Regulation of antibody responses against self and foreign antigens by Tfr cells: implications for vaccine development [0.03%]
Tfr细胞对自身抗原和外源性抗原抗体反应的调节作用及其在疫苗开发中的意义
Afonso P Basto,Luis Graca
Afonso P Basto
The production of antibodies can constitute a powerful protective mechanism against infection, but antibodies can also participate in autoimmunity and allergic responses. Recent advances in the understanding of the regulation of germinal ce...
Chloe Rees-Spear,Laura E McCoy
Chloe Rees-Spear
Over the last few decades, changing population demographics have shown that there are a growing number of individuals living past the age of 60. With this expanding older population comes an increase in individuals that are more susceptible...
TB or not to be: what specificities and impact do antibodies have during tuberculosis? [0.03%]
结核病防治的免疫学：抗体有哪些特定作用及其影响？
Clemens Hermann,Carolyn G King
Clemens Hermann
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis (Mtb), is a major cause of global morbidity and mortality. The primary barrier to the development of an effective tuberculosis vaccine is our failure to fully understa...
Isabella Cinti,Alice E Denton
Isabella Cinti
The generation of high-affinity long-lived antibody responses is dependent on the differentiation of plasma cells and memory B cells, which are themselves the product of the germinal centre (GC) response. The GC forms in secondary lymphoid ...
Daniel M Altmann
Daniel M Altmann
Endogenous antibody responses in REGN-COV2-treated SARS-CoV-2-infected individuals [0.03%]
REGN-COV2治疗的SARS-CoV-2感染者的内源性抗体反应
Ashwini Kurshan,Luke B Snell,Lucie Prior et al.
Ashwini Kurshan et al.
Neutralizing monoclonal antibodies (mAbs) targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein have been developed for the treatment of COVID-19. Whilst antibody therapy has been shown to reduce the risk...
Polymer formulated self-amplifying RNA vaccine is partially protective against influenza virus infection in ferrets [0.03%]
聚合物配制的自我放大RNA疫苗可保护雪貂免受流感病毒感染
P F McKay,J Zhou,R Frise et al.
P F McKay et al.
COVID-19 has demonstrated the power of RNA vaccines as part of a pandemic response toolkit. Another virus with pandemic potential is influenza. Further development of RNA vaccines in advance of a future influenza pandemic will save time and...
The past, current and future epidemiological dynamic of SARS-CoV-2 [0.03%]
SARS-CoV-2的过去、现在和未来的流行病学动态
François Balloux,Cedric Tan,Leo Swadling et al.
François Balloux et al.
SARS-CoV-2, the agent of the COVID-19 pandemic, emerged in late 2019 in China, and rapidly spread throughout the world to reach all continents. As the virus expanded in its novel human host, viral lineages diversified through the accumulati...
Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology [0.03%]
中性粒细胞增多、淋巴细胞减少和髓系细胞功能障碍：定量定义COVID-19病理的固有性和适应性免疫细胞的变化
Amy S Codd,Stephanie J Hanna,Ewoud B Compeer et al.
Amy S Codd et al.
Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndro...
Overview of approved and upcoming vaccines for SARS-CoV-2: a living review [0.03%]
SARS-CoV-2获批及即将上市疫苗综述：一项实时更新的综述
Jennifer Alderson,Vicky Batchelor,Miriam O&#x;Hanlon et al.
Jennifer Alderson et al.
The rapid design and implementation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is testament to a successfully coordinated global research effort. While employing a variety of different technologies, some of whi...