Agnieszka K Borowik,Arik Davidyan,Frederick F Peelor rd et al.
Agnieszka K Borowik et al.
The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie, myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D2O) labeling studies showed DNA synthesis in skeletal muscl...
Capsaicin-Induced Endocytosis of Endogenous Presynaptic CaV2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function [0.03%]
辣椒素诱导的DRG-脊髓共培养物中内源性突触前CaV2.2的胞吞作用抑制了突触前功能
Krishma H Ramgoolam,Annette C Dolphin
Krishma H Ramgoolam
The N-type calcium channel, CaV2.2 is key to neurotransmission from the primary afferent terminals of dorsal root ganglion (DRG) neurons to their postsynaptic targets in the spinal cord. In this study, we have utilized CaV2.2_HA knock-in mi...
Sonia Sebastian,Lee S Weinstein,Andreas Ludwig et al.
Sonia Sebastian et al.
We aimed to determine the pathophysiological impact of heart rate (HR) slowing on cardiac function. We have recently developed a murine model in which it is possible to conditionally delete the stimulatory heterotrimeric G-protein (Gαs) in...
The Song of the Earth [0.03%]
大地之歌
Ole H Petersen
Ole H Petersen
It is Good to Recycle: Bringing Megalin Back to the Membrane to Stop Proteinuria [0.03%]
回收利用好处多：让megalin回归膜以阻止蛋白尿
Andrew M Hall,Imene Sakhi
Andrew M Hall
The Need for Consistency with Physical Laws and Logic in Choosing Between Competing Molecular Mechanisms in Biological Processes: A Case Study in Modeling ATP Synthesis [0.03%]
在选择生物过程中的竞争分子机制时，需要与物理定律和逻辑保持一致：以ATP合成建模为例
Sunil Nath
Sunil Nath
Traditionally, proposed molecular mechanisms of fundamental biological processes have been tested against experiment. However, owing to a plethora of reasons-difficulty in designing, carrying out, and interpreting key experiments, use of di...
M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors [0.03%]
β-肾上腺素受体活化抑制气道平滑肌中依赖于M2胆碱能受体的收缩反应
Tuleen Alkawadri,Pei Yee Wong,Zhihui Fong et al.
Tuleen Alkawadri et al.
Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylchol...
ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell [0.03%]
胰岛β细胞中ER氧化还原稳态调控胰岛素原转运及胰岛素颗粒形成
Kristen E Rohli,Cierra K Boyer,Shelby C Bearrows et al.
Kristen E Rohli et al.
Defects in the pancreatic β-cell's secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms unde...
An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule [0.03%]
一种可塑的生理模型：细毛肾细胞和小鼠近端肾小管中内吞Megalin转运模型
Katherine E Shipman,Kimberly R Long,Isabella A Cowan et al.
Katherine E Shipman et al.
The cells that comprise the proximal tubule (PT) are specialized for high-capacity apical endocytosis necessary to maintain a protein-free urine. Filtered proteins are reclaimed via receptor-mediated endocytosis facilitated by the multiliga...