Ole H Petersen
Ole H Petersen
Osama F Harraz
Osama F Harraz
Mitochondrial ATP Production is Required for Endothelial Cell Control of Vascular Tone [0.03%]
线粒体ATP产生是内皮细胞控制血管张力的必要条件
Calum Wilson,Matthew D Lee,Charlotte Buckley et al.
Calum Wilson et al.
Arteries and veins are lined by nonproliferating endothelial cells that play a critical role in regulating blood flow. Endothelial cells also regulate tissue perfusion, metabolite exchange, and thrombosis. It is thought that endothelial cel...
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior [0.03%]
肾上腺特异性敲除节律蛋白BMAL1基因小鼠血压节律和进食行为的时相发生改变
Hannah M Costello,G Ryan Crislip,Kit-Yan Cheng et al.
Hannah M Costello et al.
Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global Bmal1 knockout (KO) mice exhibit ∼10 mmHg reduction in ...
The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior [0.03%]
肠菌微生物群内源大麻素系统轴：调控代谢、炎症和行为的新途径
Cristoforo Silvestri,Vincenzo Di Marzo
Cristoforo Silvestri
Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders [0.03%]
将转基因生产与ω-3 PUFA补充进行比较，揭示了预防代谢和肝病的保护机制的不同但又相互重叠的地方
Noëmie Daniel,Mélanie Le Barz,Patricia L Mitchell et al.
Noëmie Daniel et al.
We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 to ω-3 PUFA, and wild-type littermates were fed a high-fat d...
Birgit Hoeger,Susanna Zierler
Birgit Hoeger
Anant B Parekh,Lord Bhikhu C Parekh
Anant B Parekh
Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity [0.03%]
高通量成像和多参数代谢分析的结合揭示了替诺福韦毒性的一种线粒体机制
Adam Pearson,Dominik Haenni,Jamal Bouitbir et al.
Adam Pearson et al.
Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting the need for better experimental models and methodological approaches. Most nephrotoxins da...
Espen E Spangenburg
Espen E Spangenburg