent years, however, emerging eviden...
Depletion of mitochondrial CypD in endothelial and smooth muscle cells attenuates vascular dysfunction and hypertension [0.03%]
线粒体CypD在线状内皮细胞和平滑肌细胞中耗尽可减轻血管功能障碍和高血压
Hypertension is a major risk factor of cardiovascular disease affecting nearly half of adult population, but only 25% patients have their blood pressure under control. Hypertension is associated with mitochondrial dysfunction; however, its ...