Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat [0.03%]
大鼠饮食磷浓度变化对肠肾适应性的影响研究
Susana Lucea,Gema Chopo-Escuin,Natalia Guillén et al.
Susana Lucea et al.
We have studied the role of the intestine, kidney, and several hormones when adapting to changes in dietary P concentration. Normal and parathyroidectomized (PTX) rats were fed pH-matched diets containing 0.1%, 0.6%, and 1.2% P concentratio...
Cristina Concetti,Daria Peleg-Raibstein,Denis Burdakov
Cristina Concetti
Modern neuroscience is progressively elucidating that the classic view positing distinct brain regions responsible for survival, emotion, and cognitive functions is outdated. The hypothalamus demonstrates the interdependence of these roles,...
The Interplay Between Splicing of Two Exon Combinations Differentially Affects Membrane Targeting and Function of Human CaV2.2 [0.03%]
两种外显子组合剪接的相互作用通过不同的方式影响人类CaV2.2的膜定位和功能
Shehrazade Dahimene,Karen M Page,Manuela Nieto-Rostro et al.
Shehrazade Dahimene et al.
N-type calcium channels (CaV2.2) are predominantly localized in presynaptic terminals, and are particularly important for pain transmission in the spinal cord. Furthermore, they have multiple isoforms, conferred by alternatively spliced or ...
Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice [0.03%]
协同调节核DNA甲基化，mRNA和miRNA水平与雌性小鼠快速协同消融诱导的骨骼肌肥大代谢反应有关
Ahmed Ismaeel,Nicholas T Thomas,Mariah McCashland et al.
Ahmed Ismaeel et al.
The central dogma of molecular biology dictates the general flow of molecular information from DNA that leads to a functional cellular outcome. In skeletal muscle fibers, the extent to which global myonuclear transcriptional alterations, ac...
Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury [0.03%]
中性粒细胞特异性ORAI1钙通道抑制可减少急性胰腺炎相关的急性肺损伤
Mengya Niu,Xiuli Zhang,Zengkai Wu et al.
Mengya Niu et al.
Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated systemic inflammatory responses mediated by neutrophils. Store-operated Ca2+ entry (SOCE) through ORAI1 channels in pancreatic acinar cells trigg...
Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome [0.03%]
唐氏综合征动物模型(Ts65Dn)小鼠的呼吸和携氧能力的研究
Lara R DeRuisseau,Candace N Receno,Caitlin Cunningham et al.
Lara R DeRuisseau et al.
Individuals with Down syndrome (Ds) are at increased risk of respiratory infection, aspiration pneumonia, and apnea. The Ts65Dn mouse is a commonly used model of Ds, but there have been no formal investigations of awake breathing and respir...
Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue [0.03%]
CKMT1在白色/棕色脂肪组织线粒体生物能中可有可无
Valerie Politis-Barber,Heather L Petrick,Arthe Raajendiran et al.
Valerie Politis-Barber et al.
Within brown adipose tissue (BAT), the brain isoform of creatine kinase (CKB) has been proposed to regulate the regeneration of ADP and phosphocreatine in a futile creatine cycle (FCC) that stimulates energy expenditure. However, the presen...
Breast Milk Epidermal Growth Factor Confers Paracellular Calcium Absorption in the Infant Small Intestine [0.03%]
母乳表皮生长因子促进婴儿小肠的跨细胞钙吸收
Andreanna Burman,Izumi Kaji
Andreanna Burman
Pol Bech,Sylvain Crochet,Robin Dard et al.
Pol Bech et al.
We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circ...
Overcoming Confounding to Characterize the Effects of Calcium Channel Blockers [0.03%]
克服混杂因素以表征钙通道阻滞剂的效果
Sudarshan Rajagopal,Paul B Rosenberg
Sudarshan Rajagopal