Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury [0.03%]
Megalin敲除降低SGLT2表达并导致西方饮食诱导的肾脏损伤敏感性增加
Elynna B Youm,Katherine E Shipman,Wafaa N Albalawy et al.
Elynna B Youm et al.
Megalin (Lrp2) is a multiligand receptor that drives endocytic flux in the kidney proximal tubule (PT) and is necessary for the recovery of albumin and other filtered proteins that escape the glomerular filtration barrier. Studies in our la...
Electrophysiology of human iPSC-derived vascular smooth muscle cells and cell autonomous consequences of Cantu Syndrome mutations [0.03%]
人诱导性多能干细胞来源的血管平滑肌细胞电生理及其坎图综合征突变的自主细胞后果
Alex Hanson,Conor McClenaghan,Kuo-Chan Weng et al.
Alex Hanson et al.
Objective: Cantu Syndrome (CS), a multisystem disease with a complex cardiovascular phenotype, is caused by GoF variants in the Kir6.1/SUR2 subunits of ATP-sensitive potassium (KATP) channels, and is characterized by low ...
Sex-Specific Effects of Cholesteryl Ester Transfer Protein (CETP) on the Perivascular Adipose Tissue [0.03%]
性别特异性胆固醇酯转移蛋白(CETP)对血管周围脂肪组织的影响
C M Lazaro,I N Freitas,V S Nunes et al.
C M Lazaro et al.
Cholesteryl ester transfer protein (CETP) increases the atherosclerosis risk by lowering HDL-cholesterol levels. It also exhibits tissue-specific effects independent of HDL. However, sexual dimorphism of CETP effects remains largely unexplo...
Rebekah J Nicholson,Nirupama Ramkumar,Aylin R Rodan
Rebekah J Nicholson
Physiology Brings Relevance to Biological Research: A Vision for Function [0.03%]
生理学使生物研究更具现实意义：一种功能视角的愿景
David M Pollock
David M Pollock
Exit, O Sodium! [0.03%]
走吧，钠！
Sergej Pirkmajer,Alexander V Chibalin
Sergej Pirkmajer
Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity [0.03%]
人骨骼肌表达脑源性神经营养因子而非成熟型脑源性神经营养因子：对运动诱导神经可塑性的启示
Sebastian Edman,Oscar Horwath,Thibaux Van der Stede et al.
Sebastian Edman et al.
Exercise promotes brain plasticity partly by stimulating increases in mature brain-derived neurotrophic factor (mBDNF), but the role of the pro-BDNF isoform in the regulation of BDNF metabolism in humans is unknown. We quantified the expres...
Systems Approaches to Cell Culture-Derived Extracellular Vesicles for Acute Kidney Injury Therapy: Prospects and Challenges [0.03%]
用于急性肾损伤治疗的细胞培养来源的外泌体系统方法：前景与挑战
David J Lundy,Barbara Szomolay,Chia-Te Liao
David J Lundy
Acute kidney injury (AKI) is a heterogeneous syndrome, comprising diverse etiologies of kidney insults that result in high mortality and morbidity if not well managed. Although great efforts have been made to investigate underlying pathogen...
The Warburg Effect Reinterpreted 100 yr on: A First-Principles Stoichiometric Analysis and Interpretation from the Perspective of ATP Metabolism in Cancer Cells [0.03%]
沃伯格效应重释一百年后的今天：从癌症细胞ATP代谢角度的第一性原理计量分析和解读
Sunil Nath,Rudi Balling
Sunil Nath
The Warburg Effect is a longstanding enigma in cancer biology. Despite the passage of 100 yr since its discovery, and the accumulation of a vast body of research on the subject, no convincing biochemical explanation has been given for the o...