Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries [0.03%]
二手烟暴露影响肠系膜动脉的离子通道功能和收缩性
Thanhmai Le,Miguel Martín-Aragón Baudel,Arsalan Syed et al.
Thanhmai Le et al.
Cigarette smoke, including secondhand smoke (SHS), has significant detrimental vascular effects, but its effects on myogenic tone of small resistance arteries and the underlying mechanisms are understudied. Although it is apparent that SHS ...
The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree [0.03%]
一个大家系中葡萄糖-半乳糖吸收不良的分子基础
M Pilar Lostao,Donald D Loo,Olle Hernell et al.
M Pilar Lostao et al.
Glucose-galactose malabsorption (GGM) is due to mutations in the gene coding for the intestinal sodium glucose cotransporter SGLT1 (SLC5A1). Here we identify the rare variant Gln457Arg (Q457R) in a large pedigree of patients in the Västerb...
AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels [0.03%]
AKAP79通过组织环核苷酸调节模体调控Orai1介导的钙离子通道的功能
Pulak Kar,Pradeep Barak,Anna Zerio et al.
Pulak Kar et al.
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels. Ca2+ nanodomains near store-operated Or...
Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis [0.03%]
基质结合的生长因子在软骨压缩时释放，此过程依赖于硫酸盐填充 aggrecan 且在骨关节炎中丧失
Stuart J Keppie,Jessica C Mansfield,Xiaodi Tang et al.
Stuart J Keppie et al.
Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we ...
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required [0.03%]
脂肪组织炎症与肥胖诱导的胰岛素抵抗直接相关，而肠道菌群失调和线粒体功能障碍并非必要条件
Heather L Petrick,Kevin P Foley,Soumaya Zlitni et al.
Heather L Petrick et al.
Obesity is associated with adipose tissue hypertrophy, systemic inflammation, mitochondrial dysfunction, and intestinal dysbiosis. Rodent models of high-fat diet (HFD)-feeding or genetic deletion of multifunctional proteins involved in immu...
The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability [0.03%]
窦房结微血管的区域分布与心肌细胞激动性相匹配
Nathan Grainger,Laura Guarina,Robert H Cudmore et al.
Nathan Grainger et al.
The cardiac cycle starts when an action potential is produced by pacemaking cells in the sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million times in mice per day, imposing a monumental metabolic dema...
The Mechanisms of Cellular Plasticity in Collecting Duct Cells: Intermediate Cell Type and Notch-mediated Transdifferentiation [0.03%]
集合管细胞的细胞可塑性机制：中间细胞类型和Notch介导的转分化
Christine A Klemens,Alexander Staruschenko,Oleg Palygin
Christine A Klemens
Capillary Inward-Rectifying K+ Crippled in a Mouse Model of Alzheimer's Disease: Phosphatidylinositol 4,5-Bisphosphate to the Rescue! [0.03%]
阿尔茨海默病小鼠模型中毛细血管钾离子整流功能受损：磷脂酰肌醇(4，5)双磷酸来拯救！
William F Jackson
William F Jackson
Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency [0.03%]
NOX1抑制作用可缓解弹性蛋白缺乏所致血压升高现象
Angela Troia,Russell H Knutsen,Carmen M Halabi et al.
Angela Troia et al.
Elastin (ELN) insufficiency leads to the cardiovascular hallmarks of the contiguous gene deletion disorder, Williams-Beuren syndrome, including hypertension and vascular stiffness. Previous studies showed that Williams-Beuren syndrome delet...
Daniel Bakowski,Andrew J Wood,Anant B Parekh
Daniel Bakowski