David M Pollock
David M Pollock
Sickle Cell Disease and Oxidative Stress: Implications for a Role of Diminished Endothelial SOD2 in Pulmonary Complications [0.03%]
镰形红细胞疾病与氧化应激：内皮超氧化物歧化酶2降低在肺部并发症中作用的启示
Nicola Conran,Fernando F Costa
Nicola Conran
Effects of Pro-Inflammatory Cytokines on the Pancreatic Islet Transcriptome: A View at Both Temporal and Single-Cell Resolution [0.03%]
促炎症细胞因子对胰岛转录组的时空影响：从时间和单细胞分辨率的角度分析
Vaibhav Sidarala,Scott A Soleimanpour
Vaibhav Sidarala
Weak Cation Selectivity in HCN Channels Results From K+-Mediated Release of Na+ From Selectivity Filter Binding Sites [0.03%]
K+介导的选择性过滤器结合位点Na+的释放导致HCN通道弱阳离子选择性
Daniel Bauer,Jan Wissmann,Anna Moroni et al.
Daniel Bauer et al.
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate the pacemaker current which plays an important role in the timing of various biological processes like the heart beat. We used umbrella sampling to explore the pote...
Ole H Petersen,Alexei Verkhratsky
Ole H Petersen
Mobile Anchors [0.03%]
移动锚点
Antonio Zaza
Antonio Zaza
Cellular Bioenergetics: Experimental Evidence for Alcohol-induced Adaptations [0.03%]
细胞生物能量学：酒精引起适应的实验证据
Liz Simon,Patricia E Molina
Liz Simon
At-risk alcohol use is associated with multisystemic effects and end-organ injury, and significantly contributes to global health burden. Several alcohol-mediated mechanisms have been identified, with bioenergetic maladaptation gaining cred...
Acidic Cannabinoids Suppress Proinflammatory Cytokine Release by Blocking Store-operated Calcium Entry [0.03%]
单通道阻断剂丁酸氢化可的松类似物通过抑制钙离子进入减少炎症细胞因子释放作用探究
Malika Faouzi,Clay Wakano,Mahealani K Monteilh-Zoller et al.
Malika Faouzi et al.
Cannabis sativa has long been known to affect numerous biological activities. Although plant extracts, purified cannabinoids, or synthetic cannabinoid analogs have shown therapeutic potential in pain, inflammation, seizure disorders, appeti...
Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function [0.03%]
硫氧还蛋白还原酶的缺失破坏了氧化还原稳态并损害β细胞功能
Jennifer S Stancill,Polly A Hansen,Angela J Mathison et al.
Jennifer S Stancill et al.
Reactive oxygen species (ROS) have been implicated as mediators of pancreatic β-cell damage. While β-cells are thought to be vulnerable to oxidative damage, we have shown, using inhibitors and acute depletion, that thioredoxin reductase, ...