Tonia L Vincent
Tonia L Vincent
Choose Your Maternal DNA Wisely: Intrinsic Exercise Capacity and Mitochondrial Genome Influence Vascular Function in Rats [0.03%]
谨慎选择母系DNA：有氧运动能力和线粒体基因组影响大鼠血管功能
Austin T Robinson
Austin T Robinson
Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics [0.03%]
定量蛋白质组学鉴定MuRF1肌肉 ubiquitin 蛋白质谱图
Leslie M Baehr,David C Hughes,Sarah A Lynch et al.
Leslie M Baehr et al.
MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker...
Loss of Adam10 Disrupts Ion Transport in Immortalized Kidney Collecting Duct Cells [0.03%]
ADAM10缺失扰乱了肾集合管上皮细胞瞬时离子转运功能
Adrienne Assmus,Linda Mullins,Mairi Ward et al.
Adrienne Assmus et al.
The kidney cortical collecting duct (CCD) comprises principal cells (PCs), intercalated cells (IC), and the recently discovered intermediate cell type. Kidney pathology in a mouse model of the syndrome of apparent aldosterone excess reveale...
A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis [0.03%]
一种新的稳定同位素方法展示了骨骼肌胶原蛋白稳态随着年龄增长而意外下降的程度
Claire B Abbott,Marcus M Lawrence,Kamil A Kobak et al.
Claire B Abbott et al.
Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix fibrosis and hinders adaptation to external stimuli. This project sought to understand factors that increase skeletal muscle fibrosis with age by st...
Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise [0.03%]
卫星细胞耗尽会破坏转录协调和肌肉对运动的适应性
Davis A Englund,Vandré C Figueiredo,Cory M Dungan et al.
Davis A Englund et al.
Satellite cells are required for postnatal development, skeletal muscle regeneration across the lifespan, and skeletal muscle hypertrophy prior to maturity. Our group has aimed to address whether satellite cells are required for hypertrophi...
Ruth A Riedl,Colin M L Burnett,Nicole A Pearson et al.
Ruth A Riedl et al.
Evidence supports various roles for microbial metabolites in the control of multiple aspects of host energy flux including feeding behaviors, digestive efficiency, and energy expenditure, but few studies have quantified the energy utilizati...
PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease [0.03%]
PI(1,4,5)p3通过调节线粒体自噬改善AD模型小鼠脑血流下降及认知缺陷
Amreen Mughal,Osama F Harraz,Albert L Gonzales et al.
Amreen Mughal et al.
Alzheimer's disease (AD) is a leading cause of dementia and a substantial healthcare burden. Despite this, few treatment options are available for controlling AD symptoms. Notably, neuronal activity-dependent increases in cortical cerebral ...
Robert Tarran,R Graham Barr,Neal L Benowitz et al.
Robert Tarran et al.
E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids, comprised of propylene glycol and vegetable glycerin, typically with nicotine, fl...
Heat Treatment Improves Hepatic Mitochondrial Respiratory Efficiency via Mitochondrial Remodeling [0.03%]
热处理通过线粒体重塑提高肝脏线粒体呼吸效率
Alex T Von Schulze,Fengyan Deng,Kelly N Z Fuller et al.
Alex T Von Schulze et al.
Nonacholic fatty liver disease, or hepatic steatosis, is the most common liver disorder affecting the western world and currently has no pharmacologic cure. Thus, many investigations have focused on alternative strategies to treat or preven...