Skeletal Muscle Consequences of Phosphatidylethanolamine Synthesis Deficiency [0.03%]
磷脂酰乙醇胺合成缺陷的骨骼肌后果
Sophie Grapentine,Rathnesh K Singh,Marica Bakovic
Sophie Grapentine
The maintenance of phospholipid homeostasis is increasingly being implicated in metabolic health. Phosphatidylethanolamine (PE) is the most abundant phospholipid on the inner leaflet of cellular membranes, and we have previously shown that ...
Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels [0.03%]
ML252抑制Kv7电压门控钾通道的作用位点及其作用机制研究
Richard Kanyo,Shawn M Lamothe,Arturo Urrutia et al.
Richard Kanyo et al.
Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications. Drug discovery efforts have identified small molecules that modulate channel ...
Anna Boccaccio,Rocio K Finol-Urdaneta
Anna Boccaccio
Post-injury Inhibition of Endothelin-1 Dependent Renal Vasoregulation Mitigates Rhabdomyolysis-Induced Acute Kidney Injury [0.03%]
损伤后抑制内皮素-1依赖性肾血管调节减轻横纹肌溶解引起的急性肾脏损伤
Jeremiah M Afolabi,Praghalathan Kanthakumar,Jada D Williams et al.
Jeremiah M Afolabi et al.
In patients with rhabdomyolysis, the overwhelming release of myoglobin into the circulation is the primary cause of kidney injury. Myoglobin causes direct kidney injury as well as severe renal vasoconstriction. An increase in renal vascular...
Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function [0.03%]
KATP通道功能增强型Cantú综合征小鼠模型中的淋巴管收缩功能障碍
Michael J Davis,Jorge A Castorena-Gonzalez,Hae Jin Kim et al.
Michael J Davis et al.
Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of KATP channels. KATP overactivity results in a chronic reduction in arterial tone and hypotension, leading t...
Renal Dysfunction due to Tenofovir-Diphosphate Inhibition of Mitochondrial Complex V (ATP Synthase) [0.03%]
替诺福韦抑制线粒体复合物V(腺苷三磷酸合成酶)所致肾功能损害
Nicolas Sluis-Cremer
Nicolas Sluis-Cremer
David C Poole,Timothy I Musch
David C Poole
When exercising humans increase their oxygen uptake (V̇O2) 20-fold above rest the numbers are staggering: Each minute the O2 transport system - lungs, cardiovascular, active muscles - transports and utilizes 161 sextillion (10 21) O2 molec...
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle [0.03%]
小鼠趾屈肌骨骼肌低氧耐受性表型的研究
Adam J Amorese,Everett C Minchew,Michael D Tarpey et al.
Adam J Amorese et al.
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in mu...