Sonia Sebastian,Lee S Weinstein,Andreas Ludwig et al.
Sonia Sebastian et al.
We aimed to determine the pathophysiological impact of heart rate (HR) slowing on cardiac function. We have recently developed a murine model in which it is possible to conditionally delete the stimulatory heterotrimeric G-protein (Gαs) in...
The Song of the Earth [0.03%]
大地之歌
Ole H Petersen
Ole H Petersen
It is Good to Recycle: Bringing Megalin Back to the Membrane to Stop Proteinuria [0.03%]
回收利用好处多：让megalin回归膜以阻止蛋白尿
Andrew M Hall,Imene Sakhi
Andrew M Hall
The Need for Consistency with Physical Laws and Logic in Choosing Between Competing Molecular Mechanisms in Biological Processes: A Case Study in Modeling ATP Synthesis [0.03%]
在选择生物过程中的竞争分子机制时，需要与物理定律和逻辑保持一致：以ATP合成建模为例
Sunil Nath
Sunil Nath
Traditionally, proposed molecular mechanisms of fundamental biological processes have been tested against experiment. However, owing to a plethora of reasons-difficulty in designing, carrying out, and interpreting key experiments, use of di...
M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors [0.03%]
β-肾上腺素受体活化抑制气道平滑肌中依赖于M2胆碱能受体的收缩反应
Tuleen Alkawadri,Pei Yee Wong,Zhihui Fong et al.
Tuleen Alkawadri et al.
Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylchol...
ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell [0.03%]
胰岛β细胞中ER氧化还原稳态调控胰岛素原转运及胰岛素颗粒形成
Kristen E Rohli,Cierra K Boyer,Shelby C Bearrows et al.
Kristen E Rohli et al.
Defects in the pancreatic β-cell's secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms unde...
An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule [0.03%]
一种可塑的生理模型：细毛肾细胞和小鼠近端肾小管中内吞Megalin转运模型
Katherine E Shipman,Kimberly R Long,Isabella A Cowan et al.
Katherine E Shipman et al.
The cells that comprise the proximal tubule (PT) are specialized for high-capacity apical endocytosis necessary to maintain a protein-free urine. Filtered proteins are reclaimed via receptor-mediated endocytosis facilitated by the multiliga...
Eric Accili
Eric Accili
Ever since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassium current in the heart called I K2. How...
Propagation of Pacemaker Activity and Peristaltic Contractions in the Mouse Renal Pelvis Rely on Ca2+-activated Cl- Channels and T-Type Ca2+ Channels [0.03%]
钙离子激活的氯离子通道和T型钙离子通道依赖途径在小鼠肾盂起搏活动及蠕动收缩中的作用研究
Nathan Grainger,Cameron C Shonnard,Sage K Quiggle et al.
Nathan Grainger et al.
The process of urine removal from the kidney occurs via the renal pelvis (RP). The RP demarcates the beginning of the upper urinary tract and is endowed with smooth muscle cells. Along the RP, organized contraction of smooth muscle cells ge...