David C Poole,Timothy I Musch
David C Poole
When exercising humans increase their oxygen uptake (V̇O2) 20-fold above rest the numbers are staggering: Each minute the O2 transport system - lungs, cardiovascular, active muscles - transports and utilizes 161 sextillion (10 21) O2 molec...
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle [0.03%]
小鼠趾屈肌骨骼肌低氧耐受性表型的研究
Adam J Amorese,Everett C Minchew,Michael D Tarpey et al.
Adam J Amorese et al.
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in mu...
Differential Control of Small-conductance Calcium-activated Potassium Channel Diffusion by Actin in Different Neuronal Subcompartments [0.03%]
actin对不同神经子隔室中较小电导钙激活的钾通道扩散的不同控制作用
Shiju Gu,Anastasios V Tzingounis,George Lykotrafitis
Shiju Gu
Small-conductance calcium-activated potassium (SK) channels show a ubiquitous distribution on neurons, in both somatodendritic and axonal regions. SK channels are associated with neuronal activity regulating action potential frequency, dend...
Do Endogenously Produced and Dietary ω-3 Fatty Acids Act Differently? [0.03%]
内源性产生的和膳食ω-3脂肪酸的作用不同吗？
Philip C Calder
Philip C Calder
Precision Medicine in Pancreatitis: The Future of Acute Pancreatitis Care [0.03%]
精准医学在胰腺炎中的应用：急性胰腺炎治疗的未来方向
Andras Garami,Peter Hegyi
Andras Garami
Acute pancreatitis (AP) continues to present a substantial burden to patients and healthcare personnel. Despite its occasionally severe progression and high mortality rate, there is no specific therapy that could be routinely applied in pat...
Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels [0.03%]
氧化驱动的GIRK2通道PIP2依赖性调控的反转效应
Sun-Joo Lee,Shoji Maeda,Jian Gao et al.
Sun-Joo Lee et al.
Physiological activity of G protein gated inward rectifier K+ (GIRK, Kir3) channel, dynamically regulated by three key ligands, phosphoinositol-4,5-bisphosphate (PIP2), Gβγ, and Na+, underlies cellular electrical response to multiple horm...
Plagiarism Reimagined [0.03%]
被重构的剽窃行为
R A North
R A North
Refining the Treatment of Pancreatic Cancer From Big Data to Improved Individual Survival [0.03%]
从大数据到改善个体生存：胰腺癌治疗的改进方向
Peter Bailey,Xu Zhou,Jingyu An et al.
Peter Bailey et al.
Pancreatic cancer is one of the most lethal cancers worldwide, most notably in Europe and North America. Great strides have been made in combining the most effective conventional therapies to improve survival at least in the short and mediu...
Defining the Specialized Functions of cAMP Signals in an Organelle Formerly Deemed to Have No Function: The Primary Cilium [0.03%]
厘清环磷酸腺苷信号在一向被认为无功能的细胞器中的专业功能——原初纤毛
Aldebaran M Hofer
Aldebaran M Hofer
BMAL1 in the Adrenal Gland: It's About Time-A Perspective on "Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior" [0.03%]
关于“肾上腺节律钟蛋白BMAL1的特异性敲除改变了血压节律和进食行为的时间”的观点-肾上腺中的BMAL1：一切尽在时间之中
Brittni N Moore,Jennifer L Pluznick
Brittni N Moore