Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice [0.03%]
基于尿液检测C57BL/6小鼠先天性门体分流症的方法
Beng San Yeoh,Rachel M Golonka,Piu Saha et al.
Beng San Yeoh et al.
Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore...
APOE4, Age, and Sex Regulate Respiratory Plasticity Elicited by Acute Intermittent Hypercapnic-Hypoxia [0.03%]
APOE4、年龄和性别调节急性间歇性高碳酸血症-低氧引起的呼吸可塑性
Jayakrishnan Nair,Joseph F Welch,Alexandria B Marciante et al.
Jayakrishnan Nair et al.
Rationale: Acute intermittent hypoxia (AIH) shows promise for enhancing motor recovery in chronic spinal cord injuries and neurodegenerative diseases. However, human trials of AIH have reported significant variability in ...
Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination [0.03%]
RhoBTB1的结构与功能及其在底物特异性和CUL3泛素化中的作用
Gaurav Kumar,Shi Fang,Daria Golosova et al.
Gaurav Kumar et al.
We identified Rho-related BTB domain containing 1 (RhoBTB1) as a key regulator of phosphodiesterase 5 (PDE5) activity, and through PDE5, a regulator of vascular tone. We identified the binding interface for PDE5 on RhoBTB1 by truncating ful...
Computational Modeling of Substrate-Dependent Mitochondrial Respiration and Bioenergetics in the Heart and Kidney Cortex and Outer Medulla [0.03%]
基于底物的依赖性线粒体呼吸作用和心脏以及肾脏皮质和外髓的生物能量计算模型
Shima Sadri,Xiao Zhang,Said H Audi et al.
Shima Sadri et al.
Integrated computational modeling provides a mechanistic and quantitative framework to characterize alterations in mitochondrial respiration and bioenergetics in response to different metabolic substrates in-silico. These alterations play c...
Locomotion Induces Fundamentally Different Patterns of Ca2+ Signaling in Astrocytes and Neurons [0.03%]
运动诱导星形胶质细胞和神经元中的钙信号产生不同的基本模式
Hajime Hirase,Maiken Nedergaard
Hajime Hirase
Ole H Petersen
Ole H Petersen
Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice [0.03%]
APP/PS1老年小鼠中内源淀粉样蛋白形成的钙离子通道
Shuangtao Li,Xiaoyu Ji,Ming Gao et al.
Shuangtao Li et al.
Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of beta-amyloid peptides (Aβ). However, whether Aβ itself is a key toxic agent in AD pathogenesis and the precise mechanism of Aβ-elicited neur...
The Molecular Circadian Clock of Phox2b-expressing Cells Drives Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory Response in Mice [0.03%]
小鼠表达Phox2b的细胞的分子生物钟驱动每日低氧但不高碳酸血症通气反应的变化
Aaron A Jones,Gabriella M Marino,Allison R Spears et al.
Aaron A Jones et al.
While the suprachiasmatic nucleus (SCN) controls 24-h rhythms in breathing, including minute ventilation (VE), the mechanisms by which the SCN drives these daily changes are not well understood. Moreover, the extent to which the circadian c...
A Perspective on "Hypoxia Resistance is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle" [0.03%]
对「小鼠趾屈肌骨骼肌低氧耐受性是固有表型」的观点
Camila Padilha,Ashleigh M Philp
Camila Padilha
Dissociation Between Neuronal and Astrocytic Calcium Activity in Response to Locomotion in Mice [0.03%]
小鼠回应运动的神经元和星形胶质细胞钙离子活动分离现象
Anna Fedotova,Alexey Brazhe,Maxim Doronin et al.
Anna Fedotova et al.
Locomotion triggers a coordinated response of both neurons and astrocytes in the brain. Here we performed calcium (Ca2+) imaging of these two cell types in the somatosensory cortex in head-fixed mice moving on the airlifted platform. Ca2+ a...